ተጨማሪ መረጃ ― አማርኛ

አንዲት የ26 ዓመቷ ሴት ለ10 ዓመታት እግሮቿ ላይ ስለደረሰባት ሽፍታ ስታማርር ወደ ክሊኒካችን መጣች። የስቴሮይድ ክሬም እና ታዛሮቲን ክሬም ቢጠቀሙም, ሽፍታው አልተሻለውም. ምንም ተዛማጅ የቤተሰብ ታሪክ አልነበራትም። ስንመረምራት በእግሯ ፊት ላይ ከፍ ያሉ እና ሻካራ ንጣፎችን አገኘናት፤ እነሱም lichen amyloidosis ከተባለ በሽታ ጋር ይመሳሰላሉ።
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.

Lichen Amyloidosis ብዙውን ጊዜ እንደ አቶፒክ ዲርማቲቲስ (atopic dermatitis) ይታወቃል። እሱ ብዙውን ጊዜ በቆዳው ውጫዊ ገጽታዎች ላይ እንደ የተነሱ፣ ቀለም የተቀቡ ቁርጥራጮች ሆኖ ይታያል። Lichen Amyloidosis ብዙውን ጊዜ ከ 50 እስከ 60 ዓመት በሆኑ ሰዎች ላይ ይታያል እና በሚያሳዝን ሁኔታ, ምንም መድሃኒት የለም. አሁን ያሉት ሕክምናዎች ብዙ ጊዜ በደንብ አይሰሩም።
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.

Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.