Melasma
☆ U rezultatima Stiftung Warentest-a za 2022. iz Njemačke, zadovoljstvo potrošača ModelDerm-om bilo je samo nešto niže nego s plaćenim telemedicinskim konsultacijama.
To je uobičajeno stanje uočeno kod azijskih žena u ranim 40-im godinama. Zaokružena lezija na fotografiji bliža je lentigu, a ne melazmi.
References
Tranexamic acid is a novel treatment option for melasma; however, there is no consensus on its use. This systematic review searched major databases for relevant publications to March 2016. Eleven studies with 667 participants were included. Pooled data from tranexamic acid-only observational studies with pre- and post-treatment Melasma Area and Severity Index (MASI) showed a decrease of 1.60 in MASI after treat?ment with tranexamic acid. The addition of tranexamic acid to routine treatment modalities resulted in a further decrease in MASI of 0.94. These results support the efficacy and safety of tranexamic acid, either alone or as an adjuvant to routine treatment modalities for melasma.
Nedavno je low-fluence Q-switched Nd:YAG (LFQSNY) laser postao popularan za liječenje melazme, posebno u Aziji. Sumiranje različitih studija bilo je izazovno, ali LFQSNY izgleda općenito djelotvoran i siguran za melazmu u poređenju s tradicionalnim terapijama. Međutim, neki slučajevi pjegave hipopigmentacije prijavljeni su kao nuspojava LFQSNY, vjerojatno zbog visoke energije lasera. Agresivna upotreba LFQSNY također može dovesti do hiperpigmentacije zbog upale, posebno kod tamnijih tonova kože.
Recently, the low-fluence Q-switched Nd:YAG laser (LFQSNY) has been widely used for treating melasma, especially in Asia. It was hard to summarize the heterogenous studies, but LFQSNY appeared to be a generally effective and safe treatment for melasma considering the results of previous conventional therapies. However, mottled hypopigmentation has been occasionally reported to develop and persist as an adverse event of LFQSNY, which may be associated with the high accumulated laser energy. When used aggressively, even LFQSNY can induce hyperpigmentation via unwanted inflammation, especially in darker skin.
Recently, the low-fluence Q-switched Nd:YAG laser (LFQSNY) has been widely used for treating melasma, especially in Asia. It was hard to summarize the heterogenous studies, but LFQSNY appeared to be a generally effective and safe treatment for melasma considering the results of previous conventional therapies. However, mottled hypopigmentation has been occasionally reported to develop and persist as an adverse event of LFQSNY, which may be associated with the high accumulated laser energy. When used aggressively, even LFQSNY can induce hyperpigmentation via unwanted inflammation, especially in darker skin.
Problemi s pigmentacijom se često nalaze u primarnoj zdravstvenoj zaštiti. Uobičajeni tipovi poremećaja hiperpigmentacije uključuju post-inflammatory hyperpigmentation, melasma, sunspots, freckles, and café au lait spots.
Pigmentation problems are often found in primary care. Common types of hyperpigmentation disorders include post-inflammatory hyperpigmentation, melasma, sunspots, freckles, café au lait spots.
Pigmentation problems are often found in primary care. Common types of hyperpigmentation disorders include post-inflammatory hyperpigmentation, melasma, sunspots, freckles, café au lait spots.
Melazma se ne može riješiti laserskim tretmanom u određenom vremenskom periodu, jer je to bolest u kojoj se pigment kontinuirano proizvodi. Tranxenemic kiselina pomaže poboljšanju u smanjenju pigmentacije.
○ Treatment
U nekim zemljama (npr. Japan, Koreja), oralna traneksamična kiselina je dostupna u slobodnoj prodaji i efikasna je. Krema za melazmu s traneksamskom kiselinom i azelainskom kiselinom može djelomično pomoći.
Hidrokinon se može koristiti lokalno za liječenje hiperpigmentacije, ali FDA je zaustavila OTC proizvode koji sadrže hidrokinon od 2020.
#Tranexamic acid [TRANSINO]
#Laser toning technique (low fluence QS1064 laser)
#Triluma