Acute generalized exanthematous pustulosis
Acute generalized exanthematous pustulosis (AGEP) ያልተለመደ የቆዳ ምላሽ ሲሆን በ90% ከሚሆኑት ጉዳዮች ከመድኃኒት አስተዳደር ጋር የተያያዘ ነው። acute generalized exanthematous pustulosis መድሃኒት ከተጀመረ ከአምስት ቀናት በኋላ በአማካይ በሚታዩ ድንገተኛ የቆዳ ፍንዳታዎች ይታወቃል. እነዚህ ፍንዳታዎች ብጉር ናቸው፣ ማለትም ትንሽ ቀይ ነጭ ወይም ቀይ የቆዳ ፍንዳታ ደመናማ ወይም ማፍረጥ (pus) የያዘ። የቆዳ ቁስሎች ብዙውን ጊዜ አጸያፊውን መድሃኒት ካቆሙ ከ1-3 ቀናት ውስጥ ይጠፋሉ.
☆ እ.ኤ.አ. በ 2022 ከጀርመን የስቲፍቱንግ ዋረንቴስት ውጤቶች ፣ በሞዴልደርም የተገልጋዮች እርካታ ከሚከፈልባቸው የቴሌሜዲኬን ምክሮች በትንሹ ያነሰ ነበር።
erythema እና pustules ያላቸው ሰፊ ቁስሎች በድንገት ይታያሉ።
References
Acute generalized exanthematous pustulosis (AGEP) በቀይ የቆዳ መሠረት ላይ በትንንሽ ፣ መግል በተሞሉ እብጠቶች ተለይቶ የሚታወቅ የቆዳ ምላሽ ነው። ብዙውን ጊዜ አንድ ሰው እንደ አንቲባዮቲክ ያሉ አንዳንድ መድሃኒቶችን ሲወስድ እና በፍጥነት በሰውነት ላይ ሲሰራጭ ይከሰታል. ቀስቅሴውን መድሃኒት ካቆሙ በኋላ, ምልክቶቹ ብዙውን ጊዜ በሁለት ሳምንታት ውስጥ ይጠፋሉ, ብዙውን ጊዜ የተወሰነ ቆዳ ይተዋል. ምንም እንኳን ብዙውን ጊዜ ከባድ እና በቆዳ ላይ ብቻ የተገደበ ባይሆንም ፣ ከባድ የሆኑ ጉዳዮች እንደ Stevens-Johnson syndrome ወይም toxic epidermal necrolysis ካሉ ሌሎች ከባድ የቆዳ ምላሾች ጋር ሊጣመሩ ይችላሉ። ሕክምናው በዋነኛነት ደጋፊ እንክብካቤ ነው, እና በሽታውን ሙሉ በሙሉ ለመፍታት ትንበያው ብዙውን ጊዜ በጣም ጥሩ ነው.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
አንድ የ76 ዓመት ሰው ወደ ድንገተኛ ክፍል የመጣው ባለፉት ሁለት ቀናት ውስጥ ቆዳቸው ስለተለወጠ ነው። ዶክተሮች ግንዱ እና እጆቹ እና እግሮቹ ላይ ቀይ ሽፋኖችን እና ከፍ ያሉ ቦታዎችን አግኝተዋል. ጊዜ እያለፈ ሲሄድ እነዚህ ንጣፎች አንድ ላይ ተጣመሩ እና በቀይ ቦታዎች ላይ ብጉር የሚመስሉ እብጠቶችን ፈጠረ. በምርመራዎች ከፍተኛ የነጭ የደም ሴሎች ብዛት ኒውትሮፊል ተብለው የሚጠሩ ብዙ አይነት እና C-reactive protein ጨምረዋል።
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
