Livedoid vasculitis - Livedoid Васкулит
Livedoid Васкулит (Livedoid vasculitis) е хронично кожно заболяване, наблюдавано предимно при жени на млада до средна възраст. Един акроним, използван за описване на характеристиките му, е „Болезнени пурпурни язви с ретикуларен модел на долните крайници“ (ЛИЛАВО). Свързва се с редица заболявания, включително хронична венозна хипертония и разширени вени.
☆ В резултатите от Stiftung Warentest за 2022 г. в Германия, потребителското удовлетворение от ModelDerm е само малко по-ниско, отколкото при платените телемедицински консултации.
Може да бъде придружено от болка.
References
Livedoid vasculopathy е рядко кожно заболяване, характеризиращо се с болезнени язви, които постоянно се появяват на долната част на краката.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy е рядко кожно заболяване, което причинява повтарящи се язви на долната част на краката, оставяйки след себе си бледи белези, известни като atrophie blanche. Въпреки че точната причина все още не е ясна, смята се, че повишеното съсирване на кръвта (hypercoagulability) е основният фактор, като възпалението играе второстепенна роля. Факторите, допринасящи за съсирването, включват следното - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. При биопсии състоянието показва кръвни съсиреци вътре в съдовете, удебеляване на съдовите стени и белези. Лечението включва многостранен подход, фокусиран върху предотвратяването на кръвни съсиреци с лекарства като антитромбоцитни лекарства, разредители на кръвта и фибринолитична терапия. За това състояние на кожата могат да се използват различни лекарства - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy е рядко състояние, при което се появяват лезии и на двата крака. Смята се, че образуването на кръвни съсиреци в малки кръвоносни съдове се причинява от повишено съсирване и намалено разграждане на съсирека, заедно с увреждане на лигавицата на съдовете. По-често се среща при жени, особено на възраст между 15 и 50 години. Спирането на тютюнопушенето, грижата за рани и употребата на лекарства като разредители на кръвта и антиагреганти са ефективни.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
