ተጨማሪ መረጃ ― አማርኛ

Urticarial vasculitis ለረጅም ጊዜ የሚቆይ ወይም በተደጋጋሚ በሚከሰት የቀፎ በሽታ ተለይቶ የሚታይ ያልተለመደ በሽታ ነው። የቆዳ ምልክቶቹ ሥር የሰደደ ቀፎዎችን ሊመስሉ ቢችሉም, ልዩ ናቸው ምክንያቱም ቀፎዎቹ ቢያንስ ለ 24 ሰዓታት ስለሚቆዩ እና ከደበዘዙ በኋላ ጥቁር ነጠብጣቦችን ሊያስከትሉ ስለሚችሉ ነው. ምንም እንኳን ምክንያቱ ብዙ ጊዜ ባይታወቅም, አንዳንድ ጊዜ በአንዳንድ መድሃኒቶች, ኢንፌክሽኖች, ራስን በራስ የሚከላከሉ በሽታዎች, የደም እክሎች ወይም ካንሰሮች ሊነሳ ይችላል. አንዳንድ ጥናቶች ከኮቪድ-19 እና ከH1N1 ፍሉ ጋር ያገናኙታል። እንደ ጡንቻ፣ ኩላሊት፣ ሳንባ፣ ሆድ እና አይን ያሉ የሰውነት ክፍሎችን ሊጎዳ ይችላል። አንድ ዓይነት የቲሹ ምርመራ ምርመራውን ሊያረጋግጥ ቢችልም ሁልጊዜ አስፈላጊ አይደለም. ሕክምናው ብዙውን ጊዜ በፀረ-ባክቴሪያዎች፣ ዳፕሶን፣ ኮልቺሲን ወይም ሃይድሮክሲክሎሮኩዊን ይጀምራል። ለበለጠ ከባድ ጉዳዮች፣ እንደ ሜቶቴሬክሲት ወይም ኮርቲሲቶይድ ያሉ የሰውነትን በሽታ የመከላከል ስርዓትን የሚገቱ መድኃኒቶች ያስፈልጉ ይሆናል። በቅርብ ጊዜ, ባዮሎጂካል ሕክምናዎች (rituximab, omalizumab, interleukin-1 inhibitors) ለጠንካራ ጉዳዮች ተስፋን አሳይተዋል.
Urticarial vasculitis is a rare clinicopathologic entity that is characterized by chronic or recurrent episodes of urticarial lesions. Skin findings of this disease can be difficult to distinguish visually from those of chronic idiopathic urticaria but are unique in that individual lesions persist for ≥24 hours and can leave behind dusky hyperpigmentation. This disease is most often idiopathic but has been linked to certain drugs, infections, autoimmune connective disease, myelodysplastic disorders, and malignancies. More recently, some authors have reported associations between urticarial vasculitis and COVID-19, as well as influenza A/H1N1 infection. Urticarial vasculitis can extend systemically as well, most often affecting the musculoskeletal, renal, pulmonary, gastrointestinal, and ocular systems. Features of leukocytoclastic vasculitis seen on histopathologic examination are diagnostic of this disease, but not always seen. In practice, antibiotics, dapsone, colchicine, and hydroxychloroquine are popular first-line therapies, especially for mild cutaneous disease. In more severe cases, immunosuppressives, including methotrexate, mycophenolate mofetil, azathioprine, and cyclosporine, as well as corticosteroids, may be necessary for control. More recently, select biologic therapies, including rituximab, omalizumab, and interleukin-1 inhibitors have shown promise for the treatment of recalcitrant or refractory cases.

የ35 አመቱ ሰው የ15 ቀን ታሪኩ በደማቅ ቀይ ፣ በሁለቱም ጭኑ እና እግሮቹ ላይ የሚያም ሽፍታ ፣ ከመገጣጠሚያ ህመም ጋር አብሮ ገባ። ሽፍታው ከመታየቱ በፊት ለአንድ ሳምንት ያህል የሽንት ቱቦ ኢንፌክሽን ነበረው. ቆዳው በጭኑና በእግሮቹ በሁለቱም በኩል ብዙ ለስላሳ፣ የቀለበት ቅርጽ ያላቸው፣ ከፊል ሊገለሉ የሚችሉ፣ ቀይ ንጣፎችን አሳይቷል። እንቅልፍ ከሌለው ፀረ-ሂስታሚን (fexofenadine) ጋር ለአንድ ሳምንት ያህል የቃል ፕሬኒሶሎን (40mg / day) ተሰጥቷል. በአንድ ሳምንት ውስጥ ሁሉም ሽፍታዎች ሙሉ በሙሉ ጠፍተዋል. በሚቀጥሉት 6 ወራት መደበኛ ምርመራዎች ምንም ተጨማሪ ሽፍታዎች አልነበሩም።
A 35-year-old man came in with a 15-day history of bright red, painful rashes on both thighs and legs, along with joint pain. He had a urinary tract infection for a week before the rash appeared. His skin showed several tender, ring-shaped, partially blanchable, red plaques on both sides of his thighs and legs. He was given oral prednisolone (40mg/day) for a week along with a non-drowsy antihistamine (fexofenadine). Within a week, all the rashes disappeared completely. There were no more rashes during the next 6 months of regular check-ups.