Erythema nodosum - حمامي عقدية
يظهر على شكل عقدة حمامية مؤلمة على الساق.
References
Erythema nodosum هو النوع الأكثر شيوعًا من التهاب السبلة الشحمية، ويتميز بوجود عقيدات حمراء مؤلمة، توجد بشكل رئيسي في أسفل الساقين. ولا يزال سببه الدقيق غير معروف، ولكن يبدو أنه ينجم عن استجابة مبالغ فيها لمحفزات مختلفة. على الرغم من أن أصله غير مؤكد في كثير من الأحيان، فمن الضروري استبعاد الحالات الأساسية الأخرى قبل تشخيص primary erythema nodosum. يمكن أن يشير إلى بداية أمراض جهازية مثل العدوى أو الالتهاب أو السرطان أو ردود الفعل تجاه الدواء. تتضمن المشغلات الشائعة strep infections, tuberculosis, sarcoidosis, Behçet's disease, inflammatory bowel disease, certain medications, and pregnancy.
Erythema nodosum is the most common form of panniculitis and is characterized by tender erythematous nodules mainly in the lower limbs on the pretibial area. The exact cause of erythema nodosum is unknown, although it appears to be a hypersensitivity response to a variety of antigenic stimuli. Although the etiology is mostly idiopathic, ruling out an underlying disease is imperative before diagnosing primary erythema nodosum. Erythema nodosum can be the first sign of a systemic disease that is triggered by a large group of processes, such as infections, inflammatory diseases, neoplasia, and/or drugs. The most common identifiable causes are streptococcal infections, primary tuberculosis, sarcoidosis, Behçet disease, inflammatory bowel disease, drugs, and pregnancy.
Erythema nodosum is the most common form of panniculitis and is characterized by tender erythematous nodules mainly in the lower limbs on the pretibial area. The exact cause of erythema nodosum is unknown, although it appears to be a hypersensitivity response to a variety of antigenic stimuli. Although the etiology is mostly idiopathic, ruling out an underlying disease is imperative before diagnosing primary erythema nodosum. Erythema nodosum can be the first sign of a systemic disease that is triggered by a large group of processes, such as infections, inflammatory diseases, neoplasia, and/or drugs. The most common identifiable causes are streptococcal infections, primary tuberculosis, sarcoidosis, Behçet disease, inflammatory bowel disease, drugs, and pregnancy.
Panniculitis يشير إلى مجموعة متنوعة من الحالات الالتهابية التي تؤثر على الأنسجة الدهنية تحت الجلد. هذه الحالات غير شائعة عند الأطفال. Panniculitis يمكن أن يكون المشكلة الرئيسية في حالة جهازية أو رد فعل ثانوي لعوامل مثل العدوى أو الإصابة أو بعض الأدوية. بغض النظر عن السبب، تظهر معظم أنواع panniculitis أعراض مشابهة، بما في ذلك عقيدات حمراء مؤلمة تحت الجلد.
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.
Panniculitis ، التهاب الطبقة الدهنية تحت الجلد، وهو حالة نادرة تظهر عادةً على شكل عقيدات أو بقع منتفخة. Erythema nodosum (EN) هو النوع الأكثر شيوعًا، وغالبًا ما يتم تحفيزه بواسطة عوامل مختلفة. في حين أن حوالي 55% من الحالات ليس لها سبب واضح، إلا أن المسببات الشائعة تشمل الالتهابات والأدوية وبعض الأمراض مثل الساركويد ومرض التهاب الأمعاء والحمل والسرطان. يظهر EN عادة عند المراهقين والشباب، وفي كثير من الأحيان عند الإناث. وغالبًا ما يسبقه شعور عام بالمرض يستمر من أسبوع إلى ثلاثة أسابيع، مع أعراض مثل الحمى ومشاكل في الجهاز التنفسي العلوي. ثم تظهر بعد ذلك عقيدات حمراء، عادة على الجوانب الخارجية للذراعين والساقين، مما يسبب الألم. السبب الدقيق لالتهاب القولون التقرحي غير مفهوم تمامًا، ولكن يُعتقد أنه يشمل المجمعات المناعية في الأوعية الدموية الصغيرة في الطبقة الدهنية، مما يؤدي إلى الالتهاب. عادة، تظهر الخزعة التهابًا في الطبقة الدهنية دون الإضرار بالأوعية الدموية. حتى بدون علاج محدد للسبب الأساسي، غالبًا ما يتم حل التهاب الأمعاء من تلقاء نفسه. لذلك، يحتاج معظم المرضى فقط إلى رعاية داعمة لأعراضهم.
Panniculitis, an inflammation of the fat layer under the skin, is a rare condition usually showing up as swollen nodules or patches. Erythema nodosum (EN) is the most common type, often triggered by various factors. While around 55% of cases have no clear cause, common triggers include infections, medications, certain diseases like sarcoidosis and inflammatory bowel disease, pregnancy, and cancer. EN usually appears in teens and young adults, more often in females. It's often preceded by a general feeling of illness lasting one to three weeks, with symptoms like fever and upper respiratory issues. Then, red nodules appear, usually on the outer sides of arms and legs, causing pain. EN's exact cause isn't fully understood, but it's believed to involve immune complexes in small blood vessels of the fat layer, leading to inflammation. Typically, a biopsy shows inflammation in the fat layer without damage to blood vessels. Even without specific treatment for the underlying cause, EN often resolves on its own. So, most patients need only supportive care for their symptoms.
Panniculitis, an inflammation of the fat layer under the skin, is a rare condition usually showing up as swollen nodules or patches. Erythema nodosum (EN) is the most common type, often triggered by various factors. While around 55% of cases have no clear cause, common triggers include infections, medications, certain diseases like sarcoidosis and inflammatory bowel disease, pregnancy, and cancer. EN usually appears in teens and young adults, more often in females. It's often preceded by a general feeling of illness lasting one to three weeks, with symptoms like fever and upper respiratory issues. Then, red nodules appear, usually on the outer sides of arms and legs, causing pain. EN's exact cause isn't fully understood, but it's believed to involve immune complexes in small blood vessels of the fat layer, leading to inflammation. Typically, a biopsy shows inflammation in the fat layer without damage to blood vessels. Even without specific treatment for the underlying cause, EN often resolves on its own. So, most patients need only supportive care for their symptoms.
يتم تشخيص الحمامي العقدية سريريا. يمكن أخذ خزعة وفحصها مجهريا لتأكيد التشخيص غير المؤكد. يجب إجراء تصوير بالأشعة السينية على الصدر لاستبعاد الأمراض الرئوية، وخاصة الساركويد والسل.