Dysplastic nevus - Displastiese Nevus
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Dysplastic nevi ― Biopsie word aanbeveel vir Westerlinge.
References
Dysplastic nevus , ook bekend as 'n atipiese of Clarks nevus, het debatte in dermatologie en dermatopatologie ontketen. Dokters biopsie dikwels hierdie moesies omdat hulle abnormaal kan lyk en kommer oor melanoom kan wek.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
Dysplastic nevi , ook bekend as atipiese of Clark nevi, kan soms lei tot melanoom. Ongeveer 36% van melanome word naby displastiese nevi gevind. Tekens dat 'n displastiese nevus in melanoom kan verander, sluit in ongelyke vorm, meer pigmentveranderinge of 'n gryserige kleur. Hierdie kankers gebeur gewoonlik op 'n jonger ouderdom (omstreeks die middel van die dertigerjare) , kan veelvuldig wees en is dikwels op die stam. Geneties is dysplastic nevi tussen benigne nevi en melanoom. Slegs 20% tot 30% van melanome kom egter van bestaande nevi. Aangesien die meeste nevi nie melanoom word nie, word dit gewoonlik nie aanbeveel om dit voorkomend te verwyder nie.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
'n Melanoom is 'n tipe gewas wat vorm wanneer melanosiete, selle wat verantwoordelik is vir velkleur, kankeragtig word. Melanosiete kom van die neurale kruin af. Dit beteken dat melanome nie net op die vel kan ontwikkel nie, maar ook in ander areas waar neurale kuifselle migreer, soos die spysverteringskanaal en brein. Die oorlewingsyfer vir pasiënte met vroeë stadium melanoom (stadium 0) is hoog op 97%, terwyl dit aansienlik daal tot ongeveer 10% vir diegene wat met gevorderde stadium siekte (stadium IV) gediagnoseer is.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
○ Kankerrisiko
Soos gesien in Kaukasiese individue in die Verenigde State, het diegene met displastiese nevi 'n lewenslange risiko om melanoom van meer as 10% te ontwikkel. Aan die ander kant het diegene sonder enige displastiese nevus 'n risiko om melanoom van minder as 1% te ontwikkel.
○ Voorsorgmaatreël vir individue met displastiese nevi
Velselfondersoek word gewoonlik aanbeveel om melanoom te voorkom (deur atipiese nevi te identifiseer wat verwyder kan word) of vir vroeë opsporing van bestaande gewasse. Mense met 'n persoonlike of familiegeskiedenis van velkanker of van veelvuldige atipiese nevi moet 'n dermatoloog ten minste een keer per jaar sien om seker te wees dat hulle nie melanoom ontwikkel nie.
Die afkorting [ABCDE] was nuttig om gesondheidsorgverskaffers en leke te help om die sleutelkenmerke van 'n melanoom te onthou. Ongelukkig vir die gemiddelde persoon, kan baie seborrheic keratoses, sommige lentigo senilis, en selfs vratte [ABCDE] eienskappe hê, en kan nie van 'n melanoom onderskei word nie.
○ [ABCDE]
Asymmetrical: Asimmetriese velletsel.
Border: Die rand van die letsel is onreëlmatig.
Color: melanome het gewoonlik veelvuldige onreëlmatige kleure.
Diameter: nevi groter as 6 mm is meer geneig om melanome te wees as kleiner nevi.
Evolution: Die evolusie (m.a.w. verandering) van 'n nevus of letsel kan daarop dui dat die letsel kwaadaardig word.