Keloid
☆ AI Dermatology — Free Service
Yng nghanlyniadau Stiftung Warentest 2022 o’r Almaen, roedd boddhad defnyddwyr â ModelDerm ond ychydig yn is nag ymgynghoriadau telefeddygaeth taledig.
Yng nghanlyniadau Stiftung Warentest 2022 o’r Almaen, roedd boddhad defnyddwyr â ModelDerm ond ychydig yn is nag ymgynghoriadau telefeddygaeth taledig.
Keloid ar ôl llawdriniaeth ar y breichyn a gafodd ei drin â chwistrelliad triamcinolone mewn‑yn‑lleoliad. Yr ardal erythema wedi’i swyno ar yr ochr chwith yw’r ardal sydd wedi’i thrin.
Keloid cefn‑auric (Posterior auricular Keloid)
Gall keloidau ar gwddau'r traed fod yn anghyfforddus i gerdded ymlaen. Mae pigiadau steroid mewn-anadlol yn cael eu perfformio sawl gwaith fel arfer.
Gwelir keloidau yn gyffredin ar y breichiau uchaf.
Amlygiad nodweddiadol o keloidau'r frest.
relevance score : -100.0%
ReferencesMae keloidau yn ffurfio oherwydd iachâd anarferol ar ôl anaf i'r croen neu lid. Mae ffactorau genetig ac amgylcheddol yn cyfrannu at eu datblygiad, gyda chyfraddau uwch mewn unigolion â chroen dywyllach o dras Affricanaidd, Asiaidd a Sbaenaidd. Mae keloidau yn digwydd pan fydd ffibroblastau'n gorfywiog, gan gynhyrchu colagen gormodol a ffactorau twf. Mae hyn yn arwain at ffurfio bwndeli colagen mawr, annormal a elwir yn colagen keloidal (keloidal collagen), ynghyd â chynnydd mewn ffibroblastau. Yn glinigol, mae keloidau yn ymddangos fel nodwlau rubber (rubbery nodules) cadarn mewn ardaloedd a anafwyd yn flaenorol. Yn wahanol i greithiau hipertrophig (hypertrophic scars), mae keloidau yn ymestyn y tu hwnt i'r safle trawma gwreiddiol. Gall cleifion brofi poen, cosi neu losgi. Mae triniaethau amrywiol ar gael, gan gynnwys pigiadau steroid, cryotherapy, radiotherapy, a laser therapy.
Keloids result from abnormal wound healing in response to skin trauma or inflammation. Keloid development rests on genetic and environmental factors. Higher incidences are seen in darker skinned individuals of African, Asian, and Hispanic descent. Overactive fibroblasts producing high amounts of collagen and growth factors are implicated in the pathogenesis of keloids. As a result, classic histologic findings demonstrate large, abnormal, hyalinized bundles of collagen referred to as keloidal collagen and numerous fibroblasts. Keloids present clinically as firm, rubbery nodules in an area of prior injury to the skin. In contrast to normal or hypertrophic scars, keloidal tissue extends beyond the initial site of trauma. Patients may complain of pain, itching, or burning. Multiple treatment modalities exist although none are uniformly successful. The most common treatments include intralesional or topical steroids, cryotherapy, surgical excision, radiotherapy, and laser therapy.
Keloids result from abnormal wound healing in response to skin trauma or inflammation. Keloid development rests on genetic and environmental factors. Higher incidences are seen in darker skinned individuals of African, Asian, and Hispanic descent. Overactive fibroblasts producing high amounts of collagen and growth factors are implicated in the pathogenesis of keloids. As a result, classic histologic findings demonstrate large, abnormal, hyalinized bundles of collagen referred to as keloidal collagen and numerous fibroblasts. Keloids present clinically as firm, rubbery nodules in an area of prior injury to the skin. In contrast to normal or hypertrophic scars, keloidal tissue extends beyond the initial site of trauma. Patients may complain of pain, itching, or burning. Multiple treatment modalities exist although none are uniformly successful. The most common treatments include intralesional or topical steroids, cryotherapy, surgical excision, radiotherapy, and laser therapy.
Mae'r ymchwil presennol yn awgrymu mai silicone gel neu gynfasau ynghyd â phigiadau corticosteroid yw'r driniaeth gychwynnol a ffefrir ar gyfer keloidau. Gellir hefyd ystyried triniaethau ychwanegol fel 5-fluorouracil intralesional (5-FU), bleomycin, neu verapamil, er bod eu heffeithiolrwydd yn amrywio. Gall therapi laser, o'i gyfuno â phigiadau corticosteroid neu steroidau argroenol dan gyfyngiad, wella treiddiad cyffuriau. Ar gyfer keloidau, dangoswyd bod tynnu llawfeddygol ac yna therapi ymbelydredd ar unwaith yn effeithiol. Yn olaf, profwyd bod defnyddio gorchuddion silicone a therapi pwysau yn lleihau'r tebygolrwydd y bydd keloidau yn digwydd eto.
Current literature supports silicone gel or sheeting with corticosteroid injections as first-line therapy for keloids. Adjuvant intralesional 5-fluorouracil (5-FU), bleomycin, or verapamil can be considered, although mixed results have been reported with each. Laser therapy can be used in combination with intralesional corticosteroids or topical steroids with occlusion to improve drug penetration. Excision of keloids with immediate post-excision radiation therapy is an effective option for recalcitrant lesions. Finally, silicone sheeting and pressure therapy have evidence for reducing keloid recurrence.
Current literature supports silicone gel or sheeting with corticosteroid injections as first-line therapy for keloids. Adjuvant intralesional 5-fluorouracil (5-FU), bleomycin, or verapamil can be considered, although mixed results have been reported with each. Laser therapy can be used in combination with intralesional corticosteroids or topical steroids with occlusion to improve drug penetration. Excision of keloids with immediate post-excision radiation therapy is an effective option for recalcitrant lesions. Finally, silicone sheeting and pressure therapy have evidence for reducing keloid recurrence.
Ar hyn o bryd, nid oes un driniaeth sy'n addas i bawb sy'n gwarantu cyfradd ailadrodd gyson isel ar gyfer keloidau. Fodd bynnag, mae'r opsiynau cynyddol, fel defnyddio laserau ochr yn ochr â steroidau neu gyfuno 5-fluorouracil â steroidau, yn profi'n addawol. Gallai ymchwil yn y dyfodol ganolbwyntio ar ba mor dda y mae triniaethau newydd, fel impio braster awtologaidd neu therapïau bôn-gelloedd, yn gweithio ar gyfer rheoli keloidau.
There continues to be no gold standard of treatment that provides a consistently low recurrence rate; however the increasing number of available treatments and synergistic combinations of these treatments (i.e., laser-based devices in combination with intralesional steroids, or 5-fluorouracil in combination with steroid therapy) is showing favorable results. Future studies could target the efficacy of novel treatment modalities (i.e., autologous fat grafting or stem cell-based therapies) for keloid management.
There continues to be no gold standard of treatment that provides a consistently low recurrence rate; however the increasing number of available treatments and synergistic combinations of these treatments (i.e., laser-based devices in combination with intralesional steroids, or 5-fluorouracil in combination with steroid therapy) is showing favorable results. Future studies could target the efficacy of novel treatment modalities (i.e., autologous fat grafting or stem cell-based therapies) for keloid management.
Mae keloidau yn ganlyniad i ormod o weithgynhyrchu tisg (colagen math 3) ar le'r anafiad wedi'i wella. Mae keloidau’n galed, elastig neu’n nodwlau gwydr, a gallant amrywio o liw pinc i liw'r croen, neu o goch i frown tywyll. Nid yw'r cicrwm keloid yn haintus, ond gall fod yn gysylltiedig â chwydu difrifol, poen fel pin, a newidiadau mewn gwead. Mewn achosion difrifol, gall effeithio ar symudiad y croen. Mae keloidau’n wahanol i glociau hypertrophig, sy'n glociau codi nad ydynt yn tyfu y tu hwnt i derfynau'r waliau gwreiddiol.
Scars are a natural and normal part of healing following an injury to the integumentary system. Ideally, scars should be flat, narrow, and color-matched. Several factors can contribute to poor wound healing. These include but are not limited to infection, poor blood flow, ischemia, and trauma. Proliferative, hyperpigmented, or contracted scars can cause serious problems with both function and emotional well-being.
Scars are a natural and normal part of healing following an injury to the integumentary system. Ideally, scars should be flat, narrow, and color-matched. Several factors can contribute to poor wound healing. These include but are not limited to infection, poor blood flow, ischemia, and trauma. Proliferative, hyperpigmented, or contracted scars can cause serious problems with both function and emotional well-being.
Gwelir creithiau keloid yn amlach mewn pobl o dras Affricanaidd, Asiaidd neu Hispaniaidd. Mae gan bobl rhwng 10 a 30 oed dueddiad uwch i ddatblygu keloid na'r henoed.
Er eu bod fel arfer yn digwydd ar safle anaf, gall keloid godi'n ddigymell hefyd. Gallant ddigwydd ar safle tyllu a hyd yn oed o rywbeth mor syml â pimpel (pimple) neu grafiad. Gallant ddigwydd o ganlyniad i acne difrifol neu greithiau brech yr wyaden (chickenpox), haint ar safle clwyf, trawma ailadroddol i ardal, tensiwn croen gormodol yn ystod cau clwyf, neu gorff estron mewn clwyf.
Gall creithiau keloid ddatblygu ar ôl llawdriniaeth. Maent yn fwy cyffredin mewn rhai safleoedd, megis y brest ganolog (after sternotomy), y cefn a'r ysgwyddau (sy'n deillio o acne fel arfer), a llabedau'r clust (ear lobes). Gallant hefyd ddigwydd ar dyllu'r corff. Y mannau mwyaf cyffredin yw llabedau'r clust, breichiau, rhanbarth y pelfis, a thros asgwrn y goler.
Y triniaethau sydd ar gael yw therapi pwysau, gorchuddion gel silicon, triamcinolone acetonide mewn-anafol, cryolawdriniaeth, ymbelydredd, therapi laser, Interferon, 5‑FU a thorri llawfeddygol.
○ triniaeth
Gall creithiau hypertrophic (hypertrophic scars) wella gyda 5 i 10 pigiad steroid mewn-anafol bob 1 mis.
#Triamcinolone intralesional injection
Gellir rhoi cynnig ar driniaeth laser ar gyfer erythema sy'n gysylltiedig â creithiau, ond gall pigiadau triamcinolone hefyd wella'r erythema trwy fflatio'r graith.
#Dye laser (e.g. V-beam)