Acute generalized exanthematous pustulosis - Pwstwlosis Exanthematous Cyffredinol Acíwt
Mae Pwstwlosis Exanthematous Cyffredinol Acíwt (Acute generalized exanthematous pustulosis) (AGEP) yn adwaith croen prin sydd mewn 90% o achosion yn gysylltiedig â rhoi meddyginiaeth. Nodweddir pwstwlosis exanthematous cyffredinol acíwt (acute generalized exanthematous pustulosis) gan echdoriadau sydyn ar y croen sy'n ymddangos bum niwrnod ar gyfartaledd ar ôl i feddyginiaeth ddechrau. Mae’r ffrwydradau hyn yn llinorod, h.y. ffrwydriad bach coch gwyn neu goch ar y croen sy’n cynnwys defnydd cymylog neu buraidd (crawn). Mae'r briwiau croen fel arfer yn gwella o fewn 1-3 diwrnod o atal y feddyginiaeth droseddol.
☆ Yng nghanlyniadau Stiftung Warentest 2022 o’r Almaen, roedd boddhad defnyddwyr â ModelDerm ond ychydig yn is nag ymgynghoriadau telefeddygaeth taledig.
Mae briwiau eang gydag erythema a llinorod yn ymddangos yn sydyn.
References
Mae Acute generalized exanthematous pustulosis (AGEP) yn adwaith croen sydd wedi'i farcio gan bumps bach llawn crawn ar waelod croen coch. Mae fel arfer yn digwydd pan fydd rhywun yn cymryd rhai meddyginiaethau, fel gwrthfiotigau, ac yn lledaenu'n gyflym ar draws y corff. Ar ôl atal y feddyginiaeth sbarduno, mae'r symptomau fel arfer yn diflannu o fewn pythefnos, gan adael rhywfaint o golli croen yn aml. Er nad ydynt fel arfer yn ddifrifol ac yn gyfyngedig i'r croen, gellir dosbarthu achosion difrifol ochr yn ochr ag adweithiau croen difrifol eraill fel Stevens-Johnson syndrome neu toxic epidermal necrolysis. Gofal cefnogol yn bennaf yw triniaeth, ac mae'r prognosis ar gyfer datrysiad cyflawn o'r afiechyd fel arfer yn rhagorol.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
Daeth dyn 76 oed i’r ystafell argyfwng oherwydd bod ei groen wedi newid dros y ddau ddiwrnod diwethaf. Daeth meddygon o hyd i glytiau coch a mannau uchel ar ei foncyff a'i freichiau a'i goesau. Wrth i amser fynd yn ei flaen, ymunodd y clytiau hyn â'i gilydd, a datblygodd bumps tebyg i pimple yn yr ardaloedd coch. Dangosodd profion gyfrif celloedd gwaed gwyn uchel gyda llawer o fath o'r enw neutrophils, a lefelau uwch o C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
