Prurigo nodularis
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References
Prurigo nodularis is 'n langdurige veltoestand wat gekenmerk word deur veelvuldige stewige knoppe en knoppies, wat gewoonlik op die buitenste dele van die arms en bene voorkom. Hierdie knoppe kan in kleur wissel van vleeskleur tot pienk en is intens jeukerig. Hulle kan mense van enige ouderdom affekteer en word dikwels gekoppel aan ander veltoestande wat chroniese jeuk veroorsaak, soos atopiese dermatitis. Behandelingsopsies sluit in sterk anti-jeuk medikasie, middels wat die immuunstelsel beïnvloed, en medikasie wat die senuweestelsel teiken. Die bestuur van die prurigo nodularis behels gewoonlik langtermynterapie.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Behandeling behels gewoonlik die gebruik van ys of inspuitings van steroïede op die geaffekteerde area. In meer ernstige of hardnekkige gevalle kan behandelings soos ligterapie of medikasie wat die immuunstelsel onderdruk nodig wees. Thalidomied en lenalidomied is opsies vir ernstige gevalle, maar hulle kan ernstige newe-effekte hê. Nuwer behandelings (opioid receptor antagonists, neurokinin-1 receptor antagonists) toon belofte in die behandeling van prurigo nodularis met minder newe-effekte in vergelyking met talidomied of lenalidomied.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Chronic prurigo is 'n veltoestand wat gekenmerk word deur langdurige jeuk (wat langer as 6 weke duur) , krapverwante velletsels en 'n geskiedenis van gereelde krap. Dit behels neuro-inflammasie en fibrose in die vel.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Prurigo nodularis is 'n langdurige velprobleem wat gekenmerk word deur jeukerige knoppies. Ons weet nie presies wat dit veroorsaak nie, maar dit blyk dat immuun- en senuweekwessies 'n rol speel in die jeuk-krap-siklus. Op die oomblik is daar geen behandelings wat spesifiek vir prurigo nodularis deur die Amerikaanse FDA goedgekeur is nie.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
○ Behandeling ― OTC-dwelms
Om die letselarea met seep te was help glad nie en kan dit vererger. OTC-steroïedsalf kan help om die simptome te verlig, maar dit moet gewoonlik vir 'n paar weke toegedien word om te verbeter. Om voort te gaan om antihistamiene te neem, help ook om die jeuk te verlig.
#OTC steroid ointment
#OTC antihistamine
○ Behandeling
#Intralesional triamcinolone injection