Livedoid vasculitis - Livedoid Vaskulit
Livedoid Vaskulit (Livedoid vasculitis) əsasən gənc və orta yaşlı qadınlarda müşahidə olunan xroniki dəri xəstəliyidir. Onun xüsusiyyətlərini təsvir etmək üçün istifadə edilən qısaltmalardan biri "Aşağı ətrafların retikulyar naxışlı ağrılı purpurik xoralar"dır (BƏNƏNİŞİ). Xroniki venoz hipertoniya və varikozlar da daxil olmaqla bir sıra xəstəliklərlə əlaqələndirilir.
☆ Almaniyadan olan 2022 Stiftung Warentest nəticələrinə görə, ModelDerm-dən istehlakçı məmnunluğu pullu teletibb məsləhətləşmələrindən bir qədər aşağı idi.
Ağrı ilə müşayiət oluna bilər.
References
Livedoid vasculopathy ayaqların alt hissəsində təkrarlanan ağrılı xoralarla xarakterizə edilən nadir bir dəri xəstəliyidir.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy , aşağı ayaqlarda təkrarlanan xoralara səbəb olan, atrofi blanş kimi tanınan solğun çapıqlar buraxan nadir bir dəri xəstəliyidir. Dəqiq səbəb hələ də bəlli olmasa da, qan laxtalanmasının artmasının (hypercoagulability) əsas amil olduğuna inanılır, iltihab isə ikinci dərəcəli rol oynayır. Laxtalanmaya kömək edən amillərə aşağıdakılar daxildir - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. Biyopsilərdə vəziyyət damarların içərisində qan laxtalanmasını, damar divarlarının qalınlaşması və çapıqları göstərir. Müalicə antitrombosit dərmanlar, qan durulaşdırıcılar və fibrinolitik terapiya kimi dərmanlarla qan laxtalanmasının qarşısını almağa yönəlmiş çox yönlü yanaşmanı əhatə edir. Bu dəri vəziyyəti üçün müxtəlif dərmanlar istifadə edilə bilər - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy hər iki ayaqda lezyonların meydana gəldiyi nadir bir vəziyyətdir. Kiçik qan damarlarında qan laxtalarının əmələ gəlməsinin damar selikli qişasının zədələnməsi ilə yanaşı, laxtalanmanın artması və laxtalanmanın azalması nəticəsində meydana gəldiyi düşünülür. Xüsusilə 15-50 yaş arası qadınlarda daha çox rast gəlinir. Siqareti tərgitmək, yaralara qulluq etmək, qan durulaşdırıcı və antiplatelet dərmanları kimi dərmanlardan istifadə etmək təsirli olmuşdur.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
