Dysplastic nevus
☆ እ.ኤ.አ. በ 2022 ከጀርመን የስቲፍቱንግ ዋረንቴስት ውጤቶች ፣ በሞዴልደርም የተገልጋዮች እርካታ ከሚከፈልባቸው የቴሌሜዲኬን ምክሮች በትንሹ ያነሰ ነበር።
Dysplastic nevi ― ባዮፕሲ ለምዕራባውያን ይመከራል።
References
Dysplastic nevus ፣ በተጨማሪም ኤቲፒካል ወይም ክላርክ ኔቩስ በመባል የሚታወቀው፣ በቆዳ ህክምና እና በቆዳ ህክምና ላይ ክርክሮችን አስነስቷል። ዶክተሮች ያልተለመዱ ሊመስሉ ስለሚችሉ እና ስለ ሜላኖማ ስጋት ስለሚፈጥሩ ብዙውን ጊዜ እነዚህን ሞሎች ባዮፕሲ ያደርጋሉ።
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
Dysplastic nevi ፣ በተጨማሪም ኤቲፒካል ወይም ክላርክ ኔቪ በመባል የሚታወቀው፣ አንዳንድ ጊዜ ወደ ሜላኖማ ሊያመራ ይችላል። 36 በመቶው ሜላኖማ በ dysplastic nevi አቅራቢያ ይገኛሉ። dysplastic nevus ወደ ሜላኖማ ሊለወጥ እንደሚችል የሚያሳዩ ምልክቶች ያልተስተካከለ ቅርጽ፣ ተጨማሪ የቀለም ለውጦች ወይም ግራጫማ ቀለም ያካትታሉ። እነዚህ ካንሰሮች ብዙውን ጊዜ በለጋ እድሜያቸው (በሰላሳዎቹ አጋማሽ አካባቢ) ይከሰታሉ፣ ብዙ ሊሆኑ ይችላሉ፣ እና ብዙ ጊዜ ግንዱ ላይ ናቸው። በዘረመል፣ dysplastic nevi በ benign nevi እና melanoma መካከል ናቸው። ነገር ግን ከ20% እስከ 30% የሚሆኑ ሜላኖማዎች ከነባር ኔቪ የሚመጡ ናቸው።
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
ሜላኖማ ለቆዳ ቀለም ተጠያቂ የሆኑት ሜላኖይተስ ሴሎች ካንሰር ሲሆኑ የሚፈጠር ዕጢ ዓይነት ነው። ሜላኖይተስ የሚመነጨው ከነርቭ ክሬስት ነው። ይህ ማለት ሜላኖማ በቆዳ ላይ ብቻ ሳይሆን እንደ የጨጓራና ትራክት እና አንጎል ባሉ ሌሎች የነርቭ ሴሎች በሚፈልሱባቸው አካባቢዎችም ሊዳብር ይችላል። በቅድመ-ደረጃ ሜላኖማ (ደረጃ 0) ለታካሚዎች የመዳን መጠን በ 97% ከፍ ያለ ሲሆን በከፍተኛ ደረጃ ላይ ያሉ በሽታዎች (ደረጃ IV) ለታወቁት ደግሞ ወደ 10% ገደማ ይቀንሳል.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
○ የካንሰር አደጋ
በዩናይትድ ስቴትስ ውስጥ በካውካሲያን ግለሰቦች ላይ እንደሚታየው, dysplastic nevi ያለባቸው ሰዎች እድሜ ልክ ከ 10% በላይ የሆነ ሜላኖማ የመያዝ ዕድላቸው አላቸው. በሌላ በኩል፣ ምንም ዓይነት ዲስፕላስቲክ ኒቫስ የሌላቸው ከ1 በመቶ በታች የሆነ የሜላኖማ በሽታ የመያዝ እድላቸው ከፍተኛ ነው።
○ ጥንቃቄ ዲስፕላስቲክ nevi
ሜላኖማ (ሜላኖማ)ን ለመከላከል (የሚወገድ ያልተለመደ ኔቪን በመለየት) ወይም ያሉትን እጢዎች አስቀድሞ ለማወቅ የቆዳ ራስን መመርመር ይመከራል። የቆዳ ካንሰር ወይም ብዙ ያልተለመደ ኔቪ ያላቸው ሰዎች ቢያንስ በዓመት አንድ ጊዜ የቆዳ ህክምና ባለሙያን ማየት እና ሜላኖማ እንዳይፈጠር ማድረግ አለባቸው።
አህጽሮተ ቃል [ABCDE] የጤና እንክብካቤ አቅራቢዎችን እና ተራ ሰዎች የሜላኖማ ዋና ዋና ባህሪያትን እንዲያስታውሱ ለመርዳት ጠቃሚ ነው። እንደ አለመታደል ሆኖ ለአማካይ ሰው ብዙ ሴቦርሬይክ keratoses ፣ አንዳንድ lentigo senilis እና ኪንታሮት እንኳን [ABCDE] ባህሪዎች ሊኖራቸው ይችላል እና ከሜላኖማ ሊለዩ አይችሉም።
○ [ABCDE]
Asymmetrical: ተመጣጣኝ ያልሆነ የቆዳ ጉዳት.
Border: የቁስሉ ድንበር መደበኛ ያልሆነ ነው.
Colorሜላኖማ ብዙውን ጊዜ ብዙ መደበኛ ያልሆኑ ቀለሞች አሏቸው።
Diameterከ6 ሚሊ ሜትር በላይ የሆነ ኒቪ ከትንሽ ኔቪ ይልቅ ሜላኖማ የመሆን ዕድላቸው ከፍተኛ ነው።
Evolutionየኒቫስ ወይም ቁስሉ ዝግመተ ለውጥ (ማለትም ለውጥ) ቁስሉ አደገኛ እየሆነ መሄዱን ሊያመለክት ይችላል።