ተጨማሪ መረጃ ― አማርኛ

Erythema nodosum is the most common form of panniculitis and is characterized by tender erythematous nodules mainly in the lower limbs on the pretibial area. The exact cause of erythema nodosum is unknown, although it appears to be a hypersensitivity response to a variety of antigenic stimuli. Although the etiology is mostly idiopathic, ruling out an underlying disease is imperative before diagnosing primary erythema nodosum. Erythema nodosum can be the first sign of a systemic disease that is triggered by a large group of processes, such as infections, inflammatory diseases, neoplasia, and/or drugs. The most common identifiable causes are streptococcal infections, primary tuberculosis, sarcoidosis, Behçet disease, inflammatory bowel disease, drugs, and pregnancy.

Panniculitis ከቆዳ ስር የሚገኘውን አዲፖዝ ቲሹን የሚያካትቱ የተለያዩ ብግነት በሽታዎች ቡድን ይመሰርታሉ። በልጆች ላይ እነዚህ በሽታዎች እምብዛም አይደሉም. ፓኒኩላይትስ በስርዓተ-ፆታ ችግር ወይም በሁለተኛ ደረጃ በኢንፌክሽን, በአሰቃቂ ሁኔታ ወይም በመድሃኒት መጋለጥ ምክንያት የሚከሰት የመጀመሪያ ደረጃ ሂደት ሊሆን ይችላል. አብዛኛዎቹ የፓኒኩላይተስ ዓይነቶች ተመሳሳይ ክሊኒካዊ አቀራረብ አላቸው (የኤቲዮሎጂ ምንም ይሁን ምን) ፣ ለስላሳ ፣ erythematous subcutaneous nodules።
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.

Panniculitis ፣ የከርሰ ምድር ስብን መበከል፣ አብዛኛውን ጊዜ የሚያቃጥሉ ኖዶች (inflammatory nodules) ጋር አብሮ ይመጣል። Erythema nodosum (EN) በክሊኒካዊ መልኩ በጣም ተደጋጋሚ የፓኒኩላይትስ አይነት ነው። እስከ 55% የሚሆነው የ EN እንደ idiopathic ይቆጠራል፣ በጣም የተለመዱት መንስኤዎች ኢንፌክሽኖች ፣ መድኃኒቶች ፣ ሥርዓታዊ እንደ sarcoidosis እና ኢንፍላማቶሪ የአንጀት በሽታ ፣ እርግዝና እና መጎሳቆል ያካትታሉ። EN በተለምዶ በአሥራዎቹ እና በ 20 ዎቹ ውስጥ ይታያል, እና በሴቶች ላይ በብዛት ይታያል. ብዙውን ጊዜ ከአንድ እስከ ሶስት ሳምንታት ባለው ልዩ ያልሆነ ፕሮድሮም ይቀድማል፣ እሱም ትኩሳት፣ ህመም እና የላይኛው የመተንፈሻ አካላት ኢንፌክሽን ምልክቶችን ሊያካትት ይችላል። የቆዳ ቁስሎች ይከተላሉ፣ በተለይም በእግሮቹ ማራዘሚያ ገጽታ ላይ ይተረጎማሉ። ቁስሎቹ የሚያሰቃዩ ክብ ቅርጽ ያላቸው ወይም ሞላላ፣ ትንሽ ከፍ ያለ፣ ቁስለት የሌላቸው ቀይ እባጮች ናቸው። የ EN ትክክለኛ በሽታ አምጪ ተህዋሲያን በትክክል አልተረዳም ፣ ምንም እንኳን የበሽታ መከላከያ ውህዶች በሴፕቴይስ ሽፋን ስር ባለው የቆዳ ስብ ውስጥ በማስቀመጥ የኒውትሮፊል ፓኒኩላይትስ ያስከትላል ተብሎ ቢታሰብም። ለምክንያታዊ ሁኔታ የተለየ ሕክምና ባይኖርም, EN በአብዛኛዎቹ ጉዳዮች ያለ ህክምና ይፈታል.
Panniculitis, inflammation of the subcutaneous fat, usually presents with inflammatory nodules. Erythema nodosum (EN) is clinically the most frequent form of panniculitis. Whilst up to 55% of EN is considered idiopathic, the most common causes include infections, drugs, systemic illnesses such as sarcoidosis and inflammatory bowel disease, pregnancy, and malignancy. EN typically presents in the teens and 20s, and is seen more commonly in females. It is often preceded by a non-specific prodrome of one to three weeks, which may include fever, malaise, and symptoms of an upper respiratory tract infection. Cutaneous lesions then follow, typically localized on the extensor aspect of the limbs. The lesions are painful rounded or oval, slightly raised, non-ulcerative red nodules. The exact pathogenesis of EN is not understood, although is thought to result from deposition of immune complexes in the venules of the septae in subcutaneous fat, causing a neutrophilic panniculitis. Even without specific therapy for a causative condition, EN resolves without treatment in most cases.