Syphilis - Sifilis
☆ U rezultatima Stiftung Warentest-a za 2022. iz Njemačke, zadovoljstvo potrošača ModelDerm-om bilo je samo nešto niže nego s plaćenim telemedicinskim konsultacijama.
Chancres ― primarna sifilitička infekcija od Treponema pallidum
References
Sifilis je spolno prenosiva bolest koju uzrokuje bakterija Treponema pallidum. U ovoj studiji fokusirali smo se na 57 pacijenata u dobi od 18-68 godina sa sekundarnim sifilisom.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Sifilis je bakterijska infekcija uzrokovana Treponema pallidum. Može oponašati razne bolesti, zbog čega je dobio nadimak great imitator. Sifilis i dalje pogađa milione ljudi širom sveta, ali se može efikasno lečiti penicilinom.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Treponema pallidum izaziva sifilis seksualnim kontaktom ili sa majke na bebu tokom trudnoće. Iako postoje jednostavni testovi za dijagnosticiranje i liječenje jednom injekcijom dugodjelujućeg penicilina dobro funkcionira, sifilis ponovo postaje veliki problem širom svijeta. Ovo posebno važi za muškarce koji imaju seks sa muškarcima (MSM) u zemljama sa visokim i srednjim prihodima. Dok su neke zemlje sa niskim dohotkom ispunile ciljeve SZO da zaustave prelazak sifilisa s majke na bebu, postoji zabrinjavajući porast sifilisa među HIV pozitivnim MSM.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
(1) Povećana jetra: Ovo se često nalazi i može se dogoditi uz povećanu slezinu. Ispitivanje biopsije jetre pod mikroskopijom u tamnom polju može otkriti prisustvo spirohete. Testovi funkcije jetre mogu pokazati abnormalnosti. (2) Žutilo kože (žutica) : da li će neko pokazati žuticu zavisi od toga koliko je jetra zahvaćena. (3) Curenje iz nosa: Često jedan od prvih znakova, obično unutar prve sedmice nakon rođenja. (4) Otečeni limfni čvorovi: Generalizovano oticanje limfnih čvorova, obično bezbolno, takođe je uobičajeno. (5) Osip na koži: Osip se obično pojavljuje jednu do dvije sedmice nakon curenja iz nosa. Možete vidjeti male crvene ili ružičaste mrlje na leđima, zadnjici, bedrima i tabanima. Ovaj osip može napredovati do ljuštenja i stvaranja kora.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
○ Dijagnoza i liječenje
VDRL i RPR se mogu koristiti za potvrdu nedavne infekcije i pregled na sifilis. FTA-ABS test je specifičniji test i može se koristiti za provjeru prethodne istorije infekcije. Penicilin se koristi za liječenje sifilisa.