Livedoid vasculitis - Vasculitis Livedoid
La Vasculitis Livedoid (Livedoid vasculitis) és una malaltia cutània crònica que es veu predominantment en dones joves i de mitjana edat. Un acrònim utilitzat per descriure les seves característiques és "Úlceres purpúriques doloroses amb patró reticular de les extremitats inferiors" (MORAT). S'associa a diverses malalties, com ara la hipertensió venosa crònica i varicositats.
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Pot anar acompanyat de dolor.
References
Livedoid vasculopathy és una malaltia rara de la pell caracteritzada per úlceres doloroses que continuen tornant a la part inferior de les cames.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy és una malaltia rara de la pell que causa úlceres recurrents a la part inferior de les cames, deixant enrere cicatrius pàl·lides conegudes com a atròfia blanca. Tot i que la causa exacta encara no està clara, es creu que l'augment de la coagulació de la sang (hypercoagulability) és el factor principal, amb la inflamació jugant un paper secundari. Els factors que contribueixen a la coagulació inclouen els següents: deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. En les biòpsies, la malaltia mostra coàguls de sang a l'interior dels vasos, engrossiment de les parets dels vasos i cicatrius. El tractament implica un enfocament polivalent que se centra en la prevenció de coàguls de sang amb medicaments com antiplaquetàries, anticoagulants i teràpia fibrinolítica. Es poden utilitzar diversos fàrmacs per a aquesta malaltia de la pell - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy és una condició rara on es produeixen lesions a les dues cames. Es creu que la formació de coàguls de sang en petits vasos sanguinis és causada per l'augment de la coagulació i la reducció de la degradació dels coàguls, juntament amb el dany al revestiment dels vasos. És més freqüent en dones, especialment entre els 15 i els 50 anys. Deixar de fumar, tenir cura de les ferides i utilitzar medicaments com anticoagulants i antiplaquetàries han estat eficaços.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
