Più infurmazione ― Corsu

Porokeratosis hè una cundizione rara di a pelle carattarizata da prublemi di keratinizazione, chì si traduce in macchie rialzate, in forma di anelli o protuberazioni rugose nantu à a pelle. A so caratteristica di definizione sottu u microscopiu hè a prisenza di lamella cornoide, un arrangementu specificu di cellule in a capa superiore di a pelle. Porokeratosis vene in diverse forme (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis). Hè impurtante di nutà chì porokeratosis pò esse sviluppatu in cancru di a pelle. U megliu modu per diagnosticà porokeratosis hè per via di una biòpsia di u cunfini elevatu, ancu s'ellu ùn ci hè attualmente un protocolu di trattamentu standard.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.

Disseminated superficial actinic porokeratosis (DSAP) hè una malatia di keratinizazione disordinata. Hè unu di i sei tipi di porokeratosis, è tipicamente affetta spazii più grandi cumparatu cù l'altri (linear, Mibelli, punctate, palmoplantar disseminated, superficial porokeratosis). U tipu erutivu di porokeratosis spessu liga à u cancru, l'immunità debilitata o inflammazioni. I fattori di risicu implicanu a genetica, l'immunosuppressione è l'esposizione à u sole. DSAP principia cum'è protuberanze (bumps) rosa o marroni cù bordi rialzati in i zoni esposti à u sole, à volte pruvucendu una ligera pruritu. I trattamenti varienu è ponu include creme topiche, terapia di luce, o medicazione cum'è 5-fluorouracil o retinoidi (retinoids). Ces lésions sont considérées comme précancéreuses, avec un 7.5‑10 % de chances de se transformer en carcinoma squamose (squamous cell carcinoma) ou carcinoma basocellulare (basal cell carcinoma).
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.

Un omu di 52 anni, prima sanu, hè ghjuntu cù una pezza piatta in forma di anellu à a fine di u quartu toe, chì era quì da 2 anni senza pruvucà sintomi. Accuminciò cum’è una piccula keratotic papule è gradualmente enlarged centrifugally. Malgradu à pruvà diversi trattamenti cum’è cryotherapy, topical corticosteroids, antifungals è antibiotics, u lesion ùn hè micca megliu. Esaminandula strettamente cù una dermoscopic examination hà dimustratu un scaly atrophic erythematous central area è una sharply demarcated peripheral hyperkeratotic structure. Un skin biopsy di u bordu di u lesion mostrava una cornoid lamella cù una column of parakeratotic cells extending from an epidermal invagination with loss of the granular layer. A clinicopathologic correlation era consistente cù porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.