Herpes simplex - Herpes Simplice
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Herpes simplex nantu à a labbra.
Herpes Simplice (Herpes simplex) ― L'infezione da Herpes simplex in i dite hè più cumuni in i zitelli chì in l'adulti.
References
L'infezione da HSV-1 avanza per l'infezione primaria di e cellule epiteliali, seguita da a latenza, principalmente in i neuroni, è a riattivazione. L'HSV-1 generalmente provoca eruzioni vesiculari iniziali è recurrenti, principarmenti nantu à a bocca è a mucosa genitale. E so manifestazioni varienu da l'herpes orolabial à diverse cundizioni cum'è folliculitis herpetica, infezioni di a pelle, implicazione oculare, è casi severi cum'è l'encefalite herpes. A terapia antivirale aiuta à gestisce l'infezione da HSV.
Herpes simplex virus type 1 (HSV-1) is a member of the Alphaherpesviridae subfamily. Its structure is composed of linear dsDNA, an icosahedral capsid that is 100 to 110 nm in diameter, with a spikey envelope. In general, the pathogenesis of HSV-1 infection follows a cycle of primary infection of epithelial cells, latency primarily in neurons, and reactivation. HSV-1 is responsible for establishing primary and recurrent vesicular eruptions, primarily in the orolabial and genital mucosa. HSV-1 infection has a wide variety of presentations, including orolabial herpes, herpetic sycosis (HSV folliculitis), herpes gladiatorum, herpetic whitlow, ocular HSV infection, herpes encephalitis, Kaposi varicelliform eruption (eczema herpeticum), and severe or chronic HSV infection. Antiviral therapy limits the course of HSV infection.
Herpes simplex virus type 1 (HSV-1) is a member of the Alphaherpesviridae subfamily. Its structure is composed of linear dsDNA, an icosahedral capsid that is 100 to 110 nm in diameter, with a spikey envelope. In general, the pathogenesis of HSV-1 infection follows a cycle of primary infection of epithelial cells, latency primarily in neurons, and reactivation. HSV-1 is responsible for establishing primary and recurrent vesicular eruptions, primarily in the orolabial and genital mucosa. HSV-1 infection has a wide variety of presentations, including orolabial herpes, herpetic sycosis (HSV folliculitis), herpes gladiatorum, herpetic whitlow, ocular HSV infection, herpes encephalitis, Kaposi varicelliform eruption (eczema herpeticum), and severe or chronic HSV infection. Antiviral therapy limits the course of HSV infection.
Herpes simplex virus type 2 (HSV-2) hè una infezione diffusa, chì affetta circa 22% di l'adulti di 12 anni è sopra, per un totale di 45 milioni di adulti in i Stati Uniti. Mentre chì l'HSV-1 tipicamenti provoca ferite orali, pò ancu purtà à lesioni genitali. In ogni casu, quandu i pazienti anu lesioni genitali, HSV-2 hè di solitu a preoccupazione principale. I sintomi di u focu di HSV-2 sò spessu vagi, cum'è prurito è irritazione genitale, chì ponu ritardà u diagnosticu è u trattamentu. Stu ritardu pò risultà in più trasmissioni à individui micca infettati.
Herpes simplex virus type 2 (HSV-2) continues to be a common infection, affecting approximately 22% of adults ages 12 and older, representing 45 million adults in the United States alone. While HSV-1 often affects the perioral region and can be known to cause genital lesions, HSV-2 is more commonly the consideration when patients present with genital lesions. Despite this, most outbreaks of the infection will present with nonspecific symptoms such as genital itching, irritation, and excoriations, which may cause diagnosis and treatment to be delayed. As a result, further exposure to uninfected individuals may occur.
Herpes simplex virus type 2 (HSV-2) continues to be a common infection, affecting approximately 22% of adults ages 12 and older, representing 45 million adults in the United States alone. While HSV-1 often affects the perioral region and can be known to cause genital lesions, HSV-2 is more commonly the consideration when patients present with genital lesions. Despite this, most outbreaks of the infection will present with nonspecific symptoms such as genital itching, irritation, and excoriations, which may cause diagnosis and treatment to be delayed. As a result, further exposure to uninfected individuals may occur.
Herpes simplex virus (HSV) generalmente provoca infezioni cum'è l'herpes genitale è l'herpes labiali in l'adulescenti è l'adulti. Quandu HSV infetta un zitellu in e prime 4-6 simane di vita, pò esse risultatu in una malatia severa cù cunsequenze gravi. A diagnosi rapida di l'infezione da HSV neonatale hè cruciale per impedisce a malatia di peghju, prevenendu prublemi neurologichi (ancu a morte) .
Herpes simplex virus (HSV), a member of the Herpesviridae family, is a well-known cause of infections including genital herpes and herpes labialis in the adolescent and adult population. Transmission of HSV infection to an infant during the first 4-6 weeks of life can lead to devastating disease with the potential for poor outcomes. Early diagnosis is imperative when evaluating neonatal HSV infection in order to prevent further disease progression, neurological complications, and even death.
Herpes simplex virus (HSV), a member of the Herpesviridae family, is a well-known cause of infections including genital herpes and herpes labialis in the adolescent and adult population. Transmission of HSV infection to an infant during the first 4-6 weeks of life can lead to devastating disease with the potential for poor outcomes. Early diagnosis is imperative when evaluating neonatal HSV infection in order to prevent further disease progression, neurological complications, and even death.
L'infezzione Herpes simplex hè assai cumuna è pò esse trasmessa da e donne incinte à i so figlioli. Stu virus pò causà gravi prublemi di salute o ancu morte in i neonati. Mentri hè raru durante a gravidanza stessu, spessu succede durante u partitu. U risicu hè più altu se a mamma hè infettata in l'ultimi fasi di a gravidanza. Tuttavia, stu risicu pò esse ridutta cù l'usu di droghe antivirali o optendu per una C-section in certe situazioni.
Infection with herpes simplex is one of the most common sexually transmitted infections. Because the infection is common in women of reproductive age it can be contracted and transmitted to the fetus during pregnancy and the newborn. Herpes simplex virus is an important cause of neonatal infection, which can lead to death or long-term disabilities. Rarely in the uterus, it occurs frequently during the transmission delivery. The greatest risk of transmission to the fetus and the newborn occurs in case of an initial maternal infection contracted in the second half of pregnancy. The risk of transmission of maternal-fetal-neonatal herpes simplex can be decreased by performing a treatment with antiviral drugs or resorting to a caesarean section in some specific cases.
Infection with herpes simplex is one of the most common sexually transmitted infections. Because the infection is common in women of reproductive age it can be contracted and transmitted to the fetus during pregnancy and the newborn. Herpes simplex virus is an important cause of neonatal infection, which can lead to death or long-term disabilities. Rarely in the uterus, it occurs frequently during the transmission delivery. The greatest risk of transmission to the fetus and the newborn occurs in case of an initial maternal infection contracted in the second half of pregnancy. The risk of transmission of maternal-fetal-neonatal herpes simplex can be decreased by performing a treatment with antiviral drugs or resorting to a caesarean section in some specific cases.
Herpes simplex virus (HSV) tipi 1 è 2 infettate parechje persone in u mondu. Di solitu, u virus ferma tranquillu in e cellule nervose dopu avè infettatu a pelle, ma pò reattivà più tardi, causendu ferite. A volte, porta à prublemi severi cum'è infizzioni oculari, inflammazioni di u cervellu, o cundizioni periculosi in i neonati è in e persone cun sistema immune debule. Mentre i medicini attuali aiutanu à cuntrullà l'infizzioni, u risicu di resistenza à a droga è di l'effetti secundari resta una preoccupazione. Avemu bisognu di novi droghe per indirizzà megliu u virus.
Infection with herpes simplex virus (HSV) types 1 and 2 is ubiquitous in the human population. Most commonly, virus replication is limited to the epithelia and establishes latency in enervating sensory neurons, reactivating periodically to produce localized recurrent lesions. However, these viruses can also cause severe disease such as recurrent keratitis leading potentially to blindness, as well as encephalitis, and systemic disease in neonates and immunocompromised patients. Although antiviral therapy has allowed continual and substantial improvement in the management of both primary and recurrent infections, resistance to currently available drugs and long-term toxicity pose a current and future threat that should be addressed through the development of new antiviral compounds directed against new targets.
Infection with herpes simplex virus (HSV) types 1 and 2 is ubiquitous in the human population. Most commonly, virus replication is limited to the epithelia and establishes latency in enervating sensory neurons, reactivating periodically to produce localized recurrent lesions. However, these viruses can also cause severe disease such as recurrent keratitis leading potentially to blindness, as well as encephalitis, and systemic disease in neonates and immunocompromised patients. Although antiviral therapy has allowed continual and substantial improvement in the management of both primary and recurrent infections, resistance to currently available drugs and long-term toxicity pose a current and future threat that should be addressed through the development of new antiviral compounds directed against new targets.
Ci hè dui tipi di virus herpes simplice (herpes simplex) , tipu 1 (HSV-1) è tipu 2 (HSV-2). HSV-1 più comunemente provoca infezioni in u circondu di a bocca mentre HSV-2 più comunemente provoca infezioni genitali. Sò trasmessi da u cuntattu direttu cù l'individu infettatu. L'herpes genitale hè classificatu cum'è una infezzjoni di trasmissione sessuale. Pò esse sparghje à un zitellu durante u partitu. Dopu l'infezzione, i virus sò trasportati longu i nervi sensitivi à i corpi di e cellule nervose, induve residenu per tutta a vita. I causi di recurrenza ponu include: diminuzione di a funzione immune, stress è esposizione à u sole.
In a maiò parte di i casi, i droghe antivirali sò pigliati solu quandu i sintomi sò severi. A medicazione antivirale di ogni ghjornu pò esse prescritta à qualchissia chì hà infezzione assai frequente. Ùn ci hè micca una vacuna dispunibule è a vacuna di shingles ùn impedisce micca l'herpes simplex. I trattamenti cù medicazione antivirale cum'è aciclovir o valaciclovir ponu diminuite a gravità di i sintomi.
I tassi mundiali di HSV-1 o HSV-2 sò trà 60% è 95% in adulti. HSV-1 hè generalmente infettatu durante a zitiddina. Hè stimatu chì 536 milioni di persone in u mondu (16% di a pupulazione) sò stati infettati da HSV-2 da u 2003 cù tassi più alti trà e donne è quelli in u mondu in via di sviluppu. A maiò parte di e persone cun HSV-2 ùn capiscenu micca chì sò infettati.
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