Toxic epidermal necrosis - Toksična Epidermalna Nekroza
☆ U rezultatima Stiftung Warentest-a za 2022. iz Njemačke, zadovoljstvo potrošača ModelDerm-om bilo je samo nešto niže nego s plaćenim telemedicinskim konsultacijama.
Karakterističan gubitak kože od Toksična Epidermalna Nekroza (Toxic epidermal necrosis)
References
Stevens-Johnson Syndrome (SJS) i Toxic Epidermal Necrolysis (TEN) su rijetka stanja u kojima koža doživljava opsežnu nekrozu i ljuštenje. Što se tiče liječenja, ciklosporin je vrlo efikasan za SJS, dok kombinacija intravenoznog imunoglobulina (IVIg) i kortikosteroida najbolje djeluje u slučajevima SJS i TEN.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Toxic epidermal necrolysis (TEN) je ozbiljna kožna reakcija uzrokovana određenim lijekovima i djelovanjem imunološkog sistema, što rezultira velikim odvajanjem vanjskog sloja kože (epidermisa) , zahvaćajući više od 30% površine tijela. TEN ima stopu smrtnosti od preko 20%, često zbog infekcija i poteškoća s disanjem. Prestanak uzimanja lijeka koji uzrokuje reakciju, pružanje potporne njege i korištenje dodatnih tretmana može poboljšati ishod. Nedavne studije su pokazale da lijekovi kao što su ciklosporin, inhibitori faktora nekroze tumora alfa i kombinacija intravenoznog imunoglobulina i kortikosteroida mogu biti od pomoći, na osnovu randomiziranih kontroliranih studija i analiza višestrukih studija.
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Recent Advances: There is improved understanding of pain and morbidity with regard to the type and frequency of dressing changes. More modern dressings, such as nanocrystalline, are currently favored as they may be kept in situ for longer periods. The most recent evidence on systemic agents, such as corticosteroids and cyclosporine, and novel treatments, are also discussed.
Najčešći uzrok su određeni lijekovi kao što su lamotrigin, karbamazepin, alopurinol, sulfonamidni antibiotici i nevirapin. Faktori rizika uključuju HIV i sistemski eritematozni lupus. Liječenje se obično odvija u bolnici, kao što je jedinica za opekotine ili jedinica intenzivne njege.
○ Treatment
Ovo je ozbiljna bolest, pa ako su vaše usne ili usta zahvaćene ili koža dobije mjehuriće, posjetite liječnika što je prije moguće.
Sumnjive lijekove treba prekinuti. (npr. antibiotici, nesteroidni protuupalni lijekovi)