Syphilis - Sifilis
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Chancres ― primêre sifilitiese infeksie deur Treponema pallidum
References
Sifilis is 'n seksueel oordraagbare siekte wat deur die bakterie Treponema pallidum veroorsaak word. In hierdie studie fokus ons op 57 pasiënte tussen die ouderdomme 18-68 met sekondêre sifilis.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Sifilis is 'n bakteriële infeksie wat veroorsaak word deur Treponema pallidum. Dit kan verskeie siektes naboots, wat dit die bynaam great imitator verdien. Sifilis raak steeds miljoene wêreldwyd, maar kan doeltreffend met penisillien behandel word.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Treponema pallidum veroorsaak sifilis deur seksuele kontak of van ma tot baba tydens swangerskap. Al is daar eenvoudige toetse om dit te diagnoseer en werk behandeling met een langwerkende penisillieninspuiting goed, is sifilis besig om wêreldwyd weer ’n groot probleem te word. Dit is veral waar onder mans wat seks met mans (MSM) het in lande met hoë en middelinkomste. Terwyl sommige lae-inkomstelande die WGO se doelwitte bereik het om te keer dat sifilis van moeder na baba oorgedra word, is daar 'n kommerwekkende toename in sifilis onder MIV-positiewe MSM.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
(1) Vergrote lewer: Dit word dikwels gevind en kan langs 'n vergrote milt gebeur. Die ondersoek van 'n lewerbiopsie onder donkerveldmikroskopie kan die teenwoordigheid van die spirogeet aan die lig bring. Lewerfunksietoetse kan abnormaliteite toon. (2) Vergeling van die vel (Geelsug) : Of iemand geelsug toon, hang af van hoeveel die lewer aangetas is. (3) Loopneus: Dikwels een van die eerste tekens, gewoonlik binne die eerste week na geboorte. (4) Geswelde limfknope: Algemene swelling van limfknope, gewoonlik pynloos, is ook algemeen. (5) Veluitslag: 'n Uitslag verskyn tipies een tot twee weke na die loopneus. Jy sal dalk klein rooi of pienk kolle op die rug, boude, dye en voetsole sien. Hierdie uitslag kan vorder tot afskilfering en korsvorming.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
○ Diagnose en behandeling
VDRL en RPR kan gebruik word om onlangse infeksie te bevestig en vir sifilis te skerm. FTA-ABS-toets is 'n meer spesifieke toets en kan gebruik word om na vorige infeksiegeskiedenis te kyk. Penisillien word gebruik om sifilis te behandel.