Panniculitis - Paniculitis
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La tuberculosi és una de les causes importants.
References
Erythema nodosum is the most common form of panniculitis and is characterized by tender erythematous nodules mainly in the lower limbs on the pretibial area. The exact cause of erythema nodosum is unknown, although it appears to be a hypersensitivity response to a variety of antigenic stimuli. Although the etiology is mostly idiopathic, ruling out an underlying disease is imperative before diagnosing primary erythema nodosum. Erythema nodosum can be the first sign of a systemic disease that is triggered by a large group of processes, such as infections, inflammatory diseases, neoplasia, and/or drugs. The most common identifiable causes are streptococcal infections, primary tuberculosis, sarcoidosis, Behçet disease, inflammatory bowel disease, drugs, and pregnancy.
Panniculitis formen un grup heterogeni de malalties inflamatòries que afecten el teixit adipós subcutani. Aquests trastorns són rars en nens. La paniculitis pot ser el procés primari en un trastorn sistèmic o un procés secundari que resulta d'una infecció, un trauma o l'exposició a la medicació. La majoria dels tipus de paniculitis tenen la mateixa presentació clínica (independentment de l'etiologia) , amb nòduls subcutani tendres i eritematosos.
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.
Panniculitis , inflamació del greix subcutani, sol presentar-se amb nòduls inflamatoris. Erythema nodosum (EN) és clínicament la forma més freqüent de paniculitis. Tot i que fins al 55% de les EN es considera idiopàtica, les causes més freqüents inclouen infeccions, fàrmacs, malalties sistèmiques com la sarcoïdosi i la malaltia inflamatòria intestinal, l'embaràs i la malignitat. L'EN sol presentar-se a l'adolescència i als 20 anys, i s'observa més freqüentment en les dones. Sovint va precedit d'un pròdrom inespecífic d'una a tres setmanes, que pot incloure febre, malestar i símptomes d'una infecció del tracte respiratori superior. A continuació, segueixen lesions cutànies, típicament localitzades a l'aspecte extensor de les extremitats. Les lesions són doloroses, arrodonides o ovalades, lleugerament elevades, nòduls vermells no ulcerosos. No s'entén la patogènesi exacta de l'EN, tot i que es creu que és el resultat de la deposició de complexos immunitaris a les vènules dels septes en el greix subcutani, provocant una paniculitis neutròfila. Fins i tot sense una teràpia específica per a una malaltia causant, la EN es resol sense tractament en la majoria dels casos.
Panniculitis, inflammation of the subcutaneous fat, usually presents with inflammatory nodules. Erythema nodosum (EN) is clinically the most frequent form of panniculitis. Whilst up to 55% of EN is considered idiopathic, the most common causes include infections, drugs, systemic illnesses such as sarcoidosis and inflammatory bowel disease, pregnancy, and malignancy. EN typically presents in the teens and 20s, and is seen more commonly in females. It is often preceded by a non-specific prodrome of one to three weeks, which may include fever, malaise, and symptoms of an upper respiratory tract infection. Cutaneous lesions then follow, typically localized on the extensor aspect of the limbs. The lesions are painful rounded or oval, slightly raised, non-ulcerative red nodules. The exact pathogenesis of EN is not understood, although is thought to result from deposition of immune complexes in the venules of the septae in subcutaneous fat, causing a neutrophilic panniculitis. Even without specific therapy for a causative condition, EN resolves without treatment in most cases.
Panniculitis, inflammation of the subcutaneous fat, usually presents with inflammatory nodules. Erythema nodosum (EN) is clinically the most frequent form of panniculitis. Whilst up to 55% of EN is considered idiopathic, the most common causes include infections, drugs, systemic illnesses such as sarcoidosis and inflammatory bowel disease, pregnancy, and malignancy. EN typically presents in the teens and 20s, and is seen more commonly in females. It is often preceded by a non-specific prodrome of one to three weeks, which may include fever, malaise, and symptoms of an upper respiratory tract infection. Cutaneous lesions then follow, typically localized on the extensor aspect of the limbs. The lesions are painful rounded or oval, slightly raised, non-ulcerative red nodules. The exact pathogenesis of EN is not understood, although is thought to result from deposition of immune complexes in the venules of the septae in subcutaneous fat, causing a neutrophilic panniculitis. Even without specific therapy for a causative condition, EN resolves without treatment in most cases.
"Eritema nodos" és una forma de paniculitis (panniculitis) caracteritzada per nòduls vermells tendres, d'1 a 10 cm, associats a símptomes sistèmics com febre, malestar general i dolor articular. Els nòduls poden disminuir durant un període de 2 a 6 setmanes sense ulceració ni cicatrius. L'eritema nodos s'associa amb infeccions, com ara l'hepatitis C, el VEB i la tuberculosi, l'embaràs, el limfoma no Hodgkin i el càncer de pàncrees.