Više informacija ― Bosanski

Porokeratosis je rijetko stanje kože koje karakteriziraju problemi s keratinizacijom, što rezultira izdignutim, prstenastim mrljama ili grubim izbočinama na koži. Njegova definitivna karakteristika pod mikroskopom je prisustvo kornoidne lamele, specifičnog rasporeda ćelija u gornjem sloju kože. Porokeratosis dolazi u različitim oblicima, kao što je disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Važno je napomenuti da se porokeratosis potencijalno može razviti u rak kože. Najbolji način za postavljanje dijagnoze porokeratosis je biopsija podignute granice, iako trenutno ne postoji standardni protokol liječenja.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.

Disseminated superficial actinic porokeratosis (DSAP) je bolest poremećene keratinizacije. To je jedan od šest tipova porokeratoze, i obično zahvaća veće površine u odnosu na ostale (linear, Mibelli's, punctate, palmoplantar disseminated, and superficial porokeratosis) . Eruptivni tip porokeratoze često je povezan s rakom, oslabljenim imunitetom ili upalom. Faktori rizika uključuju genetiku, supresiju imuniteta i izlaganje suncu. DSAP počinje kao ružičaste ili smeđe kvrge sa podignutim ivicama na područjima izloženim suncu, ponekad uzrokujući blagi svrab. Tretmani se razlikuju i mogu uključivati ​​topikalne kreme, terapiju svjetlom ili lijekove poput 5-fluorouracila ili retinoida. Ove lezije se smatraju prekanceroznim, sa 7. 5 - 10 % šansom da se pretvore u karcinom skvamoznih ili bazalnih ćelija.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.

Muškarac star 52 godine, ranije zdrav, došao je sa ravnom, prstenastom mrljom na kraju četvrtog nožnog prsta, koja je bila tu 2 godine bez ikakvih simptoma. Počelo je kao mala, tvrda kvrga i vremenom je rasla prema van. Uprkos pokušajima raznih tretmana kao što su krioterapija, kreme, antifungici i antibiotici, flaster se nije poboljšao. Pomno ispitivanje dermokopijom pokazalo je suvo, crveno središte sa debelim, grubim rubom. Mali komad kože uzet sa ivice flastera pokazao je abnormalni rast ćelija u spoljašnjem sloju kože, potvrđujući dijagnozu porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.