Urticaria pigmentosa
Urticaria pigmentosa is die mees algemene vorm van kutane mastositose. Dit is 'n seldsame siekte wat veroorsaak word deur oormatige getalle mastselle in die vel wat korwe of letsels op die vel produseer wanneer dit geïrriteerd word. Rooi of bruin kolle word dikwels op die vel gesien, gewoonlik rondom die bors, voorkop en rug. Hierdie mastselle, wanneer geïrriteerd (bv. deur die vel te vryf, hitte blootstelling), produseer te veel histamien, wat 'n allergiese reaksie veroorsaak wat lei tot korwe wat gelokaliseer is na die area van irritasie, wat soms na verwys word as "Darier se teken".
☆ In die 2022 Stiftung Warentest-resultate van Duitsland was verbruikerstevredenheid met ModelDerm net effens laer as met betaalde telemedisyne-konsultasies.
Dit is geneig om op die bolyf van jong kinders te voorkom.
References
Mastocytosis is 'n toestand waar daar 'n oormaat mastselle is, wat dikwels in verskeie liggaamsdele soos die vel, beenmurg en spysverteringstelsel voorkom. Volgens die Wêreldgesondheidsorganisasie (WGO) kan cutaneous mastocytosis in drie hooftipes gekategoriseer word. Die eerste tipe (mastocytomas) bestaan uit eensame of 'n paar (≤3) letsels. Die tweede tipe (urticaria pigmentosa) behels veelvuldige letsels, wat tipies wissel van meer as 10 tot minder as 100. Die laaste tipe toon wydverspreide betrokkenheid oor die vel. Urticaria pigmentosa is die mees algemene vorm van kutane mastositose by kinders, maar dit kan ook by volwassenes voorkom. Dit is gewoonlik 'n onskadelike toestand wat dikwels tydens adolessensie verbeter. Anders as volwasse mastositose, raak urticaria pigmentosa selde interne organe. Een kenmerkende kenmerk van urticaria pigmentosa is sy neiging om klein, jeukerige, rooibruin of geelbruin kolle of letsels op die vel te veroorsaak, algemeen bekend as korwe. Hierdie kolle verskyn gewoonlik in die kinderjare en kan lewenslank aanhou.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
’n 6-jarige meisie het ingekom met verskeie donkerkleurige kolle wat eers op haar kopvel verskyn het en toe oor die afgelope ses maande na haar gesig en lyf versprei het. Sy het genoem hoe hulle opstyg, rooi word en jeuk wanneer druk toegepas word. Sy het nie spoel, braking, diarree of hyg ervaar nie, en haar persoonlike en familie mediese geskiedenis het nie relevante leidrade verskaf nie. Met ondersoek het ons verskeie donker kolle op haar kopvel, voorkop, gesig en nek gevind, saam met effens verhewe donker kolle op haar bors en rug. Deur die kolle liggies te vryf, het hulle binne 2 minute laat swel en jeuk, maar die simptome het binne 15–20 minute verdwyn (Darier's sign) .
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
