Amyloidosis - Amiloidoza
☆ U rezultatima Stiftung Warentest-a za 2022. iz Njemačke, zadovoljstvo potrošača ModelDerm-om bilo je samo nešto niže nego s plaćenim telemedicinskim konsultacijama.
Klasične crte lica Amiloidoza (Amyloidosis)
References
Žena stara 26 godina došla je u našu kliniku i požalila se na osip na nogama koji svrbi i koji je imala 10 godina. Uprkos korištenju steroidnih krema i tazarotena, osip se nije poboljšao. Nije imala relevantnu porodičnu istoriju. Kada smo je pregledali, našli smo uzdignute, hrapave mrlje na prednjoj strani njenih nogu, koje su odgovarale bolesti zvanoj lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
Lichen Amyloidosis je rijetko stanje kože povezano s upornim svrabom nepoznatog uzroka. Obično se pojavljuje kao nakupine uzdignutih, promijenjenih mrlja na vanjskim površinama kože. Lichen Amyloidosis se obično javlja kod ljudi od 50 do 60 godina i nažalost, ne postoji lijek za to. Tretmani koji su sada dostupni obično ne rade dobro.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen amyloidosis je dugotrajno stanje kože sa svrabom. Poznat je po nakupinama zadebljanih kvržica koje se uglavnom nalaze na leđima, potkoljenicama, bedrima i rukama. Kada se pregleda pod mikroskopom, Lichen amyloidosis pokazuje nakupljanje amiloida u gornjem sloju kože zajedno sa zadebljanjem i povećanjem vanjskog sloja kože. Iako tačan uzrok Lichen amyloidosis još nije u potpunosti shvaćen, prethodne studije su ga povezale s faktorima kao što su trljanje ili trenje o kožu, smrt ćelija, virusne infekcije, između ostalog. Čini se da je Lichen amyloidosis povezano sa nekoliko drugih stanja kože kao što je atopic dermatitis, lichen planus, and mycosis fungoides.
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
○ Dijagnoza i liječenje
#Electrophoresis of blood or urine
#Skin biopsy