Porokeratosis - Porokeratosi
☆ AI Dermatology — Free Service
In i risultati Stiftung Warentest 2022 da Germania, a satisfaczione di i cunsumatori cù ModelDerm era solu ligeramente più bassu chè cù cunsultazioni di telemedicina pagate.
In i risultati Stiftung Warentest 2022 da Germania, a satisfaczione di i cunsumatori cù ModelDerm era solu ligeramente più bassu chè cù cunsultazioni di telemedicina pagate.
I bordi duri sporgenti sò caratteristichi.
relevance score : -100.0%
ReferencesPorokeratosis hè una cundizione rara di a pelle caratterizzata da prublemi di cheratinizazione, chì si manifesta cum’è macchie rialzate, in forma di anelli o protuberanze rugose nantu à a pelle. A so caratteristica definitoria sottu u microscopiu hè a presenza di una lamella cornoide, un arrangiu specificu di cellule in a capa superiore di l’epidermide. Porokeratosis si presenta in diverse forme (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis). Hè impurtante nutà chì a porokeratosis pò evolvere in cancro di a pelle. U metudu più affidabile per diagnosticà a porokeratosis hè una biopsia della lesione, ancu s’ellu ùn esiste attualmente un protocolu di trattamentu standard.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) hè una malatia di keratinizazione disordinata. Hè unu di i sei tipi di porokeratosi, è tipicamente affetta spazii più grandi cumparatu cù l'altri (linear, Mibelli's, punctate, palmoplantar disseminated, superficial porokeratosis). U tipu erutivu di porokeratosi spessu si liga à u cancru, à l'immunità debilitata o à l'infiammazione. I fattori di risicu includenu a genetica, a suppressione immune è l'esposizione à u sole. DSAP principia cù bumps rosa o marroni cù bordi rialzati in e zone esposte à u sole, à volte pruvucendu una ligera pruritu. I trattamenti varianu è ponu includere creme topiche, terapia di luce, o medicazione cum'è 5-fluorouracil o retinoids. Ste lesioni sò cunsiderate precancere, cù un 7,5‑10 % di probabilità di trasfurmassi in carcinomu squamusu o basocellulare.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Un omu di 52 anni, prima sanu, hè ghjuntu cù una pezza piatta in forma d'anellu à a fine di u quartu di u pede, chì era quì da 2 anni senza pruvucà sintomi. Accuminciò cum'è una piccula protuberanza dura è hè cresciuta cù u tempu. Malgradu avè pruvatu diversi trattamenti cum'è crioterapia, creme, antifungali è antibiotici, a lesione ùn hè micca megliu. Esaminandula strettamente cù una dermocopia hà dimustratu un centru seccu è rossu cù una fruntiera grossa è rugosa. Un picculu pezzu di pelle prelevatu da u bordu di a lesione mostrava una crescita di cellule anormali in a capa esterna di a pelle, cunfirmendu un diagnosticu di porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
Spessu si realizza una biopsia perchè a lesione pò esse simile à a keratosis actinica o à u carcinoma squamous cell.