Porokeratosis - Порокератоз
☆ У выніках Stiftung Warentest у Германіі ў 2022 годзе задаволенасць спажыўцоў ModelDerm была толькі крыху ніжэйшай, чым платнымі тэлемедыцынскімі кансультацыямі.
Характэрныя жорсткія выступоўцы краю.
References
Porokeratosis - гэта рэдкае захворванне скуры, якое характарызуецца праблемамі арагавенне, у выніку чаго на скуры з'яўляюцца прыпаднятыя колцападобныя ўчасткі або грубыя няроўнасці. Яе вызначальнай асаблівасцю пад мікраскопам з'яўляецца наяўнасць корноіднай пласцінкі, асаблівага размяшчэння клетак у верхнім пласце скуры. Porokeratosis бывае розных формаў (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis) . Важна адзначыць, што porokeratosis патэнцыйна можа перарасці ў рак скуры. Лепшы спосаб дыягнаставання porokeratosis - гэта біяпсія прыпаднятай мяжы, хоць у цяперашні час не існуе стандартнага пратаколу лячэння.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) - хвароба парушэння арагавенне. Гэта адзін з шасці тыпаў порокератоза, і ён звычайна дзівіць большыя плошчы ў параўнанні з іншымі (linear, Mibelli's, punctate, palmoplantar disseminated, superficial porokeratosis) . Эруптивный тып порокератоза часта звязаны з ракам, аслабленым імунітэтам або запаленнем. Фактары рызыкі ўключаюць генетыку, падаўленне імунітэту і ўздзеянне сонца. DSAP пачынаецца з ружовых або карычневых гузоў з прыпаднятымі бакамі ў адкрытых для сонца месцах, якія часам выклікаюць лёгкі сверб. Метады лячэння адрозніваюцца і могуць уключаць мясцовыя крэмы, светлавую тэрапію або такія лекі, як 5-фторурацыл або рэтыноіды. Гэтыя паразы лічацца предраковыми з 7. 5 - 10 % верагоднасцю пераўтварэння ў плоскоклеточный або базаліёма.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
52-гадовы мужчына, раней здаровы, звярнуўся з плоскай кольцападобнай плямай на канцы чацвёртага пальца ногі, якая была там на працягу 2 гадоў, не выклікаючы ніякіх сімптомаў. Гэта пачалося як невялікая, цвёрдая шышка і з часам вырасла вонкі. Нягледзячы на спробы розных метадаў лячэння, такіх як крыятэрапія, крэмы, супрацьгрыбковыя сродкі і антыбіётыкі, пластыр не стаў лепш. Уважлівае даследаванне з дапамогай дэрмакопіі паказала сухі чырвоны цэнтр з тоўстай шурпатай аблямоўкай. Малюсенькі кавалачак скуры, узяты з краю пластыру, паказаў ненармальны рост клетак у вонкавым пласце скуры, што пацвярджае дыягназ porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
Часта праводзіцца біяпсія, таму што яна можа выглядаць падобна на актинический кератоз або плоскоклеточный рак.