Più infurmazione ― Corsu

Porokeratosis hè una cundizione rara di a pelle carattarizata da prublemi di keratinizazione, chì si traduce in macchie rialzate, in forma di anelli o protuberazioni rugose nantu à a pelle. A so caratteristica di definizione sottu u microscopiu hè a prisenza di lamella cornoide, un arrangementu specificu di cellule in a capa superiore di a pelle. Porokeratosis vene in diverse forme (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis) . Hè impurtante di nutà chì porokeratosis pò esse sviluppatu in cancru di a pelle. U megliu modu per diagnosticà porokeratosis hè per via di una biòpsia di u cunfini elevatu, ancu s'ellu ùn ci hè attualmente un protocolu di trattamentu standard.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.

Disseminated superficial actinic porokeratosis (DSAP) hè una malatia di keratinizazione disordinata. Hè unu di i sei tipi di porokeratosis, è tipicamente affetta spazii più grandi cumparatu cù l'altri (linear, Mibelli's, punctate, palmoplantar disseminated, superficial porokeratosis) . U tipu erutivu di porokeratosis spessu liga à u cancru, l'immunità debilitatu o inflammazioni. I fattori di risicu implicanu a genetica, a suppressione immune è l'esposizione à u sole. DSAP principia cum'è bumps rosa o marroni cù bordi rialzati in i zoni esposti à u sole, à volte pruvucannu una ligera prurito. I trattamenti varienu è ponu include creme topiche, terapia di luce, o medicazione cum'è 5-fluorouracil o retinoids. Ces lésions sont considérées comme précancéreuses, avec un 7. 5 - 10 % de chances de se transformer en carcinome squameux ou basocellulaire.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.

Un omu di 52 anni, prima sanu, hè ghjuntu cù una pezza piatta in forma di anellu à a fine di u quartu toe, chì era quì da 2 anni senza pruvucà sintomi. Accuminciau cum'è una piccula bump dura è hè cresciutu fora cù u tempu. Malgradu à pruvà diversi trattamenti cum'è crioterapia, creme, antifungali è antibiotici, u patch ùn hè micca megliu. Esaminendula strettamente cù una dermocopsia hà dimustratu un centru seccu è rossu cù una fruntiera grossa è rugosa. Un picculu pezzu di pelle pigliata da u bordu di u patch mostrava una crescita di cellule anormali in a capa esterna di a pelle, cunfirmendu un diagnosticu di porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.