Urticaria pigmentosa - Pigmentosa Urtikarije
Pigmentosa Urtikarije (Urticaria pigmentosa) je najčešći oblik kožne mastocitoze. To je rijetka bolest uzrokovana prekomjernim brojem mastocita u koži koji izazivaju koprivnjaču ili lezije na koži kada je iritirana. Crvene ili smeđe mrlje često se vide na koži, obično oko grudi, čela i leđa. Ovi mastociti, kada su iritirani (npr. trljanjem kože, izlaganjem toploti), proizvode previše histamina, pokrećući alergijsku reakciju koja dovodi do koprivnjače lokalizirane na području iritacije, što se ponekad naziva i "Darijevim znakom".
☆ U rezultatima Stiftung Warentest-a za 2022. iz Njemačke, zadovoljstvo potrošača ModelDerm-om bilo je samo nešto niže nego s plaćenim telemedicinskim konsultacijama.
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Mastocytosis je stanje u kojem postoji višak mastocita, koji se često nalaze u različitim dijelovima tijela kao što su koža, koštana srž i probavni sistem. Prema Svjetskoj zdravstvenoj organizaciji (WHO) , cutaneous mastocytosis se može kategorizirati u tri glavna tipa. Prvi tip (mastocytomas) sastoji se od pojedinačnih ili nekoliko (≤3) lezija. Drugi tip (urticaria pigmentosa) uključuje višestruke lezije, obično u rasponu od više od 10 do manje od 100. Posljednji tip pokazuje široko rasprostranjenu zahvaćenost po koži. Urticaria pigmentosa je najčešći oblik kožne mastocitoze kod djece, ali se može javiti i kod odraslih. Obično je to bezopasno stanje koje se često poboljšava tokom adolescencije. Za razliku od mastocitoze odraslih, urticaria pigmentosa rijetko zahvaća unutrašnje organe. Jedna karakteristična karakteristika urticaria pigmentosa je njegova sklonost izazivanju malih, svrbež, crvenkasto-smeđih ili žućkasto-smeđih mrlja ili lezija na koži, poznatih kao koprivnjača. Ove mrlje se obično pojavljuju u djetinjstvu i mogu trajati cijeli život.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
Došla je šestogodišnja djevojčica sa nekoliko tamnih mrlja koje su se prvo pojavile na njenom tjemenu, a zatim se proširile na lice i tijelo u posljednjih šest mjeseci. Spomenula je da osjeća kako se podižu, pocrvene i svrbe kada se izvrši pritisak. Nije imala crvenilo, povraćanje, dijareju ili piskanje, a njena lična i porodična medicinska istorija nije dala relevantne tragove. Pregledom smo pronašli više tamnih mrlja na njenom tjemenu, čelu, licu i vratu, zajedno sa blago podignutim tamnim mrljama na grudima i leđima. Lagano trljanje mrlja izazvalo je oticanje i svrab u roku od 2 minute, ali su simptomi nestali u roku od 15-20 minuta (Darier's sign) .
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
