Acute generalized exanthematous pustulosis
L' Acute generalized exanthematous pustulosis (AGEP) hè una reazione rara di a pelle chì in u 90% di i casi hè ligata à l'amministrazione di medicazione. L' acute generalized exanthematous pustulosis hè carattarizata da eruzioni cutanee subite chì appariscenu in media cinque ghjorni dopu à l'iniziu di a medicazione. Queste eruzioni sò pustuli, vale à dì una piccula eruzione rossa bianca o rossa di a pelle chì cuntene materiale nuvoloso o purulentu (pus). E lesioni di a pelle sò generalmente risolve in 1-3 ghjorni da a cessazione di a medicazione offensiva.
☆ In i risultati Stiftung Warentest 2022 da Germania, a satisfaczione di i cunsumatori cù ModelDerm era solu ligeramente più bassu chè cù cunsultazioni di telemedicina pagate.
Lesioni diffusa cù eritema è pustuli appariscenu di colpu.
References
Acute generalized exanthematous pustulosis (AGEP) hè una reazione di a pelle marcata da picculi protuberi pieni di pus nantu à una basa di a pelle rossa. Di solitu succede quandu qualchissia piglia certi medicazione, cum'è l'antibiotici, è si sparghje rapidamente in u corpu. Dopu avè cessatu a medicazione attivante, i sintomi spariscenu in solitu in duie simane, spessu lascendu una certa perdita di a pelle. Ancu s'ellu ùn hè di solitu micca seriu è limitatu à a pelle, i casi severi ponu esse classificati cù altre reazzioni di a pelle seria cum'è Stevens-Johnson syndrome o toxic epidermal necrolysis. U trattamentu hè principarmenti cura di supportu, è u pronostico per a risoluzione completa di a malatia hè generalmente eccellente.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
Un omu di 76 anni hè ghjuntu à a sala d'urgenza perchè a so pelle avia cambiatu in l'ultimi dui ghjorni. I medichi anu trovu macchie rosse è spazii elevati nantu à u so troncu è i braccia è i gammi. Quandu u tempu passava, sti patch si uniscenu, è hà sviluppatu bumps cum'è pimple in i zoni rossi. I testi anu dimustratu un altu numeru di globuli bianchi cù assai di un tipu chjamatu neutrofili, è livelli aumentati di C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
