Urticaria pigmentosa
Urticaria pigmentosa በጣም የተለመደ የቆዳ ማስትቶሴሲስ አይነት ነው። በቆዳው ውስጥ ባሉ የጡት ህዋሶች ብዛት የሚከሰት ብርቅዬ በሽታ ሲሆን ይህም በሚበሳጭበት ጊዜ በቆዳ ላይ ቀፎዎችን ወይም ጉዳቶችን ይፈጥራል። ብዙውን ጊዜ ቀይ ወይም ቡናማ ነጠብጣቦች በቆዳ ላይ, በተለይም በደረት, በግንባር እና በጀርባ አካባቢ ይታያሉ. እነዚህ ማስት ሴሎች ሲበሳጩ (ለምሳሌ ቆዳን በማሸት፣ በሙቀት መጋለጥ) በጣም ብዙ ሂስታሚን ያመነጫሉ፣ ይህም ወደ ብስጭት አካባቢ ወደሚገኙ ቀፎዎች የሚያመራውን የአለርጂ ምላሹን ያስነሳል፣ አንዳንዴም “ዳሪየር ምልክት” ይባላል።
☆ እ.ኤ.አ. በ 2022 ከጀርመን የስቲፍቱንግ ዋረንቴስት ውጤቶች ፣ በሞዴልደርም የተገልጋዮች እርካታ ከሚከፈልባቸው የቴሌሜዲኬን ምክሮች በትንሹ ያነሰ ነበር።
References
Mastocytosis የተትረፈረፈ የማስት ሴሎች ያሉበት ሁኔታ ነው፣ ብዙ ጊዜ በተለያዩ የሰውነት ክፍሎች እንደ ቆዳ፣ መቅኒ እና የምግብ መፈጨት ሥርዓት ይገኛሉ። እንደ የዓለም ጤና ድርጅት (WHO) cutaneous mastocytosis በሦስት ዋና ዋና ዓይነቶች ሊከፈል ይችላል። የመጀመሪያው ዓይነት (mastocytomas) ብቸኛ ወይም ጥቂት (≤3) ጉዳቶችን ያካትታል። ሁለተኛው ዓይነት (urticaria pigmentosa) ብዙ ቁስሎችን ያጠቃልላል፣ በተለይም ከ10 እስከ 100 ያነሱ ናቸው። Urticaria pigmentosa በልጆች ላይ በጣም የተለመደ የቆዳ በሽታ ማስትቶሲስ ዓይነት ነው፣ ነገር ግን በአዋቂዎች ላይም ሊከሰት ይችላል። ብዙውን ጊዜ በጉርምስና ወቅት የሚሻሻል ምንም ጉዳት የሌለው ሁኔታ ነው። እንደ ትልቅ ሰው ማስቶሲቶሲስ፣ urticaria pigmentosa የውስጥ አካላትን ብዙም አይጎዳም። የ urticaria pigmentosa አንድ ልዩ ባህሪ በቆዳው ላይ ትናንሽ ፣ ማሳከክ ፣ ቀይ-ቡናማ ፣ ወይም ቢጫ-ቡናማ ነጠብጣቦችን ወይም ጉዳቶችን የመፍጠር ዝንባሌው ነው ፣በተለምዶ ቀፎ በመባል ይታወቃል። እነዚህ ነጠብጣቦች ብዙውን ጊዜ በልጅነት ውስጥ ይታያሉ እና በሕይወት ዘመናቸው ሁሉ ሊቆዩ ይችላሉ።
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
አንዲት የ6 አመት ልጅ መጀመሪያ በጭንቅላቷ ላይ የታዩ እና ባለፉት ስድስት ወራት ውስጥ ወደ ፊቷ እና ሰውነቷ የተዛመቱ በርካታ ጥቁር ቀለም ያላቸው ነጠብጣቦች ይዛ መጣች። ግፊት ሲደረግባቸው ሲነሱ፣ ቀይ ሲለወጡ እና ማሳከክ እንደተሰማት ተናግራለች። ማጠብ፣ ማስታወክ፣ ተቅማጥ ወይም የትንፋሽ ጩኸት አላጋጠማትም፣ እና የግል እና የቤተሰብ የህክምና ታሪኮቿ ተዛማጅ ፍንጮችን አልሰጡም። በምርመራ ወቅት፣ በደረቷ እና በጀርባዋ ላይ ትንሽ ከፍ ያሉ ጥቁር ነጠብጣቦች በጭንቅላቷ፣ በግንባሯ፣ ፊት እና አንገቷ ላይ ብዙ ጥቁር ነጠብጣቦችን አግኝተናል። ነጥቦቹን በትንሹ ማሸት በ 2 ደቂቃ ውስጥ እብጠት እና ማሳከክ ምክንያት ሆኗል, ነገር ግን ምልክቶቹ ከ15-20 ደቂቃዎች (Darier's sign) ውስጥ ደብዝዘዋል.
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
