Drug eruption - Erupcija Droge
☆ U rezultatima Stiftung Warentest-a za 2022. iz Njemačke, zadovoljstvo potrošača ModelDerm-om bilo je samo nešto niže nego s plaćenim telemedicinskim konsultacijama.
Erupcija Droge (Drug eruption) karakterizira djelovanje na cijelo tijelo.
References
Kožne reakcije uzrokovane lijekovima, poznate kao erupcije lijekova, ponekad mogu biti teške. Ove teške reakcije, nazvane severe cutaneous adverse drug reactions (SCARs) , smatraju se opasnim po život. Oni uključuju uslove poput Stevens-Johnson syndrome (SJS) , toxic epidermal necrolysis (TEN) , acute generalized exanthematous pustulosis (AGEP) , and drug reaction with eosinophilia and systemic symptoms (DRESS) . Dok su SCARs rijetki, oko 2% hospitaliziranih pacijenata ih doživljava.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
31-godišnja žena je posjetila dermatološko odjeljenje sa bezbolnom crvenom flekom na gornjem desnom dijelu stopala. Uzela je jednu dozu doksiciklina (100 mg) dan ranije, nakon pikosekundnog laserskog tretmana za ožiljke od akni. Prošle godine je doživjela sličan problem na istom mjestu nakon što je uzela istu dozu doksiciklina nakon laserskog tretmana. Ona nema značajnu medicinsku anamnezu niti druge simptome, poput groznice, lokalno ili u cijelom tijelu.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
Stevens-Johnson syndrome (SJS) i toxic epidermal necrolysis (TEN) su dva oblika ozbiljne kožne reakcije, koja se razlikuju od drugih stanja kože kao što su eritema multiforme major i stafilokoknog sindroma opečene kože, kao i reakcija na lijekove. SJS/TEN je rijetka i teška reakcija koja uzrokuje široko rasprostranjeno oštećenje kože i sluzokože, često sa sistemskim simptomima. U preko 80% slučajeva uzrok su lijekovi.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Erupcije od droga se dijagnosticiraju uglavnom na osnovu anamneze i kliničkog pregleda. Biopsija kože, testovi krvi ili imunološki testovi također mogu biti korisni.
Primjeri uobičajenih lijekova koji uzrokuju erupciju su antibiotici i drugi antimikrobni lijekovi, sulfa lijekovi, nesteroidni protuupalni lijekovi (NSAID), hemoterapijski agensi za maligne bolesti, antikonvulzivi i psihotropni lijekovi.
○ Dijagnoza i liječenje
Ako imate groznicu (povišenu tjelesnu temperaturu), trebate potražiti liječničku pomoć što je prije moguće. Lijek za koji se sumnja treba prekinuti (npr. antibiotici, nesteroidni protuupalni lijekovi). Prije posjete bolnici, oralni antihistaminici kao što su cetirizin ili loratadin mogu pomoći kod svraba i osipa.
#Cetirizine [Zytec]
#LevoCetirizine [Xyzal]
#Loratadine [Claritin]
Krvni test (CBC, LFT, broj eozinofila)
Oralni steroidi i antihistaminici na recept lekara