Melasma is a tan or dark skin discoloration. Melasma is thought to be caused by sun exposure, genetic predisposition, hormone changes, and skin irritation.
Tranexamic acid is a novel treatment option for melasma; however, there is no consensus on its use. This systematic review searched major databases for relevant publications to March 2016. Eleven studies with 667 participants were included. Pooled data from tranexamic acid-only observational studies with pre- and post-treatment Melasma Area and Severity Index (MASI) showed a decrease of 1.60 in MASI after treat?ment with tranexamic acid. The addition of tranexamic acid to routine treatment modalities resulted in a further decrease in MASI of 0.94. These results support the efficacy and safety of tranexamic acid, either alone or as an adjuvant to routine treatment modalities for melasma.
በቅርቡ low-fluence Q-switched Nd:YAG (LFQSNY) ሌዘር ሜላዝማን ለማከም በተለይ በእስያ ታዋቂ ሆኗል። የተለያዩ ጥናቶችን ማጠቃለል ፈታኝ ነበር፣ ነገር ግን LFQSNY ከባህላዊ ሕክምናዎች ጋር ሲነጻጸር በአጠቃላይ ለሜላዝማ ውጤታማ እና ደህንነቱ የተጠበቀ ይመስላል። ነገር ግን፣ አንዳንድ የmottled hypopigmentation ጉዳዮች እንደ LFQSNY የጎንዮሽ ጉዳት ሪፖርት ተደርገዋል፣ ምናልባትም በከፍተኛ ሌዘር ሃይል ምክንያት። LFQSNYን ጠንከር ያለ አጠቃቀም በእብጠት በተለይም በቆዳ ቀለም ወደ hyperpigmentation ሊያመራ ይችላል። Recently, the low-fluence Q-switched Nd:YAG laser (LFQSNY) has been widely used for treating melasma, especially in Asia. It was hard to summarize the heterogenous studies, but LFQSNY appeared to be a generally effective and safe treatment for melasma considering the results of previous conventional therapies. However, mottled hypopigmentation has been occasionally reported to develop and persist as an adverse event of LFQSNY, which may be associated with the high accumulated laser energy. When used aggressively, even LFQSNY can induce hyperpigmentation via unwanted inflammation, especially in darker skin.
ማቅለሚያ ያለማቋረጥ የሚመረተው በሽታ ስለሆነ ሜላዝማ በሌዘር ሕክምና ለተወሰነ ጊዜ ሊፈታ አይችልም። tranexamic acid (ትራንስሜክ አሲድ) ቀለምን ለመቀነስ ይረዳል።
○ ህክምና
በአንዳንድ አገሮች (ለምሳሌ ጃፓን፣ ኮሪያ)፣ የአፍ ውስጥ ትራኔክሳሚክ አሲድ (tranexamic acid) በመደርደሪያ ላይ ይገኛል እና ውጤታማ ነው። ከትራኔክሳሚክ አሲድ እና ከአዝላይክ አሲድ (azelaic acid) ጋር የሚደረገው የሜላዝማ ክሬም በከፊል ጠቃሚ ሊሆን ይችላል።
ሃይድሮኩዊኖን (hydroquinone) ለከፍተኛ የቆዳ ቀለም ሕክምና በገጽታ ጥቅም ላይ ሊውል ይችላል፣ ነገር ግን FDA (የምግብ እና የውሃ አስተዳደር ባለሙያ) የኦቲሲ (OTC) ምርቶችን ከ2020 ጀምሮ አቁሟል።
#Tranexamic acid [TRANSINO]
#Laser toning technique (low fluence QS1064 laser)
#Triluma