Syphilis - Sifilide
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Chancres ― infezione sifilitica primaria da Treponema pallidum
References
A sifilide hè una malatia di trasmissione sessuale causata da u bacteriu Treponema pallidum. In questu studiu, ci focalizemu nantu à 57 pazienti di età 18-68 cù sifilis secundaria.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
La sifilide è una infezione batterica causata da Treponema pallidum. Pò imite diverse malatie, guadagnendu u soprannomu great imitator. A sifilide afecta ancu milioni in u mondu, ma pò esse trattata in modu efficace cù penicillina.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Treponema pallidum provoca a sifilis per u cuntattu sessuale o da a mamma à u zitellu durante a gravidanza. Ancu s'ellu ci sò teste simplici per diagnostichi è u trattamentu cù un colpu di penicillina à longa durata funziona bè, a sifilis hè diventata un grande prublema in u mondu sanu. Questu hè soprattuttu veru trà l'omi chì anu sessu cù l'omi (MSM) in i paesi cù ingressu altu è mediu. Mentre chì certi paesi à pocu redditu anu riunitu i scopi di l'OMS per impedisce a sifilis di passà da a mamma à u zitellu, ci hè un aumentu preoccupante di a sifilis trà i MSM HIV-positivi.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
(1) Fegato allargatu: Questu hè spessu truvatu è pò accade à fiancu à una spleen allargata. Esaminà una biòpsia di fegato sottu microscopia di campu scuru pò revelà a presenza di a spirocheta. I testi di a funzione di u fegatu ponu mostra anormalità. (2) Yellowing of the Skin (Ictericia) : Se qualchissia mostra ictericia dipende da quantu hè affettatu u fegatu. (3) Runny Nose: Spessu unu di i primi signali, generalmente in a prima settimana dopu a nascita. (4) Noduli linfatichi gonfiati: Inflazione generalizata di i nodi linfatici, di solitu indolore, hè ancu cumuni. (5) Rash di a pelle: Un rash tipicamenti appare una à duie settimane dopu à u nasu runny. Puderete vede picculi spots rossi o rosati nantu à u spinu, i glutei, i cosci è i soli di i pedi. Questa rash pò avanzà à scorcia è crosta.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
○ Diagnosi è Trattamentu
VDRL è RPR ponu esse utilizati per cunfirmà l'infezzione recente è u screen per a sifilis. A prova FTA-ABS hè una prova più specifica è pò esse usata per verificà a storia di infezzione precedente. A penicillina hè usata per trattà a sifilis.