Intraepithelial carcinoma (Bowen disease)
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Tipiese geval ― Intraepithelial carcinoma (Bowen disease) kan verkeerd gediagnoseer word as 'n langdurige, nie-jeukerige ekseem.
References
Bowen's disease (BD) is 'n tipe velkanker wat in die buitenste laag van die vel (epidermis) begin. Dit is meer algemeen in Kaukasiërs en kom dikwels voor in gebiede wat aan sonlig blootgestel word, maar dit kan ook elders voorkom. BD verskyn tipies as 'n enkele letsel. BD word dikwels gesien as 'n waarskuwingsteken voordat 'n meer ernstige tipe velkanker ontwikkel. Om BD te diagnoseer, maak dokters gewoonlik staat op die ondersoek van weefselmonsters onder 'n mikroskoop (biopsie) .
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease raak meestal wit individue ouer as 60. Sleutelrisikofaktore sluit in langtermyn sonblootstelling, verswakte immuunstelsel, arseenblootstelling en vel HPV-infeksie. HPV-stamme 16, 18, 34 en 48 word gekoppel aan Bowen se siekte in genitale areas. Die betrokkenheid van HPV in nie-genitale gevalle is minder duidelik.
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
Dit verskyn gewoonlik as 'n eritematiese, skubberige of korsagtige area op enige plek op die liggaam. Die mees algemene plek is onderbene.
Dit is geneesbaar deur verskeie behandelingsopsies soos krioterapie, curettage, koutering, fotodinamiese terapie of uitsny van die letsel.
○ Diagnose en behandeling
#Dermoscopy
#Skin biopsy
#Mohs surgery
#Photodynamic therapy