Amyloidosis - Amiloïdose
☆ In die 2022 Stiftung Warentest-resultate van Duitsland was verbruikerstevredenheid met ModelDerm net effens laer as met betaalde telemedisyne-konsultasies.
Klassieke gelaatstrekke van Amiloïdose (Amyloidosis)
References
'n 26-jarige vrou het na ons kliniek gekom en kla oor 'n jeukerige uitslag op haar bene wat sy al 10 jaar gehad het. Ten spyte van die gebruik van steroïedroom en tazaroteenroom, het die uitslag nie beter geword nie. Sy het geen relevante familiegeskiedenis gehad nie. Toe ons haar ondersoek het, het ons verhewe, growwe kolle aan die voorkant van haar bene gevind, wat ooreenstem met 'n siekte genaamd lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
Lichen Amyloidosis is 'n seldsame veltoestand wat verband hou met aanhoudende jeuk van onbekende oorsaak. Dit verskyn tipies as trosse verhewe, verkleurde kolle op die vel se buitenste oppervlaktes. Lichen Amyloidosis kom gewoonlik voor by mense tussen die ouderdomme van 50 en 60 en daar is ongelukkig geen genesing daarvoor nie. Behandelings wat nou beskikbaar is, werk gewoonlik nie goed nie.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen amyloidosis is 'n langdurige jeukerige veltoestand. Dit is bekend vir trosse verdikte knoppe wat hoofsaaklik op die rug, skene, dye en arms voorkom. Wanneer dit onder 'n mikroskoop ondersoek word, toon Lichen amyloidosis 'n opbou van amiloïed in die boonste laag vel tesame met verdikking en vergroting van die buitenste vellaag. Alhoewel die presiese oorsaak van Lichen amyloidosis nog nie ten volle verstaan word nie, het vorige studies dit gekoppel aan faktore soos vryf of wrywing op die vel, seldood, virale infeksies, onder andere. Lichen amyloidosis blyk te wees gekoppel aan verskeie ander veltoestande (atopic dermatitis, lichen planus, mycosis fungoides) .
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
○ Diagnose en behandeling
#Electrophoresis of blood or urine
#Skin biopsy