Keratoacanthoma - Queratoacantoma
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Típic Queratoacantoma (Keratoacanthoma)
References
Keratoacanthoma (KA) és un tumor de pell freqüent conegut pel seu creixement ràpid i potencial per retrocedir per si mateix. Normalment es produeix en homes grans i de pell clara amb antecedents de danys solars. Tot i que l'extirpació quirúrgica mitjançant l'excisió o la cirurgia microgràfica de Mohs és el tractament habitual, hi ha altres opcions de teràpia disponibles.
Keratoacanthoma (KA) is a common cutaneous tumor characterized by rapid growth and possible spontaneous regression. It most commonly affects older, fair-skinned males with significantly sun damaged skin. Although surgical removal with excision or Mohs micrographic surgery remains the standard of therapy, there are many alternative therapeutic modalities that can be utilized.
Keratoacanthoma (KA) is a common cutaneous tumor characterized by rapid growth and possible spontaneous regression. It most commonly affects older, fair-skinned males with significantly sun damaged skin. Although surgical removal with excision or Mohs micrographic surgery remains the standard of therapy, there are many alternative therapeutic modalities that can be utilized.
Keratoacanthoma (KA) és un tumor de baix grau que s'inicia en determinades glàndules de la pell i sembla semblant a squamous cell carcinoma (SCC) sota un microscopi. Hi ha un debat en curs sobre si la KA s'ha de classificar com una forma de SCC invasiu.
Keratoacanthoma (KA) is a comparatively common low-grade tumor that initiates in the pilo-sebaceous glands and pathologically mimics squamous cell carcinoma (SCC). Essentially, strong debates confirm classifying keratoacanthoma as a variant of invasive SCC. The clinical behavior of KA is hardly predictable and the differential diagnosis of keratoacanthoma and other conditions with keratoacanthoma-like pseudocarcinomatous epithelial hyperplasia is challenging, both clinically and histopathologically.
Keratoacanthoma (KA) is a comparatively common low-grade tumor that initiates in the pilo-sebaceous glands and pathologically mimics squamous cell carcinoma (SCC). Essentially, strong debates confirm classifying keratoacanthoma as a variant of invasive SCC. The clinical behavior of KA is hardly predictable and the differential diagnosis of keratoacanthoma and other conditions with keratoacanthoma-like pseudocarcinomatous epithelial hyperplasia is challenging, both clinically and histopathologically.
Cutaneous squamous cell carcinoma (cSCC) és el segon tipus de càncer més comú en les persones, especialment entre les persones grans. La cirurgia s'utilitza normalment per tractar el cSCC, però per a alguns pacients que no es poden operar o decideixen no fer-ho, es poden considerar altres opcions com els tractaments intralesionals. S'han utilitzat tractaments intralesionals tradicionals (methotrexate or 5-fluorouracil) , però hi ha investigacions en curs sobre nous enfocaments com la immunoteràpia intralesional i la viroteràpia oncolítica. A continuació, veurem diferents tractaments intralesionals per al cSCC, que van des dels mètodes clàssics fins a les estratègies d'avantguarda.
Cutaneous squamous cell carcinoma (cSCC) is the second most frequent cancer in humans, and it is especially common in fragile, elderly people. Surgery is the standard treatment for cSCC but intralesional treatments can be an alternative in those patients who are either not candidates or refuse to undergo surgery. Classic intralesional treatments, including methotrexate or 5-fluorouracil, have been implemented, but there is now a landscape of active research to incorporate intralesional immunotherapy and oncolytic virotherapy into the scene, which might change the way we deal with cSCC in the future. In this review, we focus on intralesional treatments for cSCC (including keratoacanthoma), from classic to very novel strategies.
Cutaneous squamous cell carcinoma (cSCC) is the second most frequent cancer in humans, and it is especially common in fragile, elderly people. Surgery is the standard treatment for cSCC but intralesional treatments can be an alternative in those patients who are either not candidates or refuse to undergo surgery. Classic intralesional treatments, including methotrexate or 5-fluorouracil, have been implemented, but there is now a landscape of active research to incorporate intralesional immunotherapy and oncolytic virotherapy into the scene, which might change the way we deal with cSCC in the future. In this review, we focus on intralesional treatments for cSCC (including keratoacanthoma), from classic to very novel strategies.
Al microscopi, queratoacantoma (keratoacanthoma) s'assembla molt al carcinoma de cèl·lules escamoses. Tot i que alguns patòlegs classifiquen el queratoacantoma (keratoacanthoma) com una entitat diferent i no com una malignitat, al voltant del 6% dels queratoacantoma (keratoacanthoma) clínics i histològics progressen cap a càncers de cèl·lules escamoses invasives i agressives.
○ Diagnòstic i tractament
#Dermoscopy
#Skin biopsy