Toxic epidermal necrosis
☆ እ.ኤ.አ. በ 2022 ከጀርመን የስቲፍቱንግ ዋረንቴስት ውጤቶች ፣ በሞዴልደርም የተገልጋዮች እርካታ ከሚከፈልባቸው የቴሌሜዲኬን ምክሮች በትንሹ ያነሰ ነበር።
የToxic epidermal necrosis የቆዳ መጥፋት ባህሪይ
References
Stevens-Johnson Syndrome (SJS) እና Toxic Epidermal Necrolysis (TEN) የቆዳ መጠነ ሰፊ የሆነ ኒክሮሲስ እና መፍሰስ የሚያጋጥመው ብርቅዬ ሁኔታዎች ናቸው። በሕክምናው ረገድ ሳይክሎፖሪን ለ SJS በጣም ውጤታማ ነው, በደም ውስጥ ያለው ኢሚውኖግሎቡሊን (IVIg) እና corticosteroids ጥምረት ለ SJS እና TEN ጉዳዮች በጣም ጥሩ ነው.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Toxic epidermal necrolysis (TEN) በአንዳንድ መድሀኒቶች እና የበሽታ መከላከል ስርአቶች እንቅስቃሴ የሚፈጠር ከባድ የቆዳ ምላሽ ሲሆን ይህም የውጭውን የቆዳ ሽፋን (epidermis) በከፍተኛ መጠን መነጠል እና ከ30% በላይ የሰውነትን የገጽታ ክፍል ይጎዳል። TEN ከ 20% በላይ የሞት መጠን አለው, ብዙ ጊዜ በኢንፌክሽን እና በአተነፋፈስ ችግር ምክንያት. ምላሹን የሚያስከትል መድሃኒት ማቆም, ድጋፍ ሰጪ እንክብካቤን መስጠት እና ተጨማሪ ህክምናዎችን መጠቀም ውጤቱን ሊያሻሽል ይችላል. በቅርብ ጊዜ የተደረጉ ጥናቶች እንዳመለከቱት በዘፈቀደ ቁጥጥር የተደረገባቸው ሙከራዎች እና የበርካታ ጥናቶች ትንታኔዎች ላይ በመመርኮዝ እንደ ሳይክሎፖሪን፣ እጢ ኒክሮሲስ ፋክተር አልፋ አጋቾች እና የደም ስር መከላከያ ግሎቡሊን እና ኮርቲኮስትሮይድ ያሉ መድኃኒቶች አጋዥ ሊሆኑ ይችላሉ።
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Recent Advances: There is improved understanding of pain and morbidity with regard to the type and frequency of dressing changes. More modern dressings, such as nanocrystalline, are currently favored as they may be kept in situ for longer periods. The most recent evidence on systemic agents, such as corticosteroids and cyclosporine, and novel treatments, are also discussed.
በጣም የተለመደው መንስኤ እንደ ላሞትሪጅን, ካርባማዜፔን, አሎፑሪን, ሰልፎናሚድ አንቲባዮቲክስ እና ኔቪራፒን የመሳሰሉ አንዳንድ መድሃኒቶች ናቸው. የአደጋ መንስኤዎች ኤችአይቪ እና የስርዓት ሉፐስ ኤራይቲማቶሰስን ያካትታሉ. ሕክምናው በተለምዶ በሆስፒታል ውስጥ ለምሳሌ በተቃጠለ ክፍል ውስጥ ወይም ከፍተኛ እንክብካቤ ክፍል ውስጥ ይካሄዳል.
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አጠራጣሪ መድሃኒቶች መቋረጥ አለባቸው. (ለምሳሌ አንቲባዮቲክስ፣ ስቴሮይድ ያልሆኑ ፀረ-ብግነት መድኃኒቶች)