ተጨማሪ መረጃ ― አማርኛ

Squamous cell carcinoma (SCC) በዩናይትድ ስቴትስ ውስጥ ከ basal cell carcinoma ቀጥሎ በጣም የተለመደ የቆዳ ካንሰር ነው። ብዙውን ጊዜ የሚጀምረው actinic keratosis የተባለች ቅድመ ካንሰር በሽታ ሲሆን፣ ወደ ሌሎች የሰውነት ክፍሎችም ሊሰራጭ ይችላል። ዋናው ምክንያት ከፀሐይ የሚመጣውን አልትራቫዮሌት (UV) ጨረር መጋለጥ ነው፤ ይህም በጊዜ ውስጥ ይከማችል። ሕክምናው ብዙውን ጊዜ በቀዶ ጥገና (ለምሳሌ በጭንቅላቱ እና በአንገት ላይ ያለው SCC) ይደረጋል። የጨረር ሕክምና ለተገደሉ በሽተኞች ወይም ቀዶ ጥገና ማድረግ የማይችሉ ሰዎች አማራጭ ነው። የበሽታ መከላከያ መድሃኒቶች የ SCC አደጋን ይጨምራሉ። ምንም እንኳን እምብዛም ባይሆንም፣ SCC በተለይም በተደረገ የበሽታ መከላከያ ስርአቶች ውስጥ ሊሰራጭ ይችላል። ስለዚህ፣ መደበኛ ምርመራ እና የፀሐይ መከላከያ ኤስ. ሲ. ሲ ለሚያስፈልጉት አስፈላጊ ነው።
Squamous cell carcinoma of the skin or cutaneous squamous cell carcinoma is the second most common form of skin cancer in the United States, behind basal cell carcinoma. Squamous cell carcinoma has precursor lesions called actinic keratosis, exhibits tumor progression and has the potential to metastasize in the body. Ultraviolet (UV) solar radiation is the primary risk factor in the development of cutaneous squamous cell carcinoma and the cumulative exposure received over a lifetime plays a major part in the development of this cancer. Surgical excision is the primary treatment modality for cutaneous squamous cell carcinoma, with Mohs micrographic surgery being the preferred excisional technique for squamous cell carcinoma of the head and neck, and in other areas of high risk or squamous cell carcinoma with high-risk characteristics. Radiation therapy is reserved for squamous cell carcinoma in older patients or those who will not tolerate surgery, or when it has not been possible to obtain clear margins surgically. Adjuvant radiotherapy is commonly after surgical treatment in very high tumors. Immunosuppression significantly increases the risk of squamous cell carcinoma over the course of an individual’s life. Metastasis is uncommon for squamous cell carcinomas arising in areas of chronic sun exposure, but it can take place, and the risk is increased in immunosuppressed patients. Patients with cutaneous squamous cell carcinoma should be examined regularly and remember to use measures to protect from UV damage.

Cutaneous squamous cell carcinoma (CSCC) በሰዎች ላይ በጣም የተለመደ የካንሰር በሽታ ነው፣ ቁጥራቸውም በመጨመር ላይ ነው። ምንም እንኳን CSCC ብዙውን ጊዜ ጥሩ ክሊኒካዊ ባህሪ ያሳየም፣ ነገርግን በአካባቢው ወይም ወደ ሌሎች የሰውነት ክፍሎች ሊሰራጭ ይችላል። የሳይንስ ሊቀመናዎች CSCC እድገት ላይ ተለያዩ መንገዶችን ለይተው አውቀዋል፤ ይህም አዲስ ሕክምናዎችን ለመምጣት ይወስዳል። ከፍተኛ የሚውትሽን እና የበሽታ መከላከያ ክሊኒካዊ ሁኔታዎች በተለይም በሽተኞችን የበሽታ መከላከያ ህክምና እንዲፈጥሩ ያደርጋል። ይህ ግምገማ CSCC (Cutaneous squamous cell carcinoma) የጄኔቲክ ሥርዓቶችን እና የተወሰኑ ሞለኪውሎችን ተገቢ በሚያደርጉ የቅርብ ጊዜ ሕክምናዎችን ይገልጻል።
Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans and its incidence continues to rise. Although CSCC usually display a benign clinical behavior, it can be both locally invasive and metastatic. The signaling pathways involved in CSCC development have given rise to targetable molecules in recent decades. In addition, the high mutational burden and increased risk of CSCC in patients under immunosuppression were part of the rationale for developing the immunotherapy for CSCC that has changed the therapeutic landscape. This review focuses on the molecular basis of CSCC and the current biology-based approaches of targeted therapies and immune checkpoint inhibitors