Amyloidosis - Amiloidosi
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Funzioni facciali classiche di Amiloidosi (Amyloidosis)
References
Una donna di 26 anni hè ghjunta à a nostra clinica chì si lamentava di una rash pruriginosa in e so gambe chì avia avutu dapoi 10 anni. Malgradu l'usu di creme steroidi è crema di tazarotene, a rash ùn hè micca megliu. Ùn avia micca una storia di famiglia pertinente. Quandu l'avemu esaminata, truvamu petti rialzati è ruvidi nantu à u fronte di e so gammi, chì currispondenu à una malatia chjamata lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
Lichen Amyloidosis hè una cundizione rara di a pelle ligata à prurito persistente di causa scunnisciuta. Di solitu si prisenta cum'è gruppi di pezze scolpite è scolorite nantu à a superficia esterna di a pelle. Lichen Amyloidosis appare di solitu in e persone da 50 à 60 anni è, sfurtunatamenti, ùn ci hè cura per questu. I trattamenti dispunibuli avà ùn sò generalmente micca bè.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen amyloidosis hè una cundizione di pelle pruriginosa di longa durata. Hè cunnisciutu per i gruppi di bumps grossi chì si trovanu principarmenti nantu à u spinu, stinchi, cosce è braccia. Quandu esaminatu sottu un microscopiu, Lichen amyloidosis mostra un accumulu di amiloide in a capa superiore di a pelle cù l'ingrossu è l'allargamentu di a capa esterna di a pelle. Ancu s'è a causa esatta di Lichen amyloidosis ùn hè micca capitu cumplettamente, studii precedenti l'anu ligatu à fatturi cum'è strofinamentu o attritu nantu à a pelle, morte cellulare, infezioni virali, frà altri. Lichen amyloidosis pare esse ligatu cù parechje altre cundizione di a pelle (atopic dermatitis, lichen planus, mycosis fungoides) .
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
○ Diagnosi è Trattamentu
#Electrophoresis of blood or urine
#Skin biopsy