Onychomysosis - Onihomikoza
☆ U rezultatima Stiftung Warentest-a za 2022. iz Njemačke, zadovoljstvo potrošača ModelDerm-om bilo je samo nešto niže nego s plaćenim telemedicinskim konsultacijama.
Nokat na nozi zahvaćen Onihomikoza (Onychomysosis)
Stopalo osobe sa gljivičnom infekcijom noktiju deset sedmica nakon oralne terapije terbinafinom. Obratite pažnju na traku rasta zdravog nokta iza preostalih inficiranih noktiju.
References
Sistemski antimikotici su najefikasniji tretman. Meta-analiza pokazuje stope izlječenja mikotika na sljedeći način: terbinafine = 76%, itraconazole with pulse dosing = 63%, itraconazole with continuous dosing = 59%, fluconazole =48% . Istodobni debridman noktiju dodatno povećava stope izlječenja. Lokalna terapija sa ciclopirox je manje efikasna; ima stopu neuspjeha veću od 60%.
Systemic antifungals are the most effective treatment. Meta-analyses shows mycotic cure rates as follows: terbinafine = 76%, itraconazole with pulse dosing = 63%, itraconazole with continuous dosing = 59%, fluconazole =48%. Concomitant nail debridement further increases cure rates. Topical therapy with ciclopirox is less effective; it has a failure rate exceeding 60%.
Systemic antifungals are the most effective treatment. Meta-analyses shows mycotic cure rates as follows: terbinafine = 76%, itraconazole with pulse dosing = 63%, itraconazole with continuous dosing = 59%, fluconazole =48%. Concomitant nail debridement further increases cure rates. Topical therapy with ciclopirox is less effective; it has a failure rate exceeding 60%.
Onihomikoza je gljivična infekcija koja pogađa nokte. Kada ga uzrokuju dermatofiti, zove se tinea unguium. Onihomikoza uključuje infekcije uzrokovane dermatofitima, kvascima i plijesni. Problem s noktima koji nije uzrokovan gljivičnom infekcijom naziva se nail dystrophy. Iako može zahvatiti i nokte na rukama i nogama, onihomikoza noktiju na nogama je češća. Ovaj članak govori o različitim aspektima onihomikoze noktiju na nogama, kao što su njen utjecaj, klinički tipovi, stadiji, dijagnoza i liječenje. Iako nije opasna po život, onihomikoza može dovesti do ozbiljnih komplikacija kao što su celulitis, sepsa, infekcija kostiju, oštećenje tkiva i gubitak noktiju.
Onychomycosis is a fungal infection of the nail unit. When dermatophytes cause onychomycosis, this condition is called tinea unguium. The term onychomycosis encompasses the dermatophytes, yeasts, and saprophytic mold infections. An abnormal nail not caused by a fungal infection is a dystrophic nail. Onychomycosis can infect both fingernails and toenails, but onychomycosis of the toenail is much more prevalent. Discussed in detail in this activity are all evolving facets of the topic, including disease burden, clinical types, staging, diagnosis, and management of toenail onychomycosis. While non-life-threatening, onychomycosis can lead to severe complications such as cellulitis, sepsis, osteomyelitis, tissue damage, and nail loss.
Onychomycosis is a fungal infection of the nail unit. When dermatophytes cause onychomycosis, this condition is called tinea unguium. The term onychomycosis encompasses the dermatophytes, yeasts, and saprophytic mold infections. An abnormal nail not caused by a fungal infection is a dystrophic nail. Onychomycosis can infect both fingernails and toenails, but onychomycosis of the toenail is much more prevalent. Discussed in detail in this activity are all evolving facets of the topic, including disease burden, clinical types, staging, diagnosis, and management of toenail onychomycosis. While non-life-threatening, onychomycosis can lead to severe complications such as cellulitis, sepsis, osteomyelitis, tissue damage, and nail loss.
Terbinafine je lijek koji se bori protiv gljivičnih infekcija blokiranjem skvalen epoksidaze. Efikasan je protiv mnogih vrsta kožnih gljivica i odobren je za liječenje gljivica na noktima kada se uzima oralno. Dok je većina nuspojava poput glavobolje i želučanih tegoba manja i nestaje sama od sebe, promjene okusa (disgeuzija) mogu varirati od blagih do teških, što ponekad dovodi do gubitka težine. Trajne promjene okusa su rijetke, ali su prijavljene.
Terbinafine is an antifungal medication that works through the inhibition of squalene epoxidase. It has activity against most dermatophytes, and it has approval for use as an oral therapy for the treatment of onychomycosis. Although most side effects are mild and self-limited, such as headache and gastrointestinal symptoms, taste disturbances (dysgeusia) can range from mild to severe, resulting in weight loss, and have rarely been reported permanent.
Terbinafine is an antifungal medication that works through the inhibition of squalene epoxidase. It has activity against most dermatophytes, and it has approval for use as an oral therapy for the treatment of onychomycosis. Although most side effects are mild and self-limited, such as headache and gastrointestinal symptoms, taste disturbances (dysgeusia) can range from mild to severe, resulting in weight loss, and have rarely been reported permanent.
Onihomikoza je gljivična infekcija koja pogađa nokte. Oko 90% infekcija noktiju na nogama i 75% infekcija noktiju na rukama uzrokovano je gljivicama (Trichophyton mentagrophytes, Trichophyton rubrum) . Simptomi uključuju promjenu boje nokta, zadebljanje, odvajanje od nokatnog ležišta i prekomjerni rast. Liječenje obično uključuje oralne lijekove poput terbinafina ili itrakonazola, a lokalni tretmani su opcija za blage do umjerene slučajeve.
Onychomycosis is a fungal infection of the nail unit. Approximately 90% of toenail and 75% of fingernail onychomycosis are caused by dermatophytes, notably Trichophyton mentagrophytes and Trichophyton rubrum. Clinical manifestations include discoloration of the nail, subungual hyperkeratosis, onycholysis, and onychauxis. Currently, oral terbinafine is the treatment of choice, followed by oral itraconazole. In general, topical monotherapy can be considered for mild to moderate onychomycosis.
Onychomycosis is a fungal infection of the nail unit. Approximately 90% of toenail and 75% of fingernail onychomycosis are caused by dermatophytes, notably Trichophyton mentagrophytes and Trichophyton rubrum. Clinical manifestations include discoloration of the nail, subungual hyperkeratosis, onycholysis, and onychauxis. Currently, oral terbinafine is the treatment of choice, followed by oral itraconazole. In general, topical monotherapy can be considered for mild to moderate onychomycosis.
Čini se da je antifungalni lijek terbinafin koji se uzima na usta najefikasniji, ali je terbinafin povezan sa nuspojavama jetre.
onihomikoza (onychomysosis) se javlja kod oko 10 posto odrasle populacije, a češće oboljevaju stariji ljudi. Muškarci su češće pogođeni nego žene. onihomikoza (onychomysosis) predstavlja otprilike polovinu bolesti noktiju. To znači da deformitet noktiju na nogama može biti uzrokovan i drugim uzrocima osim onihomikoze.
○ Liječenje ― OTC lijekovi
Onikomikozu je teško liječiti lokalnim lijekovima jer lijekovi teško mogu prodrijeti u zadebljale nokte na nogama.
#Ketoconazole
#Clotrimazole
#Miconazole
#Terbinafine
#Butenafine [Lotrimin]
#Tolnaftate
○ Treatment
Obično je potrebno dugotrajno liječenje dok se inficirani nokat potpuno ne ukloni.
#Terbinafine (oral)
#Itraconazole
#Efinaconazole lacquer [Jublia]
#Ciclopirox lacquer