Dysplastic nevus - Nevus Dysplastig
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Dysplastic nevi ― Argymhellir biopsi i Orllewinwyr.
References
Mae Dysplastic nevus , a elwir hefyd yn nevus annodweddiadol neu Clarks, wedi sbarduno dadleuon mewn dermatoleg a dermatopatholeg. Mae meddygon yn aml yn biopsi'r tyrchod daear hyn oherwydd gallant edrych yn annormal a chodi pryderon am felanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
Gall Dysplastic nevi , a elwir hefyd yn annodweddiadol neu Clark nevi, arwain at felanoma weithiau. Mae tua 36% o felanomas i'w cael ger nevi dysplastig. Mae arwyddion y gall nevus dysplastig droi'n felanoma yn cynnwys siâp anwastad, mwy o newidiadau pigment, neu liw llwydaidd. Mae'r canserau hyn fel arfer yn digwydd yn iau (tua chanol y tridegau) , gallant fod yn lluosog, ac maent yn aml ar y boncyff. Yn enetig, mae dysplastic nevi rhwng nevi anfalaen a melanoma. Fodd bynnag, dim ond 20% i 30% o felanomas sy'n dod o nevi sy'n bodoli. Gan nad yw'r rhan fwyaf o nevi yn troi'n felanoma, nid yw'n cael ei argymell fel arfer i gael gwared arnynt yn ataliol.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Mae melanoma yn fath o diwmor sy'n ffurfio pan fydd melanocytes, celloedd sy'n gyfrifol am liw croen, yn dod yn ganseraidd. Mae melanocytes yn tarddu o'r arfbais niwral. Mae hyn yn golygu y gall melanomas ddatblygu nid yn unig ar y croen ond hefyd mewn meysydd eraill lle mae celloedd crib niwral yn mudo, fel y llwybr gastroberfeddol a'r ymennydd. Mae’r gyfradd oroesi ar gyfer cleifion â melanoma cyfnod cynnar (cam 0) yn uchel, sef 97%, ac mae’n gostwng yn sylweddol i tua 10% ar gyfer y rhai sy’n cael diagnosis o glefyd cam datblygedig (cam IV) .
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
○ canser risk
Fel y gwelir mewn unigolion Caucasian yn yr Unol Daleithiau, mae gan y rhai â nevi dysplastig risg oes o ddatblygu melanoma o fwy na 10%. Ar y llaw arall, mae gan y rhai heb unrhyw nevus dysplastig risg o ddatblygu melanoma o lai nag 1%.
○ Rhagofal i unigolion â dysplastic nevi
Mae hunan-archwiliad croen fel arfer yn cael ei argymell ar gyfer atal melanoma (trwy nodi nevi annodweddiadol y gellir ei dynnu) neu ar gyfer canfod tiwmorau presennol yn gynnar. Dylai pobl sydd â hanes personol neu deuluol o ganser y croen neu o nevi annodweddiadol lluosog weld dermatolegydd o leiaf unwaith y flwyddyn i sicrhau nad ydynt yn datblygu melanoma.
Mae'r talfyriad [ABCDE] wedi bod yn ddefnyddiol ar gyfer helpu darparwyr gofal iechyd a lleygwyr i gofio nodweddion allweddol melanoma. Yn anffodus i'r person cyffredin, efallai y bydd gan lawer o keratoses seborrheic, rhai lentigo senilis, a hyd yn oed dafadennau nodweddion [ABCDE], ac ni ellir eu gwahaniaethu oddi wrth felanoma.
○ [ABCDE]
Asymmetrical: briwiau croen anghymesur.
Border: Mae ffin y briw yn afreolaidd.
Color: fel arfer mae gan felanomas sawl lliw afreolaidd.
Diameter: mae nevi sy'n fwy na 6 mm yn fwy tebygol o fod yn felanomas na nevi llai.
Evolution: Gall esblygiad (h.y. newid) nevus neu anaf ddangos bod y briw yn dod yn falaen.