Dysplastic nevus - Displastični Nevus
☆ U rezultatima Stiftung Warentest-a za 2022. iz Njemačke, zadovoljstvo potrošača ModelDerm-om bilo je samo nešto niže nego s plaćenim telemedicinskim konsultacijama.
Dysplastic nevi ― Za zapadnjake se preporučuje biopsija.
References
Dysplastic nevus , također poznat kao atipični ili Clarksov nevus, izazvao je debate u dermatologiji i dermatopatologiji. Doktori često vrše biopsiju ovih mladeža jer mogu izgledati nenormalno i izazvati zabrinutost zbog melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
Dysplastic nevi , također poznat kao atipični ili Clark nevusi, ponekad može dovesti do melanoma. Oko 36% melanoma nalazi se u blizini displastičnih nevusa. Znakovi da se displastični nevus može pretvoriti u melanom uključuju neujednačen oblik, više promjena pigmenta ili sivkastu boju. Ovi karcinomi se obično javljaju u mlađoj životnoj dobi (oko sredine tridesetih) , mogu biti višestruki i često se nalaze na trupu. Genetski, dysplastic nevi su između benignih nevusa i melanoma. Međutim, samo 20% do 30% melanoma dolazi iz postojećih nevusa. Budući da većina nevusa ne postaje melanom, obično se ne preporučuje njihovo preventivno uklanjanje.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Melanom je vrsta tumora koji nastaje kada melanociti, ćelije odgovorne za boju kože, postanu kancerogene. Melanociti potiču iz nervnog grebena. To znači da se melanomi mogu razviti ne samo na koži već iu drugim područjima gdje migriraju ćelije neuralnog grebena, poput gastrointestinalnog trakta i mozga. Stopa preživljavanja pacijenata sa ranim stadijumom melanoma (stadijum 0) je visoka i iznosi 97%, dok značajno pada na oko 10% za one sa dijagnozom uznapredovalog stadijuma bolesti (stadijum IV) .
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
○ Rizik od raka
Kao što se vidi kod belaca u Sjedinjenim Državama, oni sa displastičnim nevusima imaju doživotni rizik od razvoja melanoma veći od 10%. S druge strane, oni bez ikakvog displastičnog nevusa imaju rizik od razvoja melanoma manji od 1%.
○ Mjera opreza za osobe sa displastičnim nevusima
Samopregled kože se obično preporučuje za prevenciju melanoma (prepoznavanje atipičnih nevusa koji se mogu ukloniti) ili za rano otkrivanje postojećih tumora. Osobe sa ličnom ili porodičnom anamnezom raka kože ili višestrukih atipičnih nevusa trebalo bi da posete dermatologa najmanje jednom godišnje kako bi bili sigurni da ne razvijaju melanom.
Skraćenica [ABCDE] bila je korisna za pomoć zdravstvenim radnicima i laicima da upamte ključne karakteristike melanoma. Nažalost za prosječnu osobu, mnoge seboroične keratoze, neki lentigo senilis, pa čak i bradavice mogu imati karakteristike [ABCDE] i ne mogu se razlikovati od melanoma.
○ [ABCDE]
Asymmetrical: Asimetrična lezija kože.
Border: Granica lezije je nepravilna.
Color: melanomi obično imaju više nepravilnih boja.
Diameter: nevusi veći od 6 mm češće su melanomi nego manji nevusi.
Evolution: Evolucija (tj. promjena) nevusa ili lezije može ukazivati na to da lezija postaje maligna.