Herpes zoster - Gordelroos
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Herpes zoster blase op die nek en skouer
References
Gordelroos, wat veroorsaak word deur die heraktivering van die varicella zoster-virus wat verantwoordelik is vir waterpokkies, raak jaarliks ongeveer 1 miljoen mense in die Verenigde State, met 'n leeftydrisiko van 30%. Diegene met verswakte immuunstelsels is aansienlik meer geneig om gordelroos te ontwikkel, met simptome wat tipies begin met malaise, hoofpyn en 'n ligte koors, gevolg deur ongewone velsensasies 'n paar dae voor die verskyning van 'n uitslag. Hierdie uitslag, wat gewoonlik in 'n spesifieke area van die liggaam voorkom, vorder oor 'n week tot tien dae van duidelike blase tot gekorsde sere. Vinnige behandeling met antivirale medikasie (acyclovir, valacyclovir, or famciclovir) binne 72 uur na die aanvang van uitslag is van kardinale belang. Postherpetiese neuralgie, 'n algemene komplikasie wat gekenmerk word deur langdurige pyn in die aangetaste area, raak ongeveer een uit elke vyf pasiënte en vereis deurlopende behandeling met medikasie soos gabapentien, pregabalien of sekere antidepressante, saam met aktuele middels soos lidokaïen of capsaïcine. Inenting teen die varicella zoster-virus word aanbeveel vir volwassenes van 50 en ouer om die risiko van gordelroos te verminder.
Shingles, caused by the reactivation of the varicella zoster virus responsible for chickenpox, affects around 1 million people annually in the United States, with a lifetime risk of 30%. Those with weakened immune systems are significantly more prone to developing shingles, with symptoms typically starting with malaise, headache, and a mild fever, followed by unusual skin sensations a few days before the appearance of a rash. This rash, usually appearing in a specific area of the body, progresses from clear blisters to crusted sores over a week to ten days. Prompt treatment with antiviral medications (acyclovir, valacyclovir, or famciclovir) within 72 hours of rash onset is crucial. Postherpetic neuralgia, a common complication characterized by prolonged pain in the affected area, affects about one in five patients and requires ongoing management with medications such as gabapentin, pregabalin, or certain antidepressants, along with topical agents like lidocaine or capsaicin. Vaccination against the varicella zoster virus is recommended for adults aged 50 and above to reduce the risk of shingles.
Shingles, caused by the reactivation of the varicella zoster virus responsible for chickenpox, affects around 1 million people annually in the United States, with a lifetime risk of 30%. Those with weakened immune systems are significantly more prone to developing shingles, with symptoms typically starting with malaise, headache, and a mild fever, followed by unusual skin sensations a few days before the appearance of a rash. This rash, usually appearing in a specific area of the body, progresses from clear blisters to crusted sores over a week to ten days. Prompt treatment with antiviral medications (acyclovir, valacyclovir, or famciclovir) within 72 hours of rash onset is crucial. Postherpetic neuralgia, a common complication characterized by prolonged pain in the affected area, affects about one in five patients and requires ongoing management with medications such as gabapentin, pregabalin, or certain antidepressants, along with topical agents like lidocaine or capsaicin. Vaccination against the varicella zoster virus is recommended for adults aged 50 and above to reduce the risk of shingles.
Herpes zoster is geneig om meer gereeld voor te kom by mense van 50 jaar en ouer, diegene met verswakte immuunstelsels en diegene wat immuunonderdrukkende medikasie neem. Dit word veroorsaak deur die heraktivering van die varicella-zoster-virus, dieselfde virus wat waterpokkies veroorsaak. Simptome soos koors, pyn en jeuk gaan gewoonlik die verskyning van die kenmerkende uitslag vooraf. Die mees algemene komplikasie is post-herpetiese neuralgie, wat aanhoudende senuweepyn is nadat die uitslag opgeklaar het. Die risikofaktore en komplikasies wat met herpes zoster geassosieer word, wissel na gelang van ouderdom, immuungesondheid en tydsberekening van die aanvang van behandeling. Daar is getoon dat inenting vir individue van 60 en ouer die voorkoms van herpes zoster en post-herpetiese neuralgie aansienlik verminder. As jy antivirale medikasie en pynstillers binne 72 uur na die aanvang van die uitslag begin, kan dit die erns en komplikasies van herpes zoster en post-herpetiese neuralgie verminder.
Herpes zoster tends to occur more frequently in people aged 50 and older, those with weakened immune systems, and those taking immunosuppressant medications. It's triggered by the reactivation of the varicella-zoster virus, the same virus that causes chickenpox. Symptoms like fever, pain, and itching commonly precede the appearance of the characteristic rash. The most common complication is post-herpetic neuralgia, which is persistent nerve pain after the rash clears up. The risk factors and complications associated with herpes zoster vary depending on age, immune health, and timing of treatment initiation. Vaccination for individuals aged 60 and above has been shown to significantly reduce the occurrence of herpes zoster and post-herpetic neuralgia. Starting antiviral medications and pain relievers within 72 hours of rash onset can lessen the severity and complications of herpes zoster and post-herpetic neuralgia.
Herpes zoster tends to occur more frequently in people aged 50 and older, those with weakened immune systems, and those taking immunosuppressant medications. It's triggered by the reactivation of the varicella-zoster virus, the same virus that causes chickenpox. Symptoms like fever, pain, and itching commonly precede the appearance of the characteristic rash. The most common complication is post-herpetic neuralgia, which is persistent nerve pain after the rash clears up. The risk factors and complications associated with herpes zoster vary depending on age, immune health, and timing of treatment initiation. Vaccination for individuals aged 60 and above has been shown to significantly reduce the occurrence of herpes zoster and post-herpetic neuralgia. Starting antiviral medications and pain relievers within 72 hours of rash onset can lessen the severity and complications of herpes zoster and post-herpetic neuralgia.
Die kliniese proewe voor goedkeuring dui daarop dat die lewende zoster-entstof ongeveer 50 tot 70% werk, terwyl die rekombinante entstof beter presteer, wat wissel van 90 tot 97%. In werklike studies ondersteun hulle die bevindinge van die proewe, wat toon dat die lewende entstof ongeveer 46% doeltreffend is, terwyl die rekombinante een ongeveer 85% is.
The pre-licensure clinical trials show the efficacy of the live zoster vaccine to be between 50 and 70% and for the recombinant vaccine to be higher at 90 to 97%. Real-world effectiveness studies, with a follow-up of approximately 10 years, were reviewed in this article. These data corroborated the efficacy studies, with vaccine effectiveness being 46% and 85% for the live and recombinant vaccines, respectively.
The pre-licensure clinical trials show the efficacy of the live zoster vaccine to be between 50 and 70% and for the recombinant vaccine to be higher at 90 to 97%. Real-world effectiveness studies, with a follow-up of approximately 10 years, were reviewed in this article. These data corroborated the efficacy studies, with vaccine effectiveness being 46% and 85% for the live and recombinant vaccines, respectively.
Waterpokkies, ook genoem varicella, is die gevolg van die aanvanklike infeksie met die virus, wat gewoonlik tydens die kinderjare of adolessensie voorkom. Sodra die waterpokkies genees is, kan die virus vir jare of dekades onaktief (dormant) in menslike senuweeselle bly, waarna dit weer kan aktiveer. gordelroos (herpes zoster) ontstaan wanneer die dormante varicellavirus heraktiveer word. Dan beweeg die virus langs senuliggame na senuwee-eindpunte in die vel, wat blase veroorsaak. Tydens 'n uitbreking van gordelroos (herpes zoster) kan blootstelling aan die varicella-virus wat in gordelroos (herpes zoster) -blase voorkom, waterpokkies veroorsaak by iemand wat nog nie waterpokkies gehad het nie.
Risikofaktore vir heraktivering van die dormante virus sluit in ouderdom, swak immuunfunksie en om waterpokkies voor 18 maande oud te kry. Varicella zoster-virus is nie dieselfde as herpes simplex-virus nie, alhoewel albei aan dieselfde familie van herpesvirusse behoort.
gordelroos (herpes zoster) -entstowwe verminder die risiko van gordelroos (herpes zoster) met 50% tot 90%. Dit verminder ook die tempo van postherpetiese neuralgie, en, indien gordelroos (herpes zoster) voorkom, die erns daarvan. As gordelroos (herpes zoster) ontwikkel, kan antivirale medikasie soos aciklovir die erns en duur van die siekte verminder as dit binne 72 uur na die verskyning van die uitslag begin word.
○ Behandeling
As die letsels vinnig versprei, sien jou dokter so gou as moontlik vir antivirale behandeling.
Beide antivirale middels en neuralgiemedikasie word benodig. Jy moet rus en ophou alkohol drink.
#Acyclovir
#Fancyclovir
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#Gabapentin
#Pregabalin