Acanthosis nigricanshttps://en.wikipedia.org/wiki/Acanthosis_nigricans
Acanthosis nigricans is 'n mediese teken wat gekenmerk word deur bruin-tot-swart, swak gedefinieerde, fluweelagtige hiperpigmentasie van die vel. Dit word gewoonlik in liggaamsvoue aangetref, soos die posterior en laterale voue van die nek, die oksels, lies, naeltjie, voorkop en ander areas. Dit word geassosieer met endokriene disfunksie, veral insulienweerstandigheid en hiperinsulienemie, soos gesien in diabetes mellitus.

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Dit kom tipies voor by individue jonger as 40, kan geneties geërf word en word geassosieer met vetsug of endokrinopatieë, soos hipotireose, akromegalie, polisistiese ovariumsiekte, insulienweerstandige diabetes of Cushing se siekte.

Behandeling ― OTC-dwelms
#40% urea cream
☆ In die 2022 Stiftung Warentest-resultate van Duitsland was verbruikerstevredenheid met ModelDerm net effens laer as met betaalde telemedisyne-konsultasies.
  • Dit is algemeen by vetsugtige mense.
  • Swart pigmentasie en plooie in albei oksels suggereer Acanthosis nigricans.
References Acanthosis Nigricans 28613711 
NIH
Acanthosis nigricans is 'n kutane manifestasie van 'n onderliggende toestand. Dit verskyn dikwels in velvoue soos die nek, oksels en lies, en lyk soos fluweelagtige donker kolle met onduidelike rande. Hierdie toestand word gewoonlik aan diabetes en insulienweerstandigheid gekoppel, maar in seldsame gevalle kan dit op kanker in die liggaam dui. Dit kan ook verskyn as gevolg van hormoonprobleme of as gevolg van die neem van spesifieke medikasie soos steroïede en geboortebeperkingspille.
Acanthosis nigricans is a cutaneous manifestation of an underlying condition. It usually develops in skin folds, such as the back of the neck, axilla, and groin, where it presents as velvety hyper-pigmented patches with poorly defined borders. Acanthosis nigricans is most commonly associated with diabetes and insulin resistance, but rarely it can be a sign of internal malignancy. It can also occur with hormone disorders or with the use of certain medications like systemic glucocorticoids and oral contraceptives.
 Current treatment options for acanthosis nigricans 30122971 
NIH
Acanthosis nigricans (AN) is 'n algemene veltoestand wat verband hou met verskeie gesondheidskwessies soos insulienweerstandigheid, diabetes, vetsug, sekere kankers, hormonale probleme en reaksies op medikasie. Die behandeling van AN fokus daarop om die onderliggende gesondheidsprobleme aan te spreek. Aanvanklik kyk dokters na tekens van insulienweerstandsindroom, wat vetsug, hoë cholesterol, hoë bloeddruk en tipe 2-diabetes insluit. Dokters skryf dikwels topical retinoids voor as die eerste behandelingskeuse, wat kan help met velverdikking. Hulle kan egter nie die vel verdonkering ten volle aanspreek nie. Ander behandelingsopsies (salicylic acid, podophyllin, urea, calcipotriol) moet ook gereeld toegedien word.
Acanthosis nigricans (AN) is a common dermatologic manifestation of systemic disease that is associated with insulin resistance, diabetes mellitus, obesity, internal malignancy, endocrine disorders, and drug reactions. Treatment of AN primarily focuses on resolution of the underlying disease processes causing the velvety, hyperpigmented, hyperkeratotic plaques found on the skin. Initial considerations for the AN workup include evaluating patients for insulin resistance syndrome characterized by obesity, dyslipidemia, hypertension, and diabetes mellitus type II. For cosmetic treatment, topical retinoids are considered the first-line therapy for insulin-resistant AN by modifying keratinization rate. However, topical tretinoin requires application for long durations and improves hyperkeratosis, but not hyperpigmentation. Topical salicylic acid, podophyllin, urea, and calcipotriol also require frequent application, while TCA peels may provide a faster and less time-intense burden.