Onychomysosis - የእግር ጣት ጥፍር ፈንገስ
☆ እ.ኤ.አ. በ 2022 ከጀርመን የስቲፍቱንግ ዋረንቴስት ውጤቶች ፣ በሞዴልደርም የተገልጋዮች እርካታ ከሚከፈልባቸው የቴሌሜዲኬን ምክሮች በትንሹ ያነሰ ነበር።
በየእግር ጣት ጥፍር ፈንገስ (Onychomysosis) የተጎዳ የእግር ጥፍር
አንድ ሰው እግር በፈንገስ ጥፍር ኢንፌክሽን አሥር ሳምንታት ወደ ቴርቢናፊን የአፍ ውስጥ መድኃኒት ኮርስ ይወስዳል። ከቀሪዎቹ የተበከሉት ምስማሮች በስተጀርባ ያለውን ጤናማ የጥፍር እድገት ባንድ ልብ ይበሉ።
References
ሥርዓታዊ ፀረ-ፈንገስ በጣም ውጤታማ ሕክምና ነው. ሜታ-ትንታኔዎች የማይኮቲክ የፈውስ መጠኖችን እንደሚከተለው ያሳያሉ፡ terbinafine = 76%, itraconazole with pulse dosing = 63%, itraconazole with continuous dosing = 59%, fluconazole =48% ። ተጓዳኝ የጥፍር መበስበስ የበለጠ የፈውስ መጠን ይጨምራል። በ ciclopirox የአካባቢ ህክምና ብዙም ውጤታማ አይደለም; ከ 60% በላይ የሆነ ውድቀት አለው.
Systemic antifungals are the most effective treatment. Meta-analyses shows mycotic cure rates as follows: terbinafine = 76%, itraconazole with pulse dosing = 63%, itraconazole with continuous dosing = 59%, fluconazole =48%. Concomitant nail debridement further increases cure rates. Topical therapy with ciclopirox is less effective; it has a failure rate exceeding 60%.
Systemic antifungals are the most effective treatment. Meta-analyses shows mycotic cure rates as follows: terbinafine = 76%, itraconazole with pulse dosing = 63%, itraconazole with continuous dosing = 59%, fluconazole =48%. Concomitant nail debridement further increases cure rates. Topical therapy with ciclopirox is less effective; it has a failure rate exceeding 60%.
Onychomycosis ምስማሮችን የሚጎዳ የፈንገስ በሽታ ነው። በdermatophytes ምክንያት ሲከሰት ቲኒያ ኡንጉዩየም ይባላል። Onychomycosis በ dermatophytes, እርሾዎች እና ሻጋታዎች ምክንያት የሚመጡ ኢንፌክሽኖችን ያጠቃልላል. በፈንገስ ኢንፌክሽን ያልተፈጠረ የጥፍር ችግር nail dystrophy ይባላል። ምንም እንኳን በሁለቱም ጥፍር እና የእግር ጣቶች ላይ ተጽዕኖ ሊያሳድር ቢችልም, የእግር ጣት ጥፍር ኦኒኮማይኮሲስ በጣም የተለመደ ነው. ይህ ጽሑፍ የእግር ጣት ጥፍር onychomycosis እንደ ተጽእኖ, ክሊኒካዊ ዓይነቶች, ደረጃዎች, ምርመራ እና ህክምና የመሳሰሉ የተለያዩ ገጽታዎችን ያብራራል. ለሕይወት አስጊ ባይሆንም ኦኒኮማይኮሲስ እንደ ሴሉላይትስ፣ ሴፕሲስ፣ የአጥንት ኢንፌክሽን፣ የሕብረ ሕዋሳት መጎዳት እና የጥፍር መጥፋት የመሳሰሉ ከባድ ችግሮች ሊያስከትል ይችላል።
Onychomycosis is a fungal infection of the nail unit. When dermatophytes cause onychomycosis, this condition is called tinea unguium. The term onychomycosis encompasses the dermatophytes, yeasts, and saprophytic mold infections. An abnormal nail not caused by a fungal infection is a dystrophic nail. Onychomycosis can infect both fingernails and toenails, but onychomycosis of the toenail is much more prevalent. Discussed in detail in this activity are all evolving facets of the topic, including disease burden, clinical types, staging, diagnosis, and management of toenail onychomycosis. While non-life-threatening, onychomycosis can lead to severe complications such as cellulitis, sepsis, osteomyelitis, tissue damage, and nail loss.
Onychomycosis is a fungal infection of the nail unit. When dermatophytes cause onychomycosis, this condition is called tinea unguium. The term onychomycosis encompasses the dermatophytes, yeasts, and saprophytic mold infections. An abnormal nail not caused by a fungal infection is a dystrophic nail. Onychomycosis can infect both fingernails and toenails, but onychomycosis of the toenail is much more prevalent. Discussed in detail in this activity are all evolving facets of the topic, including disease burden, clinical types, staging, diagnosis, and management of toenail onychomycosis. While non-life-threatening, onychomycosis can lead to severe complications such as cellulitis, sepsis, osteomyelitis, tissue damage, and nail loss.
Terbinafine ስኳሊን ኢፖክሳይዳዝ በመከላከል የፈንገስ ኢንፌክሽንን የሚዋጋ መድሀኒት ነው። ከብዙ የቆዳ ፈንገሶች ላይ ውጤታማ ሲሆን በአፍ ሲወሰድ የጥፍር ፈንገስ ለማከም የተፈቀደ ነው። እንደ ራስ ምታት እና የሆድ ጉዳዮች ያሉ አብዛኛዎቹ የጎንዮሽ ጉዳቶች ቀላል እና በራሳቸው የሚጠፉ ሲሆኑ፣ የጣዕም ለውጦች (dysgeusia) ከቀላል ወደ ከባድ ሊለያዩ ይችላሉ፣ አንዳንዴም ወደ ክብደት መቀነስ ይመራሉ። ቋሚ ጣዕም ለውጦች እምብዛም አይደሉም ነገር ግን ሪፖርት ተደርጓል.
Terbinafine is an antifungal medication that works through the inhibition of squalene epoxidase. It has activity against most dermatophytes, and it has approval for use as an oral therapy for the treatment of onychomycosis. Although most side effects are mild and self-limited, such as headache and gastrointestinal symptoms, taste disturbances (dysgeusia) can range from mild to severe, resulting in weight loss, and have rarely been reported permanent.
Terbinafine is an antifungal medication that works through the inhibition of squalene epoxidase. It has activity against most dermatophytes, and it has approval for use as an oral therapy for the treatment of onychomycosis. Although most side effects are mild and self-limited, such as headache and gastrointestinal symptoms, taste disturbances (dysgeusia) can range from mild to severe, resulting in weight loss, and have rarely been reported permanent.
Onychomycosis ምስማሮችን የሚጎዳ የፈንገስ በሽታ ነው። 90 በመቶው የእግር ጣት ጥፍር ኢንፌክሽኖች እና 75% የጣት ጥፍር ኢንፌክሽኖች የሚከሰቱት በፈንገስ (Trichophyton mentagrophytes, Trichophyton rubrum) ነው። ምልክቶቹ የጥፍር ቀለም መቀየር፣ መወፈር፣ ከጥፍር አልጋ መለየት እና ከመጠን በላይ መጨመር ናቸው። ሕክምናው በተለምዶ እንደ terbinafine ወይም itraconazole ያሉ የአፍ ውስጥ መድሃኒቶችን ያካትታል, ወቅታዊ ህክምናዎች ከመለስተኛ እስከ መካከለኛ ለሆኑ ጉዳዮች አማራጭ ናቸው.
Onychomycosis is a fungal infection of the nail unit. Approximately 90% of toenail and 75% of fingernail onychomycosis are caused by dermatophytes, notably Trichophyton mentagrophytes and Trichophyton rubrum. Clinical manifestations include discoloration of the nail, subungual hyperkeratosis, onycholysis, and onychauxis. Currently, oral terbinafine is the treatment of choice, followed by oral itraconazole. In general, topical monotherapy can be considered for mild to moderate onychomycosis.
Onychomycosis is a fungal infection of the nail unit. Approximately 90% of toenail and 75% of fingernail onychomycosis are caused by dermatophytes, notably Trichophyton mentagrophytes and Trichophyton rubrum. Clinical manifestations include discoloration of the nail, subungual hyperkeratosis, onycholysis, and onychauxis. Currently, oral terbinafine is the treatment of choice, followed by oral itraconazole. In general, topical monotherapy can be considered for mild to moderate onychomycosis.
በአፍ የሚወሰደው ፀረ ፈንገስ መድሐኒት ቴርቢናፊን በጣም ውጤታማ ሆኖ ቢታይም ተርቢናፊን ከጉበት የጎንዮሽ ጉዳት ጋር የተያያዘ ነው።
የእግር ጣት ጥፍር ፈንገስ (onychomysosis) በ 10 በመቶው የጎልማሳ ህዝብ ውስጥ ይከሰታል፣ በእድሜ የገፉ ሰዎች በብዛት ይጠቃሉ። ወንዶች ከሴቶች ይልቅ ብዙ ጊዜ ይጎዳሉ. የእግር ጣት ጥፍር ፈንገስ (onychomysosis) የጥፍር በሽታ ግማሽ ያህሉን ይወክላል። ይህ ማለት የእግር ጣት ጥፍር መበላሸት ከኦኒኮማይኮስ በስተቀር በሌሎች ምክንያቶች ሊመጣ ይችላል።
○ ህክምና ― OTC መድሃኒቶች
መድሐኒቶች ወደ ወፍራም የእግር ጣት ጥፍር ውስጥ ዘልቀው ለመግባት አስቸጋሪ ስለሆነ onychomycosisን በአካባቢያዊ መድሃኒቶች ማከም አስቸጋሪ ነው.
#Ketoconazole
#Clotrimazole
#Miconazole
#Terbinafine
#Butenafine [Lotrimin]
#Tolnaftate
○ ህክምና
የተበከለው የእግር ጣት ጥፍር ሙሉ በሙሉ እስኪወገድ ድረስ አብዛኛውን ጊዜ የረጅም ጊዜ ህክምና ያስፈልጋል.
#Terbinafine (oral)
#Itraconazole
#Efinaconazole lacquer [Jublia]
#Ciclopirox lacquer