Livedoid vasculitis - التهاب الاوعية الشبيه بالترخم
التهاب الاوعية الشبيه بالترخم (Livedoid vasculitis) هو مرض جلدي مزمن يظهر في الغالب عند النساء الشابات إلى منتصف العمر. أحد الاختصارات المستخدمة لوصف ميزاته هو "قرحة برفرية مؤلمة ذات نمط شبكي في الأطراف السفلية" (أرجواني). ويرتبط بعدد من الأمراض، بما في ذلك ارتفاع ضغط الدم الوريدي المزمن والدوالي.
☆ في نتائج Stiftung Warentest لعام 2022 من ألمانيا، كان رضا المستهلكين عن ModelDerm أقل قليلاً مقارنة بالاستشارات الطبية عن بعد المدفوعة.
يمكن أن يصاحبه ألم.
References
Livedoid vasculopathy هي حالة جلدية نادرة تتميز بقرح مؤلمة تعود باستمرار إلى أسفل الساقين.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy هي حالة جلدية نادرة تسبب تقرحات متكررة في أسفل الساقين، تاركة وراءها ندبات شاحبة تعرف باسم ضمور بلانش. في حين أن السبب الدقيق لا يزال غير واضح، فمن المعتقد أن زيادة تخثر الدم (hypercoagulability) هو العامل الرئيسي، حيث يلعب الالتهاب دورًا ثانويًا. العوامل المساهمة في التجلط تشمل ما يلي - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. في الخزعات، تظهر الحالة جلطات دموية داخل الأوعية، وسماكة جدران الأوعية الدموية، والتندب. يتضمن العلاج نهجًا متعدد الجوانب يركز على منع تجلط الدم باستخدام أدوية مثل الأدوية المضادة للصفائح الدموية، ومخففات الدم، والعلاج الحال للفيبرين. يمكن استخدام أدوية مختلفة لهذه الحالة الجلدية - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy هي حالة نادرة تحدث فيها آفات في كلا الساقين. يُعتقد أن تكون جلطات الدم في الأوعية الدموية الصغيرة يحدث بسبب زيادة التخثر وانخفاض تحلل الجلطات، إلى جانب تلف بطانة الأوعية الدموية. وهو أكثر شيوعًا عند الإناث، خاصة بين سن 15 و50 عامًا. وقد كان الإقلاع عن التدخين والعناية بالجروح واستخدام الأدوية مثل مميعات الدم والأدوية المضادة للصفيحات فعالاً.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
