Acne - Akne
☆ U rezultatima Stiftung Warentest-a za 2022. iz Njemačke, zadovoljstvo potrošača ModelDerm-om bilo je samo nešto niže nego s plaćenim telemedicinskim konsultacijama.
Akne u predjelu torza. Gornji dio trupa i leđa su uobičajena područja akni.
References
Akne, najčešće stanje kože u Sjedinjenim Državama, su uporni upalni problem kože. Tretman ima za cilj rješavanje četiri glavna faktora koji doprinose nastanku akni: prekomjerna proizvodnja sebuma, nakupljanje ćelija kože, kolonizacija Propionibacterium acnes i rezultirajuća upala. Lokalni retinoidi efikasno upravljaju upalnim i neupalnim lezijama tako što sprečavaju i smanjuju komedone dok se bave upalom. Benzoil peroksid, dostupan u slobodnoj prodaji, je baktericidni agens koji ne potiče otpornost bakterija. Dok lokalni i oralni antibiotici djeluju sami, njihova kombinacija s lokalnim retinoidima povećava njihovu učinkovitost. Dodavanje benzoil peroksida antibiotskoj terapiji smanjuje rizik od rezistencije bakterija. Oralni izotretinoin, odobren za teške i tvrdokorne akne, primjenjuje se kroz iPLEDGE program.
Acne, the most common skin condition in the United States, is a persistent inflammatory skin problem. Treatment aims at addressing four main factors contributing to acne: excessive sebum production, skin cell buildup, Propionibacterium acnes colonization, and resulting inflammation. Topical retinoids effectively manage both inflammatory and non-inflammatory lesions by preventing and reducing comedones while addressing inflammation. Benzoyl peroxide, available over-the-counter, is a bactericidal agent without promoting bacterial resistance. While topical and oral antibiotics work alone, combining them with topical retinoids enhances their effectiveness. Adding benzoyl peroxide to antibiotic therapy lowers the risk of bacterial resistance. Oral isotretinoin, approved for severe and stubborn acne, is administered through the iPLEDGE program.
Acne, the most common skin condition in the United States, is a persistent inflammatory skin problem. Treatment aims at addressing four main factors contributing to acne: excessive sebum production, skin cell buildup, Propionibacterium acnes colonization, and resulting inflammation. Topical retinoids effectively manage both inflammatory and non-inflammatory lesions by preventing and reducing comedones while addressing inflammation. Benzoyl peroxide, available over-the-counter, is a bactericidal agent without promoting bacterial resistance. While topical and oral antibiotics work alone, combining them with topical retinoids enhances their effectiveness. Adding benzoyl peroxide to antibiotic therapy lowers the risk of bacterial resistance. Oral isotretinoin, approved for severe and stubborn acne, is administered through the iPLEDGE program.
Uobičajeni lokalni tretmani za akne uključuju benzoyl peroxide (BP) , salicylic acid, antibiotics, combinations of antibiotics with BP, retinoids, combinations of retinoids with BP or antibiotics, azelaic acid, and sulfone agents. Oralni antibiotici su dugo bili ključni dio liječenja akni, posebno za umjerene do teške slučajeve. Oni najbolje djeluju kada se koriste zajedno s lokalnim retinoidom i krvnim tlakom. Tetracycline, doxycycline, minocycline, trimethoprim/sulfamethoxazole (TMP/SMX) , trimethoprim, erythromycin, azithromycin, amoxicillin, and cephalexin su svi pokazali dokaze efikasnosti.
Common topical treatments for acne include benzoyl peroxide (BP), salicylic acid, antibiotics, combinations of antibiotics with BP, retinoids, combinations of retinoids with BP or antibiotics, azelaic acid, sulfone agents. Oral antibiotics have long been a key part of acne treatment, especially for moderate to severe cases. They work best when used alongside a topical retinoid and BP. Tetracycline, doxycycline, minocycline, trimethoprim/sulfamethoxazole (TMP/SMX), trimethoprim, erythromycin, azithromycin, amoxicillin, cephalexin have all shown evidence of effectiveness.
Common topical treatments for acne include benzoyl peroxide (BP), salicylic acid, antibiotics, combinations of antibiotics with BP, retinoids, combinations of retinoids with BP or antibiotics, azelaic acid, sulfone agents. Oral antibiotics have long been a key part of acne treatment, especially for moderate to severe cases. They work best when used alongside a topical retinoid and BP. Tetracycline, doxycycline, minocycline, trimethoprim/sulfamethoxazole (TMP/SMX), trimethoprim, erythromycin, azithromycin, amoxicillin, cephalexin have all shown evidence of effectiveness.
Lokalni retinoidi se uvijek preporučuju za liječenje akni. Kada koristite sistemske ili lokalne antibiotike, važno je da ih kombinujete sa benzoil peroksidom i retinoidima, ali samo do 12 nedelja. Isotretinoin je rezervisan za teške slučajeve akni koje nisu reagovale na druge tretmane. Iako postoje dokazi za fizikalne tretmane kao što su laserska terapija i hemijski piling, kao i komplementarni pristupi kao što su pročišćeni pčelinji otrov i određene dijete, njihova efikasnost je još uvijek neizvjesna.
Topical retinoids are always recommended for treating acne. When using systemic or topical antibiotics, it's important to combine them with benzoyl peroxide and retinoids, but only for up to 12 weeks. Isotretinoin is reserved for severe cases of acne that haven't responded to other treatments. While there's some evidence for physical treatments like laser therapy and chemical peels, as well as complementary approaches such as purified bee venom and certain diets, their effectiveness is still uncertain.
Topical retinoids are always recommended for treating acne. When using systemic or topical antibiotics, it's important to combine them with benzoyl peroxide and retinoids, but only for up to 12 weeks. Isotretinoin is reserved for severe cases of acne that haven't responded to other treatments. While there's some evidence for physical treatments like laser therapy and chemical peels, as well as complementary approaches such as purified bee venom and certain diets, their effectiveness is still uncertain.
Nekoliko studija je proučavalo kako različita hrana utiče na akne kod pacijenata. Otkrili su da ljudi sa aknama koji jedu hranu sa niskim glikemijskim opterećenjem imaju manje mrlja od akni u poređenju sa onima koji jedu hranu sa visokim glikemijskim opterećenjem. Mliječni proizvodi su također proučavani u vezi s aknama. Čini se da određeni proteini u mlijeku mogu više doprinijeti nastanku akni od masti ili ukupnog sadržaja mliječnih proizvoda. Druga istraživanja su se fokusirala na omega-3 masne kiseline i γ-linolnu kiselinu. To sugerira da bi ljudi s aknama mogli imati koristi od jedenja više ribe i zdravih ulja kako bi povećali unos ovih masnih kiselina. Nedavne studije o probioticima za akne pokazuju obećavajuće rezultate, ali je potrebno više istraživanja kako bi se potvrdili ovi rani nalazi.
Several studies have evaluated the significance of the glycemic index of various foods and glycemic load in patients with acne, demonstrating individuals with acne who consume diets with a low glycemic load have reduced acne lesions compared with individuals on high glycemic load diets. Dairy has also been a focus of study regarding dietary influences on acne; whey proteins responsible for the insulinotropic effects of milk may contribute more to acne development than the actual fat or dairy content. Other studies have examined the effects of omega-3 fatty acid and γ-linoleic acid consumption in individuals with acne, showing individuals with acne benefit from diets consisting of fish and healthy oils, thereby increasing omega-3 and omega-6 fatty acid intake. Recent research into the effects of probiotic administration in individuals with acne present promising results; further study of the effects of probiotics on acne is needed to support the findings of these early studies.
Several studies have evaluated the significance of the glycemic index of various foods and glycemic load in patients with acne, demonstrating individuals with acne who consume diets with a low glycemic load have reduced acne lesions compared with individuals on high glycemic load diets. Dairy has also been a focus of study regarding dietary influences on acne; whey proteins responsible for the insulinotropic effects of milk may contribute more to acne development than the actual fat or dairy content. Other studies have examined the effects of omega-3 fatty acid and γ-linoleic acid consumption in individuals with acne, showing individuals with acne benefit from diets consisting of fish and healthy oils, thereby increasing omega-3 and omega-6 fatty acid intake. Recent research into the effects of probiotic administration in individuals with acne present promising results; further study of the effects of probiotics on acne is needed to support the findings of these early studies.
Čini se da su hormoni koji se nazivaju androgeni kod oba spola dio osnovnog mehanizma, uzrokujući povećanu proizvodnju sebuma. Još jedan čest faktor je pretjerani rast bakterije Cutibacterium acnes, koja je prisutna na koži.
Obično se koriste tretmani koji se primenjuju direktno na zahvaćenu kožu, kao što su azelaična kiselina, benzoil peroksid i salicilna kiselina. Antibiotici i retinoidi su dostupni u formulacijama koje se nanose na kožu i uzimaju na usta za liječenje akni. Međutim, rezistencija na antibiotike može se razviti kao rezultat terapije antibioticima. Nekoliko vrsta kontracepcijskih pilula može pomoći u sprječavanju akni kod žena. Rano i agresivno liječenje akni korištenjem izotretinoina može biti od pomoći za smanjenje dugoročnih komplikacija kod pojedinaca.
○ Tretman
Adapalen gel se može široko koristiti jer potiskuje lučenje sebuma i djeluje na suzbijanje ponovnog pojavljivanja akni. Adapalen gel može iritirati kožu ako se u početku nanese previše. Benzoil peroksid i azelainska kiselina, s druge strane, mogu se koristiti na upalnim mjestima akni jer pomažu kod upale. Općenito, potrebno je dugotrajno liječenje od mjesec dana ili više da bi se vidio učinak.
#Benzoyl peroxide [OXY-10]
#Adapalene gel [Differin]
#Tretinoin cream
#Minocycline
#Isotretinoin
#Topical clindamycin
#Comedone extraction