Squamous cell carcinoma - Плоскоклетъчен Карцином
☆ В резултатите от Stiftung Warentest за 2022 г. в Германия, потребителското удовлетворение от ModelDerm е само малко по-ниско, отколкото при платените телемедицински консултации.
Squamous cell carcinoma well differentiated ― Наблюдава се съседна актинична кератоза.
References
Squamous cell carcinoma (SCC) е вторият най-често срещан рак на кожата в Съединените щати след basal cell carcinoma. Обикновено започва от предракови лезии, наречени actinic keratosis , и може да се разпространи в други части на тялото. Основната причина е излагането на ултравиолетова (UV) радиация от слънцето, която се натрупва с течение на времето. Лечението обикновено включва хирургично отстраняване, особено за SCC на главата и шията. Лъчевата терапия е опция за по-възрастни пациенти или тези, които не могат да бъдат оперирани. Имуносупресията повишава риска от SCC. Макар и рядко, SCC може да се разпространи, особено при пациенти с отслабена имунна система. Редовните прегледи и слънцезащитата са важни за тези със SCC.
Squamous cell carcinoma of the skin or cutaneous squamous cell carcinoma is the second most common form of skin cancer in the United States, behind basal cell carcinoma. Squamous cell carcinoma has precursor lesions called actinic keratosis, exhibits tumor progression and has the potential to metastasize in the body. Ultraviolet (UV) solar radiation is the primary risk factor in the development of cutaneous squamous cell carcinoma and the cumulative exposure received over a lifetime plays a major part in the development of this cancer. Surgical excision is the primary treatment modality for cutaneous squamous cell carcinoma, with Mohs micrographic surgery being the preferred excisional technique for squamous cell carcinoma of the head and neck, and in other areas of high risk or squamous cell carcinoma with high-risk characteristics. Radiation therapy is reserved for squamous cell carcinoma in older patients or those who will not tolerate surgery, or when it has not been possible to obtain clear margins surgically. Adjuvant radiotherapy is commonly after surgical treatment in very high tumors. Immunosuppression significantly increases the risk of squamous cell carcinoma over the course of an individual’s life. Metastasis is uncommon for squamous cell carcinomas arising in areas of chronic sun exposure, but it can take place, and the risk is increased in immunosuppressed patients. Patients with cutaneous squamous cell carcinoma should be examined regularly and remember to use measures to protect from UV damage.
Squamous cell carcinoma of the skin or cutaneous squamous cell carcinoma is the second most common form of skin cancer in the United States, behind basal cell carcinoma. Squamous cell carcinoma has precursor lesions called actinic keratosis, exhibits tumor progression and has the potential to metastasize in the body. Ultraviolet (UV) solar radiation is the primary risk factor in the development of cutaneous squamous cell carcinoma and the cumulative exposure received over a lifetime plays a major part in the development of this cancer. Surgical excision is the primary treatment modality for cutaneous squamous cell carcinoma, with Mohs micrographic surgery being the preferred excisional technique for squamous cell carcinoma of the head and neck, and in other areas of high risk or squamous cell carcinoma with high-risk characteristics. Radiation therapy is reserved for squamous cell carcinoma in older patients or those who will not tolerate surgery, or when it has not been possible to obtain clear margins surgically. Adjuvant radiotherapy is commonly after surgical treatment in very high tumors. Immunosuppression significantly increases the risk of squamous cell carcinoma over the course of an individual’s life. Metastasis is uncommon for squamous cell carcinomas arising in areas of chronic sun exposure, but it can take place, and the risk is increased in immunosuppressed patients. Patients with cutaneous squamous cell carcinoma should be examined regularly and remember to use measures to protect from UV damage.
Cutaneous squamous cell carcinoma (CSCC) е вторият най-разпространен рак при хората и броят му нараства. Въпреки че CSCC обикновено показва доброкачествено клинично поведение, той може да се разпространи както локално, така и в други части на тялото. Учените са идентифицирали специфични пътища, включени в развитието на CSCC, което води до нови лечения. Големият брой мутации и повишеният риск при пациенти с имуносупресия подтикнаха развитието на имунотерапията. Този преглед разглежда генетичните корени на CSCC и най-новите лечения, насочени към специфични молекули и имунната система.
Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans and its incidence continues to rise. Although CSCC usually display a benign clinical behavior, it can be both locally invasive and metastatic. The signaling pathways involved in CSCC development have given rise to targetable molecules in recent decades. In addition, the high mutational burden and increased risk of CSCC in patients under immunosuppression were part of the rationale for developing the immunotherapy for CSCC that has changed the therapeutic landscape. This review focuses on the molecular basis of CSCC and the current biology-based approaches of targeted therapies and immune checkpoint inhibitors
Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans and its incidence continues to rise. Although CSCC usually display a benign clinical behavior, it can be both locally invasive and metastatic. The signaling pathways involved in CSCC development have given rise to targetable molecules in recent decades. In addition, the high mutational burden and increased risk of CSCC in patients under immunosuppression were part of the rationale for developing the immunotherapy for CSCC that has changed the therapeutic landscape. This review focuses on the molecular basis of CSCC and the current biology-based approaches of targeted therapies and immune checkpoint inhibitors
○ Диагностика и лечение
#Dermoscopy
#Skin biopsy