Basal cell carcinoma - Basale Selkarsinoom
☆ In die 2022 Stiftung Warentest-resultate van Duitsland was verbruikerstevredenheid met ModelDerm net effens laer as met betaalde telemedisyne-konsultasies.
Ulcerasie letsels wat die vel van die neus by 'n bejaarde individu aantas, word dikwels as Basale Selkarsinoom (Basal cell carcinoma) gediagnoseer. Die neus is 'n algemene plek van voorkoms van hierdie tipe velkanker.
Basale Selkarsinoom (Basal cell carcinoma) kan met onreëlmatige rande en maagsere voorkom.
Basale Selkarsinoom (Basal cell carcinoma) kan verwar word met wrat.
References
Basal cell carcinoma (BCC) is die mees algemene tipe velkanker. Blootstelling aan sonlig is die hoofoorsaak. Byna alle BCC-gevalle toon ooraktiewe Egel-sein in die molekulêre analise. Verskillende behandelings is beskikbaar en gekies op grond van herhalingsrisiko, belangrikheid van weefselpreservering, pasiëntvoorkeur en omvang van siekte.
Basal cell carcinoma (BCC) is the most common malignancy. Exposure to sunlight is the most important risk factor. Most, if not all, cases of BCC demonstrate overactive Hedgehog signaling. A variety of treatment modalities exist and are selected based on recurrence risk, importance of tissue preservation, patient preference, and extent of disease.
Basal cell carcinoma (BCC) is the most common malignancy. Exposure to sunlight is the most important risk factor. Most, if not all, cases of BCC demonstrate overactive Hedgehog signaling. A variety of treatment modalities exist and are selected based on recurrence risk, importance of tissue preservation, patient preference, and extent of disease.
Basal cell carcinomas is die mees algemene tipe velkanker by volwassenes van 50 jaar en ouer met 'n ligte vel. Hulle getalle neem wêreldwyd toe, hoofsaaklik as gevolg van blootstelling aan sonlig. Sekere genetiese toestande kan mense geneig maak om hierdie kankers op 'n jonger ouderdom te ontwikkel. Basal cell carcinomas wissel in erns, wat wissel van maklik behandelbare oppervlakkige of nodulêre letsels tot meer uitgebreide wat bespreking in gespesialiseerde mediese spanne vereis. Prognose hang af van die waarskynlikheid dat kanker terugkeer of die vermoë daarvan om nabygeleë weefsel te beskadig. Chirurgie is die standaardbehandeling vir die meeste gevalle, wat presiese verwydering en lae kanse op herhaling verseker. Minder indringende metodes kan oppervlakkige letsels effektief behandel.
Basal cell carcinomas are the most frequent skin cancers in the fair-skinned adult population over 50 years of age. Their incidence is increasing throughout the world. Ultraviolet (UV) exposure is the major carcinogenic factor. Some genodermatosis can predispose to formation of basal cell carcinomas at an earlier age. Basal cell carcinomas are heterogeneous, from superficial or nodular lesions of good prognosis to very extensive difficult-to-treat lesions that must be discussed in multidisciplinary committees. The prognosis is linked to the risk of recurrence of basal cell carcinoma or its local destructive capacity. The standard treatment for most basal cell carcinomas is surgery, as it allows excision margin control and shows a low risk of recurrence. Superficial lesions can be treated by non-surgical methods with significant efficacy.
Basal cell carcinomas are the most frequent skin cancers in the fair-skinned adult population over 50 years of age. Their incidence is increasing throughout the world. Ultraviolet (UV) exposure is the major carcinogenic factor. Some genodermatosis can predispose to formation of basal cell carcinomas at an earlier age. Basal cell carcinomas are heterogeneous, from superficial or nodular lesions of good prognosis to very extensive difficult-to-treat lesions that must be discussed in multidisciplinary committees. The prognosis is linked to the risk of recurrence of basal cell carcinoma or its local destructive capacity. The standard treatment for most basal cell carcinomas is surgery, as it allows excision margin control and shows a low risk of recurrence. Superficial lesions can be treated by non-surgical methods with significant efficacy.
Die primêre behandeling vir BCC is chirurgie. Vir hoë-risiko of herhalende BCC, veral in kritieke areas, word mikrografies beheerde chirurgie aanbeveel. Pasiënte met 'n lae-risiko oppervlakkige BCC kan aktuele behandelings of vernietigende metodes oorweeg. Fotodinamiese terapie werk goed vir oppervlakkige en lae-risiko nodulêre BCC's. Vir plaaslik gevorderde of metastatiese BCC word Hedgehog inhibeerders (vismodegib, sonidegib) aanbeveel. As daar siekteprogressie of onverdraagsaamheid teenoor Egel-inhibeerders is, kan immunoterapie met anti-PD1 antibody (cemiplimab) oorweeg word. Radioterapie is 'n goeie opsie vir pasiënte wat nie chirurgie kan ondergaan nie, veral ouer pasiënte. Elektrochemoterapie kan oorweeg word as chirurgie of radioterapie nie 'n opsie is nie.
The primary treatment for BCC is surgery. For high-risk or recurring BCC, especially in critical areas, micrographically controlled surgery is recommended. Patients with low-risk superficial BCC might consider topical treatments or destructive methods. Photodynamic therapy works well for superficial and low-risk nodular BCCs. For locally advanced or metastatic BCC, Hedgehog inhibitors (vismodegib, sonidegib) are recommended. If there's disease progression or intolerance to Hedgehog inhibitors, immunotherapy with anti-PD1 antibody (cemiplimab) can be considered. Radiotherapy is a good option for patients who can't have surgery, especially older patients. Electrochemotherapy could be considered if surgery or radiotherapy isn't an option.
The primary treatment for BCC is surgery. For high-risk or recurring BCC, especially in critical areas, micrographically controlled surgery is recommended. Patients with low-risk superficial BCC might consider topical treatments or destructive methods. Photodynamic therapy works well for superficial and low-risk nodular BCCs. For locally advanced or metastatic BCC, Hedgehog inhibitors (vismodegib, sonidegib) are recommended. If there's disease progression or intolerance to Hedgehog inhibitors, immunotherapy with anti-PD1 antibody (cemiplimab) can be considered. Radiotherapy is a good option for patients who can't have surgery, especially older patients. Electrochemotherapy could be considered if surgery or radiotherapy isn't an option.
Risikofaktore sluit in blootstelling aan ultravioletlig, bestralingsterapie, langtermyn blootstelling aan arseen en swak immuunstelselfunksie (bv. orgaanoorplanting). Blootstelling aan UV-lig tydens die kinderjare is veral skadelik.
Na diagnose deur biopsie, is behandeling tipies deur chirurgiese verwydering. Dit kan deur eenvoudige uitsny gebeur as die kanker klein is; As die kanker nie klein is nie, word Mohs-operasie oor die algemeen aanbeveel.
Basaalselkarsinoom is verantwoordelik vir ten minste 32% van alle kankers wêreldwyd. Van ander velkankers as melanoom is ongeveer 80% basale sel kankers. In die Verenigde State word ongeveer 35% van wit mans en 25% van wit wyfies op 'n stadium in hul lewens deur basaalselkarsinoom geraak.
○ Diagnose en behandeling
#Dermoscopy
#Skin biopsy
#Mohs surgery