Melasmahttps://en.wikipedia.org/wiki/Melasma
Melasma is 'n bruin of donker velverkleuring van die gesig. Melasma word vermoedelik veroorsaak deur sonblootstelling, genetiese aanleg, hormoonveranderinge en velirritasie. Alhoewel dit enigiemand kan raak, is dit veral algemeen by vroue, veral swanger vroue en diegene wat voorbehoedmiddels of hormoonvervangingsterapiemedikasie gebruik.

Melasma kan nie vir 'n sekere tydperk met laserbehandeling opgelos word nie, aangesien dit 'n siekte is waarin pigment voortdurend geproduseer word. Tranxenemic suur help om te verbeter om die pigmentasie te verminder.

Behandeling
In sommige lande (bv. Japan, Korea) is orale traneksamensuur oor die toonbank beskikbaar en is dit effektief. Die melasmaroom met tranexamiese suur en azelaïensuur kan gedeeltelik nuttig wees.
Hidrokinoon kan plaaslik gebruik word vir die behandeling van hiperpigmentasie, maar die FDA het die OTC-produkte wat hidrokinoon bevat vanaf 2020 gestop.
#Tranexamic acid [TRANSINO]

#Laser toning technique (low fluence QS1064 laser)
#Triluma
☆ In die 2022 Stiftung Warentest-resultate van Duitsland was verbruikerstevredenheid met ModelDerm net effens laer as met betaalde telemedisyne-konsultasies.
  • Dit is 'n algemene toestand wat by Asiatiese vroue in hul vroeë 40's waargeneem word. Die omcirkelde letsel op die foto is nader aan lentigo eerder as melasma.
    References Efficacy and Safety of Tranexamic Acid in Melasma: A Meta-analysis and Systematic Review 28374042
    Tranexamic acid is a novel treatment option for melasma; however, there is no consensus on its use. This systematic review searched major databases for relevant publications to March 2016. Eleven studies with 667 participants were included. Pooled data from tranexamic acid-only observational studies with pre- and post-treatment Melasma Area and Severity Index (MASI) showed a decrease of 1.60 in MASI after treat?ment with tranexamic acid. The addition of tranexamic acid to routine treatment modalities resulted in a further decrease in MASI of 0.94. These results support the efficacy and safety of tranexamic acid, either alone or as an adjuvant to routine treatment modalities for melasma.
     The Low-Fluence Q-Switched Nd:YAG Laser Treatment for Melasma: A Systematic Review 35888655 
    NIH
    Onlangs het low-fluence Q-switched Nd:YAG (LFQSNY) laser gewild geword vir die behandeling van melasma, veral in Asië. Om uiteenlopende studies op te som was uitdagend, maar LFQSNY lyk oor die algemeen effektief en veilig vir melasma in vergelyking met tradisionele terapieë. Sommige gevalle van gevlekte hipopigmentasie is egter aangemeld as 'n newe-effek van LFQSNY, moontlik as gevolg van hoë laserenergie. Aggressiewe gebruik van LFQSNY kan ook lei tot hiperpigmentasie van inflammasie, veral in donkerder velkleure.
    Recently, the low-fluence Q-switched Nd:YAG laser (LFQSNY) has been widely used for treating melasma, especially in Asia. It was hard to summarize the heterogenous studies, but LFQSNY appeared to be a generally effective and safe treatment for melasma considering the results of previous conventional therapies. However, mottled hypopigmentation has been occasionally reported to develop and persist as an adverse event of LFQSNY, which may be associated with the high accumulated laser energy. When used aggressively, even LFQSNY can induce hyperpigmentation via unwanted inflammation, especially in darker skin.
     Pigmentation Disorders: Diagnosis and Management 29431372
    Pigmentasieprobleme word dikwels in primêre sorg gevind. Algemene tipes hiperpigmentasieversteurings sluit post-inflammatory hyperpigmentation, melasma, sunspots, freckles, café au lait spots in.
    Pigmentation problems are often found in primary care. Common types of hyperpigmentation disorders include post-inflammatory hyperpigmentation, melasma, sunspots, freckles, café au lait spots.