Angiofibroma - Angiofibrom
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References
Cutaneous angiofibromas se može pojaviti na različitim dijelovima tijela. Na licu su često poznate kao fibrozne papule ili adenom sebaceum; na penisu se zovu pearly penile papules ; ispod nokta, oni se nazivaju periungualni angiofibromi ili Koenenovi tumori; a u ustima se nazivaju oralni fibromi. Angiofibromi lica su istaknuta karakteristika tuberous sclerosis (TS) , nasljednog poremećaja koji pogađa kožu, bubrege, srce, mozak i pluća. Obično se razvijaju na licu tokom detinjstva ili ranog odraslog doba kod osoba sa TS. Imati tri ili više angiofibroma lica ili dva ili više periungualnih angiofibroma smatra se značajnim u dijagnostici TS. Dodatno, višestruki angiofibromi lica mogu biti prisutni u stanjima (multiple endocrine neoplasia type 1 (MEN-1) i Birt-Hogg-Dubé syndrome) . Pearly penile papules se nalaze duž koronalne ivice i brazde penisa. To su uporne, bezbolne kvržice koje se češće vide kod neobrezanih muškaraca.
Cutaneous angiofibromas can be located on different areas of the body including the face where they are commonly called fibrous papules or adenoma sebaceum on the penis where they are called pearly penile papules, underneath the nail where they are called periungual angiofibromas or Koenen tumors, and in the mouth where they are called oral fibromas. Facial angiofibromas are considered one of the most obvious clinical presentations of tuberous sclerosis (TS), an autosomal dominant hamartomatous disorder that affects the skin, kidneys, heart, brain, and lungs. With TS, angiofibromas typically arise on the face in childhood and early adulthood. Both facial angiofibromas (greater than or equal to 3 needed) and periungual angiofibroma (greater than or equal to 2 needed) are 2 of the major criteria for TS. Multiple facial angiofibromas are also found in multiple endocrine neoplasia type 1 (MEN-1) and Birt-Hogg-Dube syndrome. Pearly penile papules are chronic, asymptomatic, papules found on the coronal margin and sulcus of the penis. They are more common in uncircumcised men.
Cutaneous angiofibromas can be located on different areas of the body including the face where they are commonly called fibrous papules or adenoma sebaceum on the penis where they are called pearly penile papules, underneath the nail where they are called periungual angiofibromas or Koenen tumors, and in the mouth where they are called oral fibromas. Facial angiofibromas are considered one of the most obvious clinical presentations of tuberous sclerosis (TS), an autosomal dominant hamartomatous disorder that affects the skin, kidneys, heart, brain, and lungs. With TS, angiofibromas typically arise on the face in childhood and early adulthood. Both facial angiofibromas (greater than or equal to 3 needed) and periungual angiofibroma (greater than or equal to 2 needed) are 2 of the major criteria for TS. Multiple facial angiofibromas are also found in multiple endocrine neoplasia type 1 (MEN-1) and Birt-Hogg-Dube syndrome. Pearly penile papules are chronic, asymptomatic, papules found on the coronal margin and sulcus of the penis. They are more common in uncircumcised men.
1) lice
Fibrous papule
2) penis
Pearly penile papule
3) ispod nokta na ruci ili nozi
Periungual angiofibroma