Mwy o wybodaeth ― Cymraeg

Daeth dynes 26 oed i’n clinig yn cwyno am frech goslyd ar ei choesau yr oedd wedi’i chael ers 10 mlynedd. Er gwaethaf defnyddio hufenau steroid a hufen tazaroten, ni wellodd y frech. Nid oedd ganddi unrhyw hanes teuluol perthnasol. Pan wnaethom ei harchwilio, daethom o hyd i glytiau garw, wedi'u codi ar flaen ei choesau, a oedd yn cyfateb i glefyd o'r enw lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.

Mae Lichen Amyloidosis yn gyflwr croen prin sy'n gysylltiedig â chosi parhaus o achos anhysbys. Yn nodweddiadol mae'n ymddangos fel clystyrau o glytiau uwch, afliwiedig ar arwynebau allanol y croen. Mae Lichen Amyloidosis fel arfer yn ymddangos mewn pobl rhwng 50 a 60 oed ac yn anffodus, does dim gwellhad iddo. Nid yw triniaethau sydd ar gael nawr yn gweithio'n dda fel arfer.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.

Mae Lichen amyloidosis yn gyflwr croen cosi hir-barhaol. Mae'n adnabyddus am glystyrau o lympiau trwchus a geir yn bennaf ar y cefn, yr shins, y cluniau a'r breichiau. Pan gaiff ei archwilio o dan ficrosgop, mae Lichen amyloidosis yn dangos crynhoad o amyloid yn haen uchaf y croen ynghyd â thewychu ac ehangu haen allanol y croen. Er nad yw union achos Lichen amyloidosis wedi'i ddeall yn llawn eto, mae astudiaethau blaenorol wedi'i gysylltu â ffactorau fel rhwbio neu ffrithiant ar y croen, marwolaeth celloedd, heintiau firaol, ymhlith eraill. Mae'n ymddangos bod Lichen amyloidosis yn gysylltiedig â sawl cyflwr croen arall (atopic dermatitis, lichen planus, mycosis fungoides) .
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.