Livedoid vasculitis - Livedoid Vaskulitis
Livedoid Vaskulitis (Livedoid vasculitis) is 'n chroniese kutane siekte wat hoofsaaklik by jong tot middeljarige vroue gesien word. Een akroniem wat gebruik word om sy kenmerke te beskryf, is "Pynlike purpuriese ulkusse met retikulêre patroon van die onderste ledemate" (PURPLE). Dit word geassosieer met 'n aantal siektes, insluitend chroniese veneuse hipertensie en spatare.
☆ In die 2022 Stiftung Warentest-resultate van Duitsland was verbruikerstevredenheid met ModelDerm net effens laer as met betaalde telemedisyne-konsultasies.
Dit kan met pyn gepaardgaan.
References
Livedoid vasculopathy is 'n seldsame veltoestand wat gekenmerk word deur pynlike ulkusse wat aanhou terugkom op die onderbene.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy is 'n seldsame veltoestand wat herhalende maagsere op die onderbene veroorsaak, wat bleek letsels, bekend as atrophie blanche, agterlaat. Alhoewel die presiese oorsaak nog onduidelik is, word geglo dat verhoogde bloedstolling (hypercoagulability) die hooffaktor is, met inflammasie wat 'n sekondêre rol speel. Faktore wat bydra tot stolling sluit die volgende in - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsie toon die toestand bloedklonte binne vate, verdikking van vaatwande en littekens. Behandeling behels 'n veelvoudige benadering wat fokus op die voorkoming van bloedklonte met medikasie soos anti-plaatjie-middels, bloedverdunners en fibrinolitiese terapie. Verskeie middels kan vir hierdie veltoestand gebruik word - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is 'n seldsame toestand waar letsels op albei bene voorkom. Die vorming van bloedklonte in piepklein bloedvate word vermoedelik veroorsaak deur verhoogde stolling en verminderde klontafbreking, tesame met skade aan die vaatvoering. Dit is meer algemeen by vroue, veral tussen die ouderdomme van 15 en 50. Om op te hou rook, wonde te versorg, en medikasie soos bloedverdunner en antiplaatjiemiddels was doeltreffend.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
